{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:56:53Z","timestamp":1774601813154,"version":"3.50.1"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":4264,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0195941700083478_abs1\"><jats:title>Background:<\/jats:title><jats:p>Patients with penicillin allergy admitted to the intensive care unit (ICU) frequently receive non-beta-lactam antimicrobials for the treatment of infection. The use of these antimicrobials, more commonly vancomycin and fluoroquinolones, is associated with the emergence of multidrug-resistant infections. The penicillin skin test (PST) can help detect patients at risk of developing an immediate allergic reaction to penicillin and those patients with a negative PST may be able to use a penicillin antibiotic safely.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083478_abs2\"><jats:title>Methods:<\/jats:title><jats:p>We determined the incidence of true penicillin allergy, the percentage of patients changed to a beta-lactam antimicrobial when the test was negative, the safety of the test, and the safety of administration of beta-lactam antimicrobials in patients with a negative test. Skin testing was performed using standard methodology.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083478_abs3\"><jats:title>Results:<\/jats:title><jats:p>One hundred patients admitted to 4 ICUs were prospectively studied; 58 of them were male. The mean age was 63 years. Ninety-six patients had the PST: one was positive (1.04%), 10 (10.4%) were nondiagnostic, and 85 (88.5%) were negative. Of the 38 patients who received antimicrobials for therapeutic reasons, 31(81.5%) had the antibiotic changed to a beta-lactam antimicrobial after a negative reading versus 7 patients of the 57 (12%) who had received a prophylactic antimicrobial (<jats:italic>P<\/jats:italic> &lt; .001). No adverse effects were reported after the PST or after antimicrobial administration.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700083478_abs4\"><jats:title>Conclusions:<\/jats:title><jats:p>The PST is a safe, reliable, and effective strategy to reduce the use of non-beta-lactam antimicrobials in patients who are labeled as penicillin allergic and admitted to the ICU.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502212","type":"journal-article","created":{"date-parts":[[2006,3,10]],"date-time":"2006-03-10T22:45:05Z","timestamp":1142030705000},"page":"347-350","source":"Crossref","is-referenced-by-count":57,"title":["A Prospective Observational Study of the Effect of Penicillin Skin Testing on Antibiotic Use in the Intensive Care Unit"],"prefix":"10.1017","volume":"24","author":[{"given":"Mercedes E.","family":"Arroliga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Radojicic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc J.","family":"Popovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Allen","family":"Bashour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alton L.","family":"Melton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro C.","family":"Arroliga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700083478_ref005","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.suppl_1.24S"},{"key":"S0195941700083478_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62466-0"},{"key":"S0195941700083478_ref011","doi-asserted-by":"publisher","DOI":"10.1086\/320752"},{"key":"S0195941700083478_ref012","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400170020005"},{"key":"S0195941700083478_ref008","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200104001-00011"},{"key":"S0195941700083478_ref003","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.4.1106"},{"key":"S0195941700083478_ref006","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-3-200108070-00009"},{"key":"S0195941700083478_ref014","doi-asserted-by":"publisher","DOI":"10.4065\/75.9.902"},{"key":"S0195941700083478_ref007","doi-asserted-by":"publisher","DOI":"10.1378\/chest.119.2_suppl.405S"},{"key":"S0195941700083478_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62546-X"},{"key":"S0195941700083478_ref018","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-3-199808010-00003"},{"key":"S0195941700083478_ref013","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00190-4"},{"key":"S0195941700083478_ref009","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S1081-1206(10)62890-6","article-title":"Disease management of drug hypersensitivity: a practice parameter","volume":"83","author":"Bernstein","year":"1999","journal-title":"Ann Allergy Asthma Immunol"},{"key":"S0195941700083478_ref017","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.5.1378"},{"key":"S0195941700083478_ref001","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2498"},{"key":"S0195941700083478_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62782-2"},{"key":"S0195941700083478_ref002","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.18.2819"},{"key":"S0195941700083478_ref010","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.1990.11704550"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700083478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T23:13:42Z","timestamp":1557184422000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700083478\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["S0195941700083478"],"URL":"https:\/\/doi.org\/10.1086\/502212","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}