{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T08:02:20Z","timestamp":1789372940307,"version":"build-2803163510"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":5664,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[1999,7]]},"abstract":"<jats:sec id=\"S019594170006896X_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate efficacy of laminar airflow facilities plus high-efficiency particulate air (HEPA) filtration and HEPA filtration alone in preventing environmental<jats:italic>Aspergillus<\/jats:italic>contamination during hospital renovation. To show the usefulness of environmental surveillance to facilitate protection of patients at risk for invasive pulmonary aspergillosis.<\/jats:p><\/jats:sec><jats:sec id=\"S019594170006896X_abs2\"><jats:title>Design:<\/jats:title><jats:p>Prospective sampling of air and surfaces for<jats:italic>Aspergillus<\/jats:italic>conidia during 2-year period.<\/jats:p><\/jats:sec><jats:sec id=\"S019594170006896X_abs3\"><jats:title>Setting:<\/jats:title><jats:p>A hematological department adjacent to building renovation at a university hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S019594170006896X_abs4\"><jats:title>Results:<\/jats:title><jats:p>1,047 air samples and 1,178 surface samples were collected from January 1996 to December 1997. Significantly more air samples were positive for<jats:italic>Aspergillus<\/jats:italic>species during the period of building renovation than during the periods before and after renovation in a unit without a protected air supply adjacent to the building work area (51.5% vs 31.7%; odds ratio [OR], 2.3; 95% confidence interval [CI<jats:sub>95<\/jats:sub>, 1.4-3.7;<jats:italic>P<\/jats:italic>&lt;.001). A major increase in the frequency of positive air samples was also found in another adjacent unit that was protected with HEPA filtration alone (from 1.8% to 47.5%; OR, 48.9; CI<jats:sub>95<\/jats:sub>,12-229;<jats:italic>P<\/jats:italic>&lt;10<jats:sup>-7<\/jats:sup>). In addition, in this unit, the mean count of<jats:italic>Aspergillus<\/jats:italic>conidia in positive air samples increased significantly during construction (4 colony-forming units [CFU]\/m<jats:sup>3<\/jats:sup>to 24.7 CFU\/m<jats:sup>3<\/jats:sup>;<jats:italic>P<\/jats:italic>=.04) and the proportion of positive surface samples showed a significant increase during renovation (from 0.4% to 9.7%; OR, 28.3; CI<jats:sub>95<\/jats:sub>, 3.4-623;<jats:italic>P<\/jats:italic>=10<jats:sup>4<\/jats:sup>). However, none of 142 air samples collected during renovation in the area protected with laminar airflow plus HEPA filtration showed<jats:italic>Aspergillus<\/jats:italic>conidia. In a unit distant from the building renovation site, the results of air and surface samples were not affected by renovation.<\/jats:p><\/jats:sec><jats:sec id=\"S019594170006896X_abs5\"><jats:title>Conclusion:<\/jats:title><jats:p>This study showed a strong association between building renovation and an increase in environmental<jats:italic>Aspergillus<\/jats:italic>contamination. Results confirmed the high efficacy of laminar airflow plus HEPA filtration and a high air-change rate. Although filtration with HEPA was effective during normal conditions, it alone was unable to prevent the rise of<jats:italic>Aspergillus<\/jats:italic>contamination related to building renovation. This study emphasized the necessity of an environmental survey of airborne contamination related to construction, to facilitate prevention of nosocomial aspergillosis outbreaks. A standardized protocol for aerobiological surveillance is needed.<\/jats:p><\/jats:sec>","DOI":"10.1086\/501661","type":"journal-article","created":{"date-parts":[[2006,2,3]],"date-time":"2006-02-03T20:14:15Z","timestamp":1138997655000},"page":"508-513","source":"Crossref","is-referenced-by-count":119,"title":["Efficacy of Prevention by High-Efficiency Particulate Air Filtration or Laminar Airflow Against Aspergillus Airborne Contamination During Hospital 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