{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:49:20Z","timestamp":1780663760200,"version":"3.54.1"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"unspecified","delay-in-days":3824,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:sec id=\"S0899823X00194206_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To evaluate the efficacy of silicone-based, silver ion\u2013impregnated urinary catheters in the prevention of nosocomial urinary tract infections (NUTIs).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00194206_abs2\"><jats:title>Design.<\/jats:title><jats:p>Prospective, crossover study to compare the efficacy of a silicone-based, hydrogel-coated, silver-impregnated Foley catheter with that of a silicone-based, hydrogel-coated catheter in the prevention of NUTIs.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00194206_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Adult medical and surgical wards of a university teaching hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00194206_abs4\"><jats:title>Results.<\/jats:title><jats:p>A total of 3,036 patients with catheters were evaluated; 1,165 (38%) of the catheters were silver impregnated, and 1,871 (62%) were not silver impregnated. Study groups were not identical; there were more men, a shorter duration of catheterization, and fewer urine cultures per 1,000 catheter-days in the silver catheter group. The rate of NUTIs per 1,000 Foley-days was 14.29 in the silver catheter group, compared with 16.15 in the nonsilver catheter group (incidence rate ratio, 0.88; 95% confidence interval, 0.70-1.11;<jats:italic>P<\/jats:italic>= .29). The median length of catheterization prior to the onset of a urinary tract infection (ie, exposure time) was 4 days for each group. There were no differences in the recovery of gram-positive, gram-negative, or fungal organisms in NUTIs. In a multivariate survival analysis, no factors, including silver catheters, were protective against NUTI.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00194206_abs5\"><jats:title>Conclusions.<\/jats:title><jats:p>Unlike previous trials of latex-based, silver ion\u2013impregnated Foley catheters, we found that silicone-based, silver-impregnated Foley catheters were not effective in preventing NUTIs; however, this study was affected by differences in the study groups. Prospective trials remain important in assessing the efficacy and cost-effectiveness of new silver-coated products.<\/jats:p><\/jats:sec>","DOI":"10.1086\/499998","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T17:52:46Z","timestamp":1136829166000},"page":"38-43","source":"Crossref","is-referenced-by-count":88,"title":["A Prospective Trial of a Novel, Silicone-Based, Silver-Coated Foley Catheter for the Prevention of Nosocomial Urinary Tract 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