{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:33:06Z","timestamp":1791109986937,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":2848,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1086\/491749","type":"journal-article","created":{"date-parts":[[2005,9,8]],"date-time":"2005-09-08T15:50:36Z","timestamp":1126194636000},"page":"643-652","source":"Crossref","is-referenced-by-count":42,"title":["Linkage and Association Studies Identify a Novel Locus for Alzheimer Disease at 7q36 in a Dutch Population-Based Sample"],"prefix":"10.1016","volume":"77","author":[{"given":"Rosa","family":"Rademakers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Cruts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristel","family":"Sleegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Dermaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Theuns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurii","family":"Aulchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Weckx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"De Pooter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marleen","family":"Van den Broeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Corsmit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"De Rijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Del-Favero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"van Swieten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia M.","family":"van Duijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Van Broeckhoven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/491749_bib12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neulet.2004.12.065","article-title":"An autosomal genomic screen for dementia in an extended Amish family","volume":"379","author":"Ashley-Koch","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1086\/491749_bib13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/nar\/27.2.573","article-title":"Tandem repeats finder: a program to analyze DNA sequences","volume":"27","author":"Benson","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.1086\/491749_bib14","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1086\/491749_bib15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1098-1004(1998)11:3<183::AID-HUMU1>3.0.CO;2-J","article-title":"Presenilin mutations in Alzheimer\u2019s disease","volume":"11","author":"Cruts","year":"1998","journal-title":"Hum Mutat"},{"key":"10.1086\/491749_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/hmg\/7.1.43","article-title":"Estimation of the genetic contribution of presenilin-1 and -2 mutations in a population-based study of presenile Alzheimer disease","volume":"7","author":"Cruts","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1086\/491749_bib17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ana.10507","article-title":"PRNP Val129 homozygosity increases risk for early-onset Alzheimer\u2019s disease","volume":"53","author":"Dermaut","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1086\/491749_bib18","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s004150050603","article-title":"Familial Creutzfeldt-Jakob disease in a patient carrying both a presenilin 1 missense substitution and a prion protein gene insertion","volume":"247","author":"Dermaut","year":"2000","journal-title":"J Neurol"},{"key":"10.1086\/491749_bib19","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1086\/302200","article-title":"The Glu318Gly substitution in presenilin 1 is not causally related to Alzheimer disease","volume":"64","author":"Dermaut","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1086\/491749_bib20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/380152a0","article-title":"A comprehensive genetic map of the human genome based on 5,264 microsatellites","volume":"380","author":"Dib","year":"1996","journal-title":"Nature"},{"key":"10.1086\/491749_bib21","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer\u2019s disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1086\/491749_bib22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nature01782","article-title":"The DNA sequence of human chromosome 7","volume":"424","author":"Hillier","year":"2003","journal-title":"Nature"},{"key":"10.1086\/491749_bib23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/BF00145007","article-title":"Determinants of disease and disability in the elderly: the Rotterdam Elderly Study","volume":"7","author":"Hofman","year":"1991","journal-title":"Eur J Epidemiol"},{"key":"10.1086\/491749_bib24","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1212\/WNL.39.12.1589","article-title":"History of dementia and Parkinson\u2019s disease in 1st-degree relatives of patients with Alzheimer\u2019s disease","volume":"39","author":"Hofman","year":"1989","journal-title":"Neurology"},{"key":"10.1086\/491749_bib25","first-page":"171","article-title":"Natural history of Alzheimer\u2019s disease","volume":"13","author":"Honig","year":"2001","journal-title":"Aging (Milano)"},{"key":"10.1086\/491749_bib26","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1093\/brain\/awh501","article-title":"A multigenerational pedigree of late-onset Alzheimer\u2019s disease implies new genetic causes","volume":"128","author":"Jimenez-Escrig","year":"2005","journal-title":"Brain"},{"key":"10.1086\/491749_bib27","first-page":"482","article-title":"Multilocus linkage analysis in humans: detection of linkage and estimation of recombination","volume":"37","author":"Lathrop","year":"1985","journal-title":"Am J Hum Genet"},{"key":"10.1086\/491749_bib28","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1086\/491749_bib29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1086\/491749_bib30","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1136\/bmj.310.6985.970","article-title":"Prevalence of Alzheimer\u2019s disease and vascular dementia: association with education: the Rotterdam study","volume":"310","author":"Ott","year":"1995","journal-title":"BMJ"},{"key":"10.1086\/491749_bib31","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/oxfordjournals.aje.a009489","article-title":"Incidence and risk of dementia: the Rotterdam Study","volume":"147","author":"Ott","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1086\/491749_bib32","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0531-5565(00)00196-0","article-title":"Identification of novel genes in late-onset Alzheimer\u2019s disease","volume":"35","author":"Pericak-Vance","year":"2000","journal-title":"Exp Gerontol"},{"key":"10.1086\/491749_bib33","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/sj.mp.4001198","article-title":"Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval","volume":"7","author":"Rademakers","year":"2002","journal-title":"Mol Psychiatry"},{"key":"10.1086\/491749_bib34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/humu.10269","article-title":"Tau (MAPT) mutation Arg406Trp presenting clinically with Alzheimer disease does not share a common founder in Western Europe","volume":"22","author":"Rademakers","year":"2003","journal-title":"Hum Mutat"},{"key":"10.1086\/491749_bib35","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer\u2019s disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer\u2019s disease type 3 gene","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"10.1086\/491749_bib36","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0304-3940(99)00861-7","article-title":"Mutation screening of the tau gene in patients with early-onset Alzheimer\u2019s disease","volume":"277","author":"Roks","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1086\/491749_bib37","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1212\/WNL.43.8.1467","article-title":"Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer\u2019s disease","volume":"43","author":"Saunders","year":"1993","journal-title":"Neurology"},{"key":"10.1086\/491749_bib38","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer\u2019s disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1086\/491749_bib39","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/archneur.55.7.964","article-title":"Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study","volume":"55","author":"Slooter","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1086\/491749_bib40","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/491749_bib41","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/ng0594-74","article-title":"Apolipoprotein E4 allele in a population-based study of early-onset Alzheimer\u2019s disease","volume":"7","author":"van Duijn","year":"1994","journal-title":"Nat Genet"},{"key":"10.1086\/491749_bib42","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/0140-6736(91)91611-W","article-title":"Amyloid precursor protein gene mutation in early-onset Alzheimer\u2019s disease","volume":"337","author":"van Duijn","year":"1991","journal-title":"Lancet"},{"key":"10.1086\/491749_bib43","first-page":"714","article-title":"A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21","volume":"55","author":"van Duijn","year":"1994","journal-title":"Am J Hum Genet"},{"key":"10.1086\/491749_bib44","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1086\/302710","article-title":"The number of trait loci in late-onset Alzheimer disease","volume":"66","author":"Warwick","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1086\/491749_bib45","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1093\/bioinformatics\/bti006","article-title":"SNPbox, a modular software package for large-scale primer design","volume":"21","author":"Weckx","year":"2005","journal-title":"Bioinformatics"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292970761012X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000292970761012X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T07:55:49Z","timestamp":1548143749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000292970761012X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S000292970761012X"],"URL":"https:\/\/doi.org\/10.1086\/491749","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}