{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:50:28Z","timestamp":1774565428972,"version":"3.50.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":4476,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:sec id=\"S0195941700081364_abs1\"><jats:title>Objective:<\/jats:title><jats:p>We report a case of congenital tuberculosis in a neonatal intensive care unit (NICU) and the management of exposure to other neonates in the hospital. We review the literature regarding congenital tuberculosis and management of exposures in the NICU.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700081364_abs2\"><jats:title>Design:<\/jats:title><jats:p>Case report and a survey of exposures with a 3-month follow-up.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700081364_abs3\"><jats:title>Setting:<\/jats:title><jats:p>Urban hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700081364_abs4\"><jats:title>Patients:<\/jats:title><jats:p>Neonates exposed to a case of congenital tuberculosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700081364_abs5\"><jats:title>Interventions:<\/jats:title><jats:p>Exposure to tuberculosis was treated with isoniazid. Purified protein derivative tests were placed at base-line and 3 to 4 months after exposure. Chest radiographs were performed if clinically indicated.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700081364_abs6\"><jats:title>Results:<\/jats:title><jats:p>Congenital tuberculosis was diagnosed in our patient at 21 days of age during a prolonged hospital course. After initiation of anti-tuberculous medications, the patient gradually recovered from his illness. While he was treated in the NICU, there were 37 potentially exposed infants. Of these, 36 were administered tuberculin skin tests (average age, 1.7 months), all of which were read as 0 mm of induration. Of those 37, 35 began prophylaxis with isoniazid, and 30 were able to complete treatment with a minimum of 3 months of isoniazid therapy. Of those 30, two infants received 6 months of therapy. Additionally, 29 of the 37 infants had chest radiographs, none of which showed suspicious infiltrates or adenopathy. Finally, 30 of the 36 infants had repeat tuberculin skin tests at 3 months, all of which were read as 0 mm of induration (average age, 3.7 months).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700081364_abs7\"><jats:title>Conclusion:<\/jats:title><jats:p>Congenital tuberculosis is an uncommon disease that requires early diagnosis for successful therapy and vigilant follow-up of potential exposures in the NICU. (Infect Control Hosp Epidemiol 2002;23:573-579).<\/jats:p><\/jats:sec>","DOI":"10.1086\/501973","type":"journal-article","created":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T15:41:32Z","timestamp":1140536492000},"page":"573-579","source":"Crossref","is-referenced-by-count":36,"title":["Congenital Tuberculosis and Management of Exposures in a Neonatal Intensive Care Unit"],"prefix":"10.1017","volume":"23","author":[{"given":"Brent W.","family":"Laartz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo J.","family":"Narvarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Holt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Larkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"William F.","family":"Pomputius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700081364_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(84)90057-6"},{"key":"S0195941700081364_ref020","first-page":"415","article-title":"Management of newborns after nursery exposure to tuberculosis","volume":"109","author":"Light","year":"1974","journal-title":"American Review of Respiratory Disease"},{"key":"S0195941700081364_ref013","doi-asserted-by":"publisher","DOI":"10.1136\/fn.77.1.F77a"},{"key":"S0195941700081364_ref024","first-page":"55","volume-title":"Core Curriculum on Tuberculosis","year":"2000"},{"key":"S0195941700081364_ref014","first-page":"50","article-title":"Perinatal tuberculosis and its public health impact a case report","volume":"92","author":"Spark","year":"1996","journal-title":"Tex Med"},{"key":"S0195941700081364_ref019","first-page":"609","volume-title":"1996 Red Book: Report of the Committee on Infectious Diseases","author":"Pickering","year":"1996"},{"key":"S0195941700081364_ref001","first-page":"732","article-title":"Progress towards the elimination of tuberculosis: United States, 1998","volume":"48","year":"1999","journal-title":"MMWR"},{"key":"S0195941700081364_ref018","first-page":"51","article-title":"Congenital tuberculosis: an underdiagnosed entity","volume":"33","author":"Verma","year":"1996","journal-title":"Indian Pediatr"},{"key":"S0195941700081364_ref009","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199711000-00017"},{"key":"S0195941700081364_ref011","doi-asserted-by":"publisher","DOI":"10.1086\/514690"},{"key":"S0195941700081364_ref002","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520270054031"},{"key":"S0195941700081364_ref004","doi-asserted-by":"publisher","DOI":"10.1136\/thx.10.2.99"},{"key":"S0195941700081364_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13804.x"},{"key":"S0195941700081364_ref021","first-page":"267","article-title":"Miliary tuberculosis in two infants after nursery exposure: epidemiologic, clinical, and laboratory findings","volume":"113","author":"Steiner","year":"1976","journal-title":"American Review of Respiratory Disease"},{"key":"S0195941700081364_ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.1998.tb00512.x"},{"key":"S0195941700081364_ref012","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199712000-00003"},{"key":"S0195941700081364_ref023","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1542\/peds.67.1.89","article-title":"Tuberculosis in pregnancy with fatal congenital infection","volume":"67","author":"Myers","year":"1981","journal-title":"Pediatrics"},{"key":"S0195941700081364_ref005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199404143301505"},{"key":"S0195941700081364_ref017","doi-asserted-by":"publisher","DOI":"10.1007\/BF02751909"},{"key":"S0195941700081364_ref022","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197801000-00004"},{"key":"S0195941700081364_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0962-8479(95)90015-2"},{"key":"S0195941700081364_ref015","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199608000-00025"},{"key":"S0195941700081364_ref006","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1542\/peds.66.6.980","article-title":"Congenital tuberculosis: critical reappraisal of clinical findings and diagnostic procedures","volume":"66","author":"Hageman","year":"1980","journal-title":"Pediatrics"},{"key":"S0195941700081364_ref007","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199408000-00012"}],"container-title":["Infection Control &amp; 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