{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:25:53Z","timestamp":1771457153028,"version":"3.50.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":4325,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0195941700085325_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To determine whether disinfection protocols currently used for gastroscopes are effective against cultures of<jats:italic>Tropheryma whipplei<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700085325_abs2\"><jats:title>Design:<\/jats:title><jats:p>The bactericidal activity of 2% glutaraldehyde and two peracetic acids on the Twist-Marseille strain of<jats:italic>T. whipplei<\/jats:italic>grown in cell monolayers was determined.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700085325_abs3\"><jats:title>Patients:<\/jats:title><jats:p>Two patients who were diagnosed as having Whipple's disease 3 years after they had had intestinal biopsies.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700085325_abs4\"><jats:title>Results:<\/jats:title><jats:p>The disinfectants reduced bacteria by approximately 2 log<jats:sub>10<\/jats:sub>to 3 log<jats:sub>10<\/jats:sub>after 5 to 60 minutes of contact.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700085325_abs5\"><jats:title>Conclusion:<\/jats:title><jats:p>The bactericidal activity of a disinfectant is usually considered significant if it causes a 5 log<jats:sub>10<\/jats:sub>or greater reduction in viable bacterial titers. Disinfecting gastroscopes with<jats:italic>2%<\/jats:italic>glutaraldehyde or peracetic acids for 20 minutes may be insufficient to prevent transmission of<jats:italic>T. whipplei<\/jats:italic>on the instruments or stop false-positive results on polymerase chain reaction.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502188","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T19:01:22Z","timestamp":1141326082000},"page":"191-194","source":"Crossref","is-referenced-by-count":20,"title":["Can Whipple's Disease Be Transmitted by Gastroscopes?"],"prefix":"10.1017","volume":"24","author":[{"given":"Bernard La","family":"Scola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marc","family":"Rolain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Maurin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700085325_ref021","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2672.2001.01341.x"},{"key":"S0195941700085325_ref013","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1128\/JCM.32.4.1123-1126.1994","article-title":"Importance of fiberoptic endoscope cleaning procedure for detection of Helicobacter pylori in gastric biopsy specimens by PCR","volume":"32","author":"Roosendaal","year":"1994","journal-title":"J Clin Microbiol"},{"key":"S0195941700085325_ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CDLI.8.1.1-8.2001","article-title":"Whipple's disease","volume":"8","author":"Fenollar","year":"2001","journal-title":"Clin Diagn Lab Immunol"},{"key":"S0195941700085325_ref016","first-page":"913","volume-title":"Hospital Epidemiology and Infection Control","author":"Rutala","year":"1996"},{"key":"S0195941700085325_ref014","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-2-199301150-00008"},{"key":"S0195941700085325_ref007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420903"},{"key":"S0195941700085325_ref012","doi-asserted-by":"publisher","DOI":"10.1309\/8YGR-FE7L-39LL-L37C"},{"key":"S0195941700085325_ref009","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1128\/AEM.64.2.760-762.1998","article-title":"Environmental occurrence of the Whipple's disease bacterium (Tropheryma whippelii)","volume":"64","author":"Maiwald","year":"1998","journal-title":"Appl Environ Microbiol"},{"key":"S0195941700085325_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90545-Z"},{"key":"S0195941700085325_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90323-1"},{"key":"S0195941700085325_ref001","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-51-4-1471"},{"key":"S0195941700085325_ref010","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1128\/JCM.28.10.2234-2239.1990","article-title":"Efficacies of selected disinfectants against Mycobacterium tuberculosis","volume":"28","author":"Best","year":"1990","journal-title":"J Clin Microbiol"},{"key":"S0195941700085325_ref018","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-2-200101160-00011"},{"key":"S0195941700085325_ref004","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1086\/318512","article-title":"Whipple's disease and Tropheryma whippelii: secrets slowly revealed","volume":"32","author":"Maiwald","year":"2001","journal-title":"Clin Infect Dis"},{"key":"S0195941700085325_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90074-L"},{"key":"S0195941700085325_ref008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.8.1039"},{"key":"S0195941700085325_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(05)80232-9"},{"key":"S0195941700085325_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01776-6"},{"key":"S0195941700085325_ref002","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.10.750"},{"key":"S0195941700085325_ref011","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.5.1097"},{"key":"S0195941700085325_ref006","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199207303270501","article-title":"Identification of the uncultured bacillus of Whipple's disease","volume":"327","author":"Reiman","year":"1992","journal-title":"N Engl J Med"}],"container-title":["Infection Control &amp; 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