{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T19:44:26Z","timestamp":1790538266712,"version":"4.1.0"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":4050,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0195941700083600_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate excess mortality in critically ill patients with <jats:italic>Escherichia coli<\/jats:italic> bacteremia after adjustment for severity of illness.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083600_abs2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective (1992-2000), pairwise-matched (1:2), risk-adjusted cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083600_abs3\"><jats:title>Setting:<\/jats:title><jats:p>Fifty-four-bed ICU in a university hospital including a medical and surgical ICU, a unit for care after cardiac surgery, and a burns unit.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083600_abs4\"><jats:title>Patients:<\/jats:title><jats:p>ICU patients with nosocomial <jats:italic>E. coli<\/jats:italic> bacteremia (defined as cases; n = 64) and control-patients without nosocomial bloodstream infection (n = 128).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083600_abs5\"><jats:title>Methods:<\/jats:title><jats:p>Case-patients were matched with control-patients on the basis of the Acute Physiology and Chronic Health Evaluation (APACHE) II system: an equal APACHE II score (\u00b1 2 points) and diagnostic category. In addition, control-patients were required to have an ICU stay at least as long as that of the respective case-patients prior to onset of the bacteremia.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083600_abs6\"><jats:title>Results:<\/jats:title><jats:p>The overall rate of appropriate antibiotic therapy in patients with <jats:italic>E. coli<\/jats:italic> bacteremia was high (93%) and such therapy was initiated soon after onset of the bacteremia (0.6 \u00b1 1.0 day). ICU patients with <jats:italic>E. coli<\/jats:italic> bacteremia had more acute renal failure. No differences were noted between case-patients and control-patients in incidence of acute respiratory failure, hemodynamic instability, or age. No differences were observed in length of mechanical ventilation or length of ICU stay. In-hospital mortality rates for cases and controls were not different (43.8% and 45.3%, respectively; <jats:italic>P<\/jats:italic> = .959).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083600_abs7\"><jats:title>Conclusion:<\/jats:title><jats:p>After adjustment for disease severity and acute illness and in the presence of adequate antibiotic therapy, no excess mortality was found in ICU patients with <jats:italic>E. coli<\/jats:italic> bacteremia.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502159","type":"journal-article","created":{"date-parts":[[2006,3,15]],"date-time":"2006-03-15T22:08:14Z","timestamp":1142460494000},"page":"912-915","source":"Crossref","is-referenced-by-count":37,"title":["Absence of Excess Mortality in Critically Ill Patients With Nosocomial <i>Escherichia coli<\/i> Bacteremia"],"prefix":"10.1017","volume":"24","author":[{"given":"Stijn","family":"Blot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koenraad","family":"Vandewoude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hoste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan De","family":"Waele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Kint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Rosiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Vogelaers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Colardyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700083600_ref016","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.1.164"},{"key":"S0195941700083600_ref010","doi-asserted-by":"publisher","DOI":"10.2307\/30148490"},{"key":"S0195941700083600_ref026","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.5.1615"},{"key":"S0195941700083600_ref006","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1962.03620240029006"},{"key":"S0195941700083600_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01248-2"},{"key":"S0195941700083600_ref022","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.4.1208"},{"key":"S0195941700083600_ref020","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2002.1329"},{"key":"S0195941700083600_ref002","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199908000-00002"},{"key":"S0195941700083600_ref023","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510440058033"},{"key":"S0195941700083600_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.5.866"},{"key":"S0195941700083600_ref005","doi-asserted-by":"publisher","DOI":"10.1086\/340616"},{"key":"S0195941700083600_ref003","doi-asserted-by":"publisher","DOI":"10.1080\/17843286.2000.11754307"},{"key":"S0195941700083600_ref004","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530080055041"},{"key":"S0195941700083600_ref014","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.3.9808145"},{"key":"S0195941700083600_ref024","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.1.146"},{"key":"S0195941700083600_ref011","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/10.6.1118"},{"key":"S0195941700083600_ref007","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1968.03640050028006"},{"key":"S0195941700083600_ref013","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198510000-00009"},{"key":"S0195941700083600_ref015","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.3.9911093"},{"key":"S0195941700083600_ref001","doi-asserted-by":"publisher","DOI":"10.3109\/00365549509019018"},{"key":"S0195941700083600_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90341-T"},{"key":"S0195941700083600_ref025","doi-asserted-by":"publisher","DOI":"10.1007\/BF01709471"},{"key":"S0195941700083600_ref021","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10096-002-0746-9","article-title":"Clinical impact of nosocomial Klebsiella bacteremia in critically ill patients","volume":"21","author":"Blot","year":"2002","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"S0195941700083600_ref019","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1648-8"},{"key":"S0195941700083600_ref012","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/17.1.225"},{"key":"S0195941700083600_ref018","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.19.2229"}],"container-title":["Infection Control &amp; 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