{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:02:32Z","timestamp":1790751752292,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":2756,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1086\/498851","type":"journal-article","created":{"date-parts":[[2005,12,7]],"date-time":"2005-12-07T15:52:06Z","timestamp":1133970726000},"page":"78-88","source":"Crossref","is-referenced-by-count":133,"title":["A Scan of Chromosome 10 Identifies a Novel Locus Showing Strong Association with Late-Onset Alzheimer Disease"],"prefix":"10.1016","volume":"78","author":[{"given":"Andrew","family":"Grupe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Nowotny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony L.","family":"Hinrichs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Smemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.K.","family":"Kauwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor J.","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Cherny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Doil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Tacey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"van Luchene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Wavrant-De Vri\u00e8ze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Kaleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hollingworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Jehu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Foy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Archer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Holmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Catanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sninsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"O\u2019Donovan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lovestone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Thal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Goate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/498851_bib4","series-title":"Categorical data analysis","author":"Agresti","year":"1990"},{"key":"10.1086\/498851_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00439-001-0652-8","article-title":"Investigation of the functional effect of monoamine oxidase polymorphisms in human brain","volume":"110","author":"Balciuniene","year":"2002","journal-title":"Hum Genet"},{"key":"10.1086\/498851_bib6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/archneur.55.3.326","article-title":"Clinicopathologic studies in cognitively healthy aging and Alzheimer\u2019s disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype","volume":"55","author":"Berg","year":"1998","journal-title":"Arch Neurol"},{"key":"10.1086\/498851_bib7","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1126\/science.290.5500.2302","article-title":"Evidence for genetic linkage of Alzheimer\u2019s disease to chromosome 10q","volume":"290","author":"Bertram","year":"2000","journal-title":"Science"},{"key":"10.1086\/498851_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/hmg\/ddg007","article-title":"Results of a high-resolution genome screen of 437 Alzheimer\u2019s disease families","volume":"12","author":"Blacker","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1086\/498851_bib9","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1073\/pnas.0308512100","article-title":"Incipient Alzheimer\u2019s disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses","volume":"101","author":"Blalock","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/498851_bib10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1385\/NMM:5:2:133","article-title":"\u03b1-t-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer\u2019s disease","volume":"5","author":"Busby","year":"2004","journal-title":"Neuromolecular Med"},{"key":"10.1086\/498851_bib11","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1046\/j.1365-294x.2000.01020.x","article-title":"TCS: a computer program to estimate gene genealogies","volume":"9","author":"Clement","year":"2000","journal-title":"Mol Ecol"},{"key":"10.1086\/498851_bib12","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1086\/498851_bib13","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1126\/science.290.5500.2303","article-title":"Linkage of plasma A\u03b242 to a quantitative locus on chromosome 10 in late-onset Alzheimer\u2019s disease pedigrees","volume":"290","author":"Ertekin-Taner","year":"2000","journal-title":"Science"},{"key":"10.1086\/498851_bib14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/hmg\/ddg037","article-title":"Identification of multiple loci for Alzheimer disease in a consanguineous Israeli-Arab community","volume":"12","author":"Farrer","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1086\/498851_bib15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1101\/gr.10.2.258","article-title":"High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR","volume":"10","author":"Germer","year":"2000","journal-title":"Genome Res"},{"key":"10.1086\/498851_bib16","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer\u2019s disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1086\/498851_bib17","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1046\/j.1471-4159.2004.02286.x","article-title":"The three Sorcs genes are differentially expressed and regulated by synaptic activity","volume":"88","author":"Hermey","year":"2004","journal-title":"J Neurochem"},{"key":"10.1086\/498851_bib18","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/bbrc.1999.1822","article-title":"Identification and characterization of SorCS, a third member of a novel receptor family","volume":"266","author":"Hermey","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1086\/498851_bib19","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1182\/blood.V95.3.1047.003k43_1047_1055","article-title":"Regulation of drug sensitivity by ribosomal protein S3a","volume":"95","author":"Hu","year":"2000","journal-title":"Blood"},{"key":"10.1086\/498851_bib20","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/hmg\/8.2.237","article-title":"A full genome scan for late onset Alzheimer\u2019s disease","volume":"8","author":"Kehoe","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1086\/498851_bib21","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/hmg\/11.12.1477","article-title":"Common haplotypes in five genes influence genetic variance of LDL and HDL cholesterol in the general population","volume":"11","author":"Knoblauch","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1086\/498851_bib22","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1086\/498851_bib23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/humu.20138","article-title":"Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease","volume":"25","author":"Li","year":"2005","journal-title":"Hum Mutat"},{"key":"10.1086\/498851_bib24","doi-asserted-by":"crossref","first-page":"15688","DOI":"10.1073\/pnas.0403535101","article-title":"Association of late-onset Alzheimer\u2019s disease with genetic variation in multiple members of the GAPD gene family","volume":"101","author":"Li","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/498851_bib25","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer\u2019s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer\u2019s Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1086\/498851_bib26","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1126\/science.290.5500.2304","article-title":"Susceptibility locus for Alzheimer\u2019s disease on chromosome 10","volume":"290","author":"Myers","year":"2000","journal-title":"Science"},{"key":"10.1086\/498851_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ajmg.10183","article-title":"Full genome screen for Alzheimer disease: stage II analysis","volume":"114","author":"Myers","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1086\/498851_bib28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ajmg.b.20036","article-title":"Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD","volume":"124","author":"Myers","year":"2004","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1086\/498851_bib29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/ajmg.b.30186","article-title":"Association studies between risk for late-onset Alzheimer\u2019s disease and variants in insulin degrading enzyme","volume":"136","author":"Nowotny","year":"2005","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1086\/498851_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s11920-004-0052-6","article-title":"Molecular genetics of Alzheimer\u2019s disease","volume":"6","author":"Pastor","year":"2004","journal-title":"Curr Psychiatry Rep"},{"key":"10.1086\/498851_bib31","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jama.1997.03550150041033","article-title":"Complete genomic screen in late-onset familial Alzheimer disease: evidence for a new locus on chromosome 12","volume":"278","author":"Pericak-Vance","year":"1997","journal-title":"JAMA"},{"key":"10.1086\/498851_bib32","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0531-5565(00)00196-0","article-title":"Identification of novel genes in late-onset Alzheimer\u2019s disease","volume":"35","author":"Pericak-Vance","year":"2000","journal-title":"Exp Gerontol"},{"key":"10.1086\/498851_bib33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1001\/jama.280.7.614","article-title":"Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity","volume":"280","author":"Rogaeva","year":"1998","journal-title":"JAMA"},{"key":"10.1086\/498851_bib34","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer\u2019s disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1086\/498851_bib35","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1021\/bi015669c","article-title":"Inhibition of poly(ADP-ribose) polymerase activity by Bcl-2 in association with the ribosomal protein S3a","volume":"41","author":"Song","year":"2002","journal-title":"Biochemistry"},{"key":"10.1086\/498851_bib36","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/379378","article-title":"A comparison of Bayesian methods for haplotype reconstruction from population genotype data","volume":"73","author":"Stephens","year":"2003","journal-title":"Am J Hum Genet"},{"key":"10.1086\/498851_bib37","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1086\/319501","article-title":"A new statistical method for haplotype reconstruction from population data","volume":"68","author":"Stephens","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1086\/498851_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1534\/genetics.104.030080","article-title":"Tree scanning: a method for using haplotype trees in phenotype\/genotype association studies","volume":"169","author":"Templeton","year":"2005","journal-title":"Genetics"},{"key":"10.1086\/498851_bib39","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/genetics\/156.3.1259","article-title":"Cladistic structure within the human lipoprotein lipase gene and its implications for phenotypic association studies","volume":"156","author":"Templeton","year":"2000","journal-title":"Genetics"},{"key":"10.1086\/498851_bib40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature00878","article-title":"Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness","volume":"418","author":"Van Eerdewegh","year":"2002","journal-title":"Nature"},{"key":"10.1086\/498851_bib41","series-title":"Resampling-based multiple testing","author":"Westfall","year":"1993"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707608076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707608076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T02:54:52Z","timestamp":1626836092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707608076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0002929707608076"],"URL":"https:\/\/doi.org\/10.1086\/498851","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}