{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:03:11Z","timestamp":1777384991631,"version":"3.51.4"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":5114,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0195941700054084_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To assess the extent of nosocomial transmission and risk factors associated with tuberculin skin test (TST) conversions among healthcare workers (HCWs) exposed to a patient with genitourinary <jats:italic>Mycobacterium tuberculosis<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700054084_abs2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective cohort study of exposed HCWs.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700054084_abs3\"><jats:title>Setting:<\/jats:title><jats:p>A 275-bed community hospital in Middle Tennessee.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700054084_abs4\"><jats:title>Participants:<\/jats:title><jats:p>A total of 128 exposed HCWs and the index patient, who required drainage of a prostatic abscess and bilateral orchiectomy and expired after a 27-day hospitalization. Disseminated tuberculosis was diagnosed at autopsy.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700054084_abs5\"><jats:title>Methods:<\/jats:title><jats:p>Contact tracing was performed on exposed HCWs. Logistic regression was used to identify independent risk factors associated with TST conversion.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700054084_abs6\"><jats:title>Results:<\/jats:title><jats:p>A total of 128 HCWs were exposed to the index patient. There was no evidence of active pulmonary tuberculosis throughout the patient's hospitalization; TST conversions occurred only among HCWs who were exposed to the patient during or after his surgical procedures. A total of 12 (13%) of 95 exposed HCWs who were previously nonreactive had newly positive TST: 6 of 28 nurses, 3 of 3 autopsy personnel, 2 of 17 respiratory therapists, and 1 of 12 surgical staff. By logistic regression, irrigation or packing of the surgical site was the only independent risk factor associated with TST conversion among nurses (odds ratio, 9; 95% confidence interval, 1.2-67; <jats:italic>P<\/jats:italic>=.03).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700054084_abs7\"><jats:title>Conclusion:<\/jats:title><jats:p>Manipulation of infected tissues of the genitourinary tract can result in nosocomial transmission of tuberculosis.<\/jats:p><\/jats:sec>","DOI":"10.1086\/501817","type":"journal-article","created":{"date-parts":[[2006,2,17]],"date-time":"2006-02-17T19:01:58Z","timestamp":1140202918000},"page":"10-12","source":"Crossref","is-referenced-by-count":24,"title":["Nosocomial Transmission of <i>Mycobacterium tuberculosis<\/i> From an Extrapulmonary Site"],"prefix":"10.1017","volume":"22","author":[{"given":"Erika M.C.","family":"D'Agata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Wise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Lewis B.","family":"Lefkowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700054084_ref013","doi-asserted-by":"publisher","DOI":"10.2307\/30142367"},{"key":"S0195941700054084_ref004","first-page":"1073","article-title":"Transmission of a highly drug-resistant strain (strain W1) of Mycobacterium tuberculosis: community outbreak and nosocomial transmission via a contaminated bronchoscope","volume":"278","author":"Agerton","year":"1997","journal-title":"Ann Intern Med"},{"key":"S0195941700054084_ref007","first-page":"9","article-title":"Diagnostic standards and classification of tuberculosis","volume":"39","year":"1990","journal-title":"Am Rev Sespir Dis"},{"key":"S0195941700054084_ref012","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198401000-00003"},{"key":"S0195941700054084_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90060-5"},{"key":"S0195941700054084_ref010","doi-asserted-by":"publisher","DOI":"10.1086\/501749"},{"key":"S0195941700054084_ref001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501123320206"},{"key":"S0195941700054084_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/168.4.1052"},{"key":"S0195941700054084_ref009","first-page":"41","article-title":"Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care facilities","volume":"43","year":"1994","journal-title":"MMWR"},{"key":"S0195941700054084_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.2.286"},{"key":"S0195941700054084_ref006","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-4-312"},{"key":"S0195941700054084_ref003","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1995.00430080100012"},{"key":"S0195941700054084_ref008","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-12-199506150-00005"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700054084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T19:37:01Z","timestamp":1557344221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700054084\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0195941700054084"],"URL":"https:\/\/doi.org\/10.1086\/501817","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}