{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:47:00Z","timestamp":1788871620842,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":2878,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000328","name":"Leukaemia Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1086\/444472","type":"journal-article","created":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T10:37:33Z","timestamp":1123151853000},"page":"420-429","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["A High-Density SNP Genomewide Linkage Scan for Chronic Lymphocytic Leukemia\u2013Susceptibility Loci"],"prefix":"10.1016","volume":"77","author":[{"given":"Gabrielle S.","family":"Sellick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Allinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estella","family":"Matutes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.S.","family":"Dyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viggo","family":"J\u00f8nsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton W.","family":"Langerak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca R.","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Wiley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lyttelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Callea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Yuille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Catovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Houlston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/444472_bib5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng786","article-title":"Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees","volume":"30","author":"Abecasis","year":"2002","journal-title":"Nat Genet"},{"key":"10.1086\/444472_bib6","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/sj.leu.2401531","article-title":"Linkage analysis for ATM in familial B cell chronic lymphocytic leukaemia","volume":"13","author":"Bevan","year":"1999","journal-title":"Leukemia"},{"key":"10.1086\/444472_bib7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/bjc.1987.158","article-title":"Chronic lymphocytic leukaemia: case-control epidemiological study in Yorkshire","volume":"56","author":"Cartwright","year":"1987","journal-title":"Brit J Cancer"},{"key":"10.1086\/444472_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/geno.1995.9003","article-title":"A comparison of linkage disequilibrium measure for fine-scale mapping","volume":"29","author":"Devlin","year":"1995","journal-title":"Genomics"},{"key":"10.1086\/444472_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1086\/424696","article-title":"Guidelines for genotyping in genomewide linkage studies: single-nucleotide-polymorphism maps versus microsatellite maps","volume":"75","author":"Evans","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1086\/444472_bib10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/gepi.1370100108","article-title":"Distribution of the admixture test for the detection of linkage under heterogeneity","volume":"10","author":"Faraway","year":"1993","journal-title":"Genet Epidemiol"},{"key":"10.1086\/444472_bib11","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1046\/j.1365-2141.2003.04372.x","article-title":"A genome scan of 18 families with chronic lymphocytic leukaemia","volume":"121","author":"Goldin","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1086\/444472_bib12","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1182\/blood-2004-01-0341","article-title":"Familial risk of lymphoproliferative tumors in families of patients with chronic lymphocytic leukemia: results from the Swedish family-cancer database","volume":"104","author":"Goldin","year":"2004","journal-title":"Blood"},{"key":"10.1086\/444472_bib13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/10245330400010661","article-title":"Molecular cytogenetic analysis of B-CLL patients with aggressive disease","volume":"9","author":"Gozzetti","year":"2004","journal-title":"Hematology"},{"key":"10.1086\/444472_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/75514","article-title":"Allegro, a new computer program for multipoint linkage analysis","volume":"25","author":"Gudbjartsson","year":"2000","journal-title":"Nat Genet"},{"key":"10.1086\/444472_bib15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1600-0609.1975.tb01063.x","article-title":"Familial leukaemia: a study of 909 families","volume":"15","author":"Gunz","year":"1975","journal-title":"Scand J Haematol"},{"key":"10.1086\/444472_bib16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/genetics\/117.2.331","article-title":"Gametic disequilibrium measures: proceed with caution","volume":"117","author":"Hedrick","year":"1987","journal-title":"Genetics"},{"key":"10.1086\/444472_bib17","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0145-2126(03)00023-7","article-title":"Causation of chronic lymphocytic leukemia\u2014insights from familial disease","volume":"27","author":"Houlston","year":"2003","journal-title":"Leuk Res"},{"key":"10.1086\/444472_bib18","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1086\/426000","article-title":"Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis","volume":"75","author":"Huang","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1086\/444472_bib19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1086\/422195","article-title":"Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites","volume":"75","author":"John","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1086\/444472_bib20","first-page":"5","article-title":"Cytogenetic abnormalities in chronic lymphocytic leukemia","volume":"42","author":"Karnolsky","year":"2000","journal-title":"Folia Med (Plovdiv)"},{"key":"10.1086\/444472_bib21","first-page":"497","article-title":"Localization of predisposition to Hodgkin disease in the HLA class II region","volume":"54","author":"Klitz","year":"1994","journal-title":"Am J Hum Genet"},{"key":"10.1086\/444472_bib22","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: a unified multipoint approach","volume":"58","author":"Kruglyak","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1086\/444472_bib23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng1195-241","article-title":"Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results","volume":"11","author":"Lander","year":"1995","journal-title":"Nat Genet"},{"key":"10.1086\/444472_bib24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1093\/oxfordjournals.aje.a115387","article-title":"Familial cancer history and chronic lymphocytic leukaemia: a case-control study","volume":"130","author":"Linet","year":"1989","journal-title":"Am J Epidemiol"},{"key":"10.1086\/444472_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/1097-0215(200102)9999:9999<::AID-IJC1167>3.0.CO;2-A","article-title":"Association of chronic lymphocytic leukaemia with specific alleles of the HLA-DR4:DR53:DQ8 haplotype in German patients","volume":"92","author":"Machulla","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1086\/444472_bib26","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1101\/gr.2014904","article-title":"Parallel genotyping of over 10,000 SNPs using a one-primer assay on a high-density oligonucleotide array","volume":"14","author":"Matsuzaki","year":"2004","journal-title":"Genome Res"},{"key":"10.1086\/444472_bib27","series-title":"World Health Organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues","first-page":"127","article-title":"Chronic lymphocytic leukaemia\/small lymphocytic lymphoma","author":"M\u00fcller-Hermelink","year":"2001"},{"key":"10.1086\/444472_bib28","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0145-2126(91)90005-E","article-title":"Familial cancers associated with subtypes of leukaemia and non-Hodgkin\u2019s lymphoma","volume":"15","author":"Pottern","year":"1991","journal-title":"Leuk Res"},{"key":"10.1086\/444472_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF01730372","article-title":"Cancer mortality of family members of patients with chronic lymphocytic leukaemia","volume":"10","author":"Radovanovic","year":"1994","journal-title":"Eur J Epidemiol"},{"key":"10.1086\/444472_bib30","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1182\/blood.V100.2.635","article-title":"Monoclonal B lymphocytes with the characteristics of \u201cindolent\u201d chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts","volume":"100","author":"Rawstron","year":"2002","journal-title":"Blood"},{"key":"10.1086\/444472_bib31","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1182\/blood-2002-03-0892","article-title":"Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion","volume":"100","author":"Rawstron","year":"2002","journal-title":"Blood"},{"key":"10.1086\/444472_bib32","series-title":"SEER Cancer Statistics Review 1975-2000","year":"2003"},{"key":"10.1086\/444472_bib33","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1086\/425870","article-title":"Comparison of microsatellites versus single-nucleotide polymorphisms in a genome linkage screen for prostate cancer-susceptibility loci","volume":"75","author":"Schaid","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1086\/444472_bib34","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1600-0609.1973.tb00102.x","article-title":"Chronic lymphocytic leukaemia in 5 siblings","volume":"11","author":"Schweitzer","year":"1973","journal-title":"Scand J Haemat"},{"key":"10.1086\/444472_bib35","series-title":"The effective management of chronic lymphocytic leukaemia","first-page":"3","article-title":"Familial chronic lymphocytic leukaemia","author":"Sellick","year":"2004"},{"key":"10.1086\/444472_bib36","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gnh163","article-title":"Genomewide linkage searches for Mendelian disease loci can be efficiently conducted using high-density SNP genotyping arrays","volume":"32","author":"Sellick","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1086\/444472_bib37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0140-6736(98)10117-4","article-title":"Inactivation of ataxia telangectasia mutated gene in B-cell chronic lymphocytic leukaemia","volume":"353","author":"Stankovic","year":"1999","journal-title":"Lancet"},{"key":"10.1086\/444472_bib38","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1056\/NEJM198705213162101","article-title":"Breast and other cancers in families with ataxia-telangiectasia","volume":"316","author":"Swift","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1086\/444472_bib39","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1093\/bioinformatics\/bti449","article-title":"SNPLINK: multipoint linkage analysis of densely distributed SNP data incorporating automated linkage disequilibrium removal","volume":"21","author":"Webb","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1086\/444472_bib40","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2307\/2533202","article-title":"A class of tests for linkage using affected pedigree members","volume":"50","author":"Whittemore","year":"1994","journal-title":"Biometrics"},{"key":"10.1086\/444472_bib41","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1182\/blood.V100.2.603","article-title":"ATM mutations are rare in familial chronic lympohcytic leukaemia","volume":"100","author":"Yuille","year":"2002","journal-title":"Blood"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707630225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707630225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:14:26Z","timestamp":1762078466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707630225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0002929707630225"],"URL":"https:\/\/doi.org\/10.1086\/444472","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A High-Density SNP Genomewide Linkage Scan for Chronic Lymphocytic Leukemia\u2013Susceptibility Loci","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Human Genetics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1086\/444472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}