{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:17:10Z","timestamp":1766269030766},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":4233,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0195941700085441_abs1\"><jats:title>Objectives:<\/jats:title><jats:p>To describe a longitudinal profile of resistance to beta-lactam antimicrobials among isolates of <jats:italic>Staphylococcus aureus<\/jats:italic> at a large university teaching hospital and to evaluate the impact of the methicillin resistance phenotype on resistance trends for non-beta-lactam antimicrobials.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700085441_abs2\"><jats:title>Design:<\/jats:title><jats:p>Retrospective evaluation of antimicrobial susceptibility data for all 17,287 S. <jats:italic>aureus<\/jats:italic> isolates obtained from January 1986 through December 2000.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700085441_abs3\"><jats:title>Setting:<\/jats:title><jats:p>The University of Chicago Hospitals, a family of tertiary-care, university-affiliated hospitals in Chicago, Illinois, consisting of 547 adult and pediatric beds.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700085441_abs4\"><jats:title>Results:<\/jats:title><jats:p>The annual rate of resistance to methicillin increased from 13% in 1986 to 28% in 2000 (<jats:italic>P<\/jats:italic> &lt; .001) and has not plateaued. For each non-beta-lactam antimicrobial tested, the annual rates of resistance were far higher among methicillinresistant <jats:italic>S. aureus<\/jats:italic> (MRSA) isolates than among methicillin-susceptible S. <jats:italic>aureus<\/jats:italic> (MSSA) isolates. The annual rates of resistance to the macrolide, lincosamide, and streptogramin (MLS) antimicrobials erythromycin and clindamycin increased among MSSA isolates (<jats:italic>P<\/jats:italic> &lt; .01), but remained lower than 20%. Resistance to the MLS antimicrobials was higher among MRSA isolates (higher than 60%), but the annual rate decreased significantly during the study (<jats:italic>P<\/jats:italic> &lt; .01).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700085441_abs5\"><jats:title>Conclusion:<\/jats:title><jats:p>The prevalence of methicillin resistance among S. <jats:italic>aureus<\/jats:italic> isolates has continued to increase; resistance to non-beta-lactam antimicrobials is far more common among MRSA isolates. Recent decreases in the proportion of MRSA isolates resistant to non-beta-lactam antimicrobials suggest important changes in the epidemiology of this pathogen.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502222","type":"journal-article","created":{"date-parts":[[2006,3,13]],"date-time":"2006-03-13T10:42:36Z","timestamp":1142246556000},"page":"403-408","source":"Crossref","is-referenced-by-count":35,"title":["Antimicrobial Resistance in <i>Staphylococcus aureus<\/i> at the University of Chicago Hospitals: A 15-Year Longitudinal Assessment in a Large University-Based Hospital"],"prefix":"10.1017","volume":"24","author":[{"given":"John B.","family":"Seal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy 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