{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T02:46:21Z","timestamp":1771987581570,"version":"3.50.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":4080,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0195941700078978_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate a possible nosocomial outbreak of tuberculosis (TB).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700078978_abs2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700078978_abs3\"><jats:title>Setting:<\/jats:title><jats:p>Community hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700078978_abs4\"><jats:title>Methods:<\/jats:title><jats:p>We reviewed medical records, hospital infection control measures, and potential locations of nosocomial exposure. We examined the results of acid-fast bacilli (AFB) smears, cultures, and drug susceptibility testing, and performed a DNA fingerprint analysis. We observed laboratory specimen processing procedures and bronchoscope disinfection procedures. We also reviewed bronchoscopy records.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700078978_abs5\"><jats:title>Results:<\/jats:title><jats:p>In October 2000, three patients had bronchoscopy specimen cultures that were positive for<jats:italic>Mycobacterium tuberculosis.<\/jats:italic>Of the three, only one had clinical signs and symptoms consistent with TB and positive AFB sputum smears. The other two did not have signs and symptoms consistent with TB and had no known exposure to individuals with infectious TB. The three<jats:italic>M. tuberculosis<\/jats:italic>isolates had matching DNA fingerprints. No evidence of laboratory cross-contamination was identified. The three culture-positive specimens of<jats:italic>M. tuberculosis<\/jats:italic>were collected with the same bronchoscope within 9 days. This bronchoscope was inadequately cleaned and disinfected between patients, and the automated reprocessor used was not approved for use with the hospital bronchoscope.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700078978_abs6\"><jats:title>Conclusions:<\/jats:title><jats:p>One of the bronchoscopes at this hospital was contaminated with<jats:italic>M. tuberculosis<\/jats:italic>during bronchoscopy of an AFB-smear-positive patient. Subsequent specimen contamination likely occurred because the bronchoscope had been inadequately cleaned and disinfected. Patients who subsequently underwent bronchoscopy were also potentially exposed to<jats:italic>M. tuberculosis<\/jats:italic>from this bronchoscope.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502144","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T22:00:56Z","timestamp":1142460056000},"page":"825-830","source":"Crossref","is-referenced-by-count":30,"title":["Potential Nosocomial Exposure to<i>Mycobacterium tuberculosis<\/i>From a Bronchoscope"],"prefix":"10.1017","volume":"24","author":[{"given":"Janet L.","family":"Larson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel L.","family":"Stricof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Driscoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"McGarry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e","family":"Ridzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700078978_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(96)90066-8"},{"key":"S0195941700078978_ref011","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1128\/JCM.35.4.907-914.1997","article-title":"Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and 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1998","volume":"48","year":"1999","journal-title":"MMWR"},{"key":"S0195941700078978_ref016","first-page":"1","article-title":"Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care facilities, 1994","volume":"43","year":"1994","journal-title":"MMWR"},{"key":"S0195941700078978_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90074-L"},{"key":"S0195941700078978_ref020","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.5.1166"},{"key":"S0195941700078978_ref022","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.4_Pt_1.853"},{"key":"S0195941700078978_ref017","first-page":"1","volume-title":"FDA and CDC Public Health Advisory: Infections From Endoscopes Inadequately Reprocessed by an Automated Endoscope Reprocessing System","year":"1999"},{"key":"S0195941700078978_ref002","first-page":"89","volume-title":"Ending Neglect: The Elimination of Tuberculosis in the United 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