{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:35:04Z","timestamp":1789979704831,"version":"4.0.1"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":5694,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:sec id=\"S0195941700070430_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To determine the attributable hospital stay and costs for nosocomial methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant<jats:italic>S aureus<\/jats:italic>(MRSA) primary bloodstream infections (BSIs).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700070430_abs2\"><jats:title>Design:<\/jats:title><jats:p>Pairwise-matched (1:1) nested case-control study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700070430_abs3\"><jats:title>Setting:<\/jats:title><jats:p>University-based tertiary-care medical center.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700070430_abs4\"><jats:title>Patients:<\/jats:title><jats:p>Patients admitted between December 1993 and March 1995 were eligible. Cases were defined as patients with a primary nosocomial<jats:italic>S aureus<\/jats:italic>BSI; controls were selected according to a priori matching criteria.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700070430_abs5\"><jats:title>Measurements:<\/jats:title><jats:p>Length of hospital stay and total and variable direct costs of hospitalization.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700070430_abs6\"><jats:title>Results:<\/jats:title><jats:p>The median hospital stay attributable to primary nosocomial MSSA BSI was 4 days, compared with 12 days for MRSA (<jats:italic>P<\/jats:italic>=.023). Attributable median total cost for MSSA primary nosocomial BSIs was $9,661 versus $27,083 for MRSA nosocomial infections (<jats:italic>P<\/jats:italic>=.043).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700070430_abs7\"><jats:title>Conclusion:<\/jats:title><jats:p>Nosocomial primary BSI due to<jats:italic>S aureus<\/jats:italic>significantly prolongs the hospital stay. Primary nosocomial BSIs due to MRSA result in an approximate threefold increase in direct cost, compared with those due to MSSA.<\/jats:p><\/jats:sec>","DOI":"10.1086\/501641","type":"journal-article","created":{"date-parts":[[2006,2,3]],"date-time":"2006-02-03T19:29:41Z","timestamp":1138994981000},"page":"408-411","source":"Crossref","is-referenced-by-count":251,"title":["Nosocomial Methicillin-Resistant and Methicillin-Susceptible<i>Staphylococcus Aureus<\/i>Primary Bacteremia: At What Costs?"],"prefix":"10.1017","volume":"20","author":[{"given":"Murray A.","family":"Abramson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Sexton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700070430_ref012","volume-title":"Cost Management Participant's Guide","year":"1993"},{"key":"S0195941700070430_ref020","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.6.1227"},{"key":"S0195941700070430_ref011","volume-title":"International Classification of Diseases","year":"1989"},{"key":"S0195941700070430_ref022","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.4.685"},{"key":"S0195941700070430_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90349-3"},{"key":"S0195941700070430_ref006","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197711000-00005"},{"key":"S0195941700070430_ref002","doi-asserted-by":"publisher","DOI":"10.2307\/30148460"},{"key":"S0195941700070430_ref018","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-9-674"},{"key":"S0195941700070430_ref010","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380120094019"},{"key":"S0195941700070430_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/17.1.225"},{"key":"S0195941700070430_ref017","doi-asserted-by":"publisher","DOI":"10.2307\/30148461"},{"key":"S0195941700070430_ref009","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1128\/JCM.25.4.734-735.1987","article-title":"Effect of source of Mueller-Hinton agar on detection of oxacillin resistance in Staphylococcus aureus using a screening methodology","volume":"25","author":"Hindler","year":"1997","journal-title":"J Clin Microbiol"},{"key":"S0195941700070430_ref003","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510440058033"},{"key":"S0195941700070430_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(85)80011-0"},{"key":"S0195941700070430_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0195941700053881"},{"key":"S0195941700070430_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90058-2"},{"key":"S0195941700070430_ref021","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/159.5.989"},{"key":"S0195941700070430_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.4.897"},{"key":"S0195941700070430_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(90)90120-D"},{"key":"S0195941700070430_ref015","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-93-4-526"},{"key":"S0195941700070430_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"S0195941700070430_ref019","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-4-496"},{"key":"S0195941700070430_ref007","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1978.03290220067020"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700070430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T12:41:59Z","timestamp":1586695319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700070430\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["S0195941700070430"],"URL":"https:\/\/doi.org\/10.1086\/501641","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}