{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:24:02Z","timestamp":1775075042600,"version":"3.50.1"},"reference-count":52,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":4415,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:sec id=\"S0195941700080541_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To identify antibiotic resistance trends and risk factors for resistance of<jats:italic>Serratia<\/jats:italic>species to third-generation cephalosporins.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080541_abs2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective survey of medical records.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080541_abs3\"><jats:title>Setting:<\/jats:title><jats:p>A 2,200-bed, tertiary-care hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080541_abs4\"><jats:title>Patients:<\/jats:title><jats:p>One hundred twenty-two patients with<jats:italic>Serratia<\/jats:italic>bacteremia between January 1991 and June 2001.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080541_abs5\"><jats:title>Methods:<\/jats:title><jats:p>Infectious disease physicians collected data from medical records regarding patient demographics, underlying disease or condition, portal of entry, microorganism, antibiogram, complications, antibiotics received, and outcome.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080541_abs6\"><jats:title>Results:<\/jats:title><jats:p>Among 122<jats:italic>Serratia<\/jats:italic>isolates, 117 (95.9%) were<jats:italic>Serratia<\/jats:italic>marcescens and 110 (90.2%) were of nosocomial origin. During the study period, the 122 isolates showed a high rate of resistance to third-generation cephalosporins (45.9%) and extended-spectrum penicillins (56.6%). The resistance rate to ciprofloxacin was 32.0%. The resistance rate to third-generation cephalosporins increased from 31.7% for 1991 to 1995 to 54.9% for 1996 to 1998 and 50.0% for 1999 to 2001. In the multivariate analysis, prior use of a second-generation cephalosporin (adjusted odds ratio [OR], 5.90; 95% confidence interval [CI<jats:sub>95<\/jats:sub>], 1.41 to 24.6;<jats:italic>P<\/jats:italic>= .015) or a third-generation cephalosporin (OR, 3.26; CI<jats:sub>95<\/jats:sub>, 1.20 to 8.87;<jats:italic>P<\/jats:italic>= .020) was a strong independent risk factor for resistance to third-generation cephalosporins. The overall case-fatality rate was 25.4% (<jats:italic>Serratia<\/jats:italic>bacteremia-related case-fatality rate, 13.1%).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080541_abs7\"><jats:title>Conclusion:<\/jats:title><jats:p>Prior use of a second- or third-generation cephalosporin was the most important risk factor for bacteremia with<jats:italic>Serratia<\/jats:italic>resistant to third-generation cephalosporins, suggesting the need for antibiotic control. The potential role of patient-to-patient spread could not be fully evaluated in this retrospective study.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502004","type":"journal-article","created":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T15:53:31Z","timestamp":1140537211000},"page":"740-747","source":"Crossref","is-referenced-by-count":30,"title":["<i>Serratia<\/i>Bacteremia in a Large University Hospital: Trends in Antibiotic Resistance During 10 Years and Implications for Antibiotic Use"],"prefix":"10.1017","volume":"23","author":[{"given":"Sang-Ho","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Won","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Hyong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ju","family":"Choo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Na","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baek-Nam","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Joong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Hee","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiso","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700080541_ref020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196808082790604"},{"key":"S0195941700080541_ref029","first-page":"171","article-title":"Serratia marcescens bacteremia: clinical features and antimicrobial susceptibilities of the isolates","volume":"31","author":"Yu","year":"1998","journal-title":"J Microbiol Immunol Infect"},{"key":"S0195941700080541_ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(87)90138-6"},{"key":"S0195941700080541_ref041","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.6.517"},{"key":"S0195941700080541_ref015","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013107"},{"key":"S0195941700080541_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(98)00029-7"},{"key":"S0195941700080541_ref038","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-119-5-199309010-00001"},{"key":"S0195941700080541_ref012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105173442001"},{"key":"S0195941700080541_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70395-0"},{"key":"S0195941700080541_ref005","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1128\/JCM.15.4.728-730.1982","article-title":"Nosocomial outbreak of nitrate-negative Serratia marcescens infections","volume":"15","author":"Geiseler","year":"1982","journal-title":"J Clin Microbiol"},{"key":"S0195941700080541_ref031","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-8-585"},{"key":"S0195941700080541_ref006","doi-asserted-by":"publisher","DOI":"10.3109\/00313028409059103"},{"key":"S0195941700080541_ref049","first-page":"21","article-title":"Lipopolysaccharide recovery restores susceptibility levels towards \u03b2-lactamase in Serratia marcescens","volume":"82","author":"Palomar","year":"1995","journal-title":"Microbios"},{"key":"S0195941700080541_ref050","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(05)70295-9"},{"key":"S0195941700080541_ref022","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1971.00310200083008"},{"key":"S0195941700080541_ref001","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.1.203"},{"key":"S0195941700080541_ref019","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1968.03640020033006"},{"key":"S0195941700080541_ref009","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400160129025"},{"key":"S0195941700080541_ref025","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/11.6.912"},{"key":"S0195941700080541_ref030","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1962.03620240038007"},{"key":"S0195941700080541_ref046","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.4.830"},{"key":"S0195941700080541_ref051","doi-asserted-by":"publisher","DOI":"10.1086\/514747"},{"key":"S0195941700080541_ref052","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.9.2628-2630.2001"},{"key":"S0195941700080541_ref011","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2001.0941"},{"key":"S0195941700080541_ref045","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199805000-00016"},{"key":"S0195941700080541_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.5.824"},{"key":"S0195941700080541_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(98)94171-8"},{"key":"S0195941700080541_ref024","first-page":"479","article-title":"Serratia marcescens bacteremia: a report of 83 cases [in Spanish]","volume":"90","author":"Sanchez Ruano","year":"1988","journal-title":"Medica Clinica"},{"key":"S0195941700080541_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(10)64424-4"},{"key":"S0195941700080541_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(97)00064-3"},{"key":"S0195941700080541_ref007","first-page":"438","article-title":"Serratial bacteremia in the surgical patient","volume":"53","author":"Fry","year":"1987","journal-title":"Am Surg"},{"key":"S0195941700080541_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(91)90088-P"},{"key":"S0195941700080541_ref003","doi-asserted-by":"publisher","DOI":"10.1086\/520192"},{"key":"S0195941700080541_ref037","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5520(05)70249-X"},{"key":"S0195941700080541_ref040","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.3.529"},{"key":"S0195941700080541_ref048","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1262"},{"key":"S0195941700080541_ref013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197904193001604"},{"key":"S0195941700080541_ref014","first-page":"2297","volume-title":"Principles and Practice of Infectious Diseases","author":"Eisenstein","year":"2000"},{"key":"S0195941700080541_ref017","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.2.153"},{"key":"S0195941700080541_ref008","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1128\/JCM.27.11.2433-2436.1989","article-title":"Epidemic of Serratia marcescens bacteremia in a cardiac intensive care unit","volume":"27","author":"Villarino","year":"1989","journal-title":"J Clin Microbiol"},{"key":"S0195941700080541_ref028","first-page":"273","article-title":"Nosocomial infection in the community hospital: severe infection due to Serratia species","volume":"42","author":"Haddy","year":"1996","journal-title":"J Fam Pract"},{"key":"S0195941700080541_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(97)90115-8"},{"key":"S0195941700080541_ref027","first-page":"88","article-title":"Serratia marcescens bacteremia","volume":"90","author":"Wong","year":"1991","journal-title":"J Formos Med Assoc"},{"key":"S0195941700080541_ref026","doi-asserted-by":"publisher","DOI":"10.3109\/00365548909037874"},{"key":"S0195941700080541_ref043","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00044-2"},{"key":"S0195941700080541_ref032","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: Ninth Informational Supplement M100-S9","year":"1999"},{"key":"S0195941700080541_ref039","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1128\/AAC.42.1.53","article-title":"Epidemiology and successful control of a large outbreak due to Klebsiella pneumoniae producing extended-spectrum beta-lactamases","volume":"42","author":"Pena","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"S0195941700080541_ref044","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.5.1107"},{"key":"S0195941700080541_ref047","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/29.6.609"},{"key":"S0195941700080541_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/BF02013110"},{"key":"S0195941700080541_ref042","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.8.4.557","article-title":"Beta-lactamases in laboratory and clinical resistance","volume":"8","author":"Livermore","year":"1995","journal-title":"Clin Microbiol Rev"},{"key":"S0195941700080541_ref021","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-197105000-00006"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700080541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T20:57:38Z","timestamp":1586725058000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700080541\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["S0195941700080541"],"URL":"https:\/\/doi.org\/10.1086\/502004","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}