{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:12:56Z","timestamp":1780103576600,"version":"3.54.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":3837,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0195941700077249_abs1\"><jats:title>Objectives:<\/jats:title><jats:p>To evaluate the immune status of healthcare workers (HCWs) against measles, rubella, mumps, and varicella in Japan, and to promote an adequate vaccination program among HCWs.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700077249_abs2\"><jats:title>Setting:<\/jats:title><jats:p>University of Tokyo Hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700077249_abs3\"><jats:title>Participants:<\/jats:title><jats:p>Eight hundred seventy-seven HCWs.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700077249_abs4\"><jats:title>Design:<\/jats:title><jats:p>Serologic screening for measles, rubella, mumps, and varicella was performed on HCWs. Antibodies against measles, rubella, and mumps were detected using hemagglutination inhibition (HI) assay ($4.20 per test). If serum was negative by HI assay, enzyme-linked immunosorbent assay (EIA) was performed ($12.60 per test). Anti-varicella antibodies were detected by EIA only.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700077249_abs5\"><jats:title>Results:<\/jats:title><jats:p>Among tested HCWs, 98.5%, 90.4%, 85.8%, and 97.2% had immunity to measles, rubella, mumps, and varicella, respectively. All those born before 1970 were seropositive for measles. However, individuals susceptible to rubella, mumps, and varicella were present in all age groups. The sensitivities and negative predictive values of HI assay compared with EIA were 86.6% and 11.3% for measles, 99.1% and 92.2% for rubella, and 47.8% and 24.1% for mumps, respectively. For measles and mumps, prevaccination screening by HI assay in combination with EIA led to significant savings compared with EIA only. In contrast, it was estimated that prevaccination screening using only HI assay would be more economical for rubella.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700077249_abs6\"><jats:title>Conclusions:<\/jats:title><jats:p>Aggressive screening and vaccination of susceptible HCWs was essential regardless of age. Prevaccination serologic screening using a combination of HI assay and EIA was more economical for measles and mumps.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502444","type":"journal-article","created":{"date-parts":[[2006,4,14]],"date-time":"2006-04-14T17:41:13Z","timestamp":1145036473000},"page":"591-594","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence of Measles, Rubella, Mumps, and Varicella Antibodies Among Healthcare Workers in Japan"],"prefix":"10.1017","volume":"25","author":[{"given":"Shuji","family":"Hatakeyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoji","family":"Moriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Itoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Nukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshizumi","family":"Shintani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Morisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700077249_ref014","first-page":"429","article-title":"Measles: progress towards global control and regional elimination, 1998-1999","volume":"74","year":"1999","journal-title":"Wkly Epidemiol Rec"},{"key":"S0195941700077249_ref017","doi-asserted-by":"publisher","DOI":"10.1053\/jhin.2002.1222"},{"key":"S0195941700077249_ref002","first-page":"273","article-title":"Infectious Diseases Surveillance Center of the National Institute of Infectious Diseases. Measles, Japan 1999-2001 [in Japanese]","volume":"22","year":"2001","journal-title":"Infectious Agents Surveillance Report"},{"key":"S0195941700077249_ref003","first-page":"55","article-title":"Infectious Diseases Surveillance Center of the National Institute of Infectious Diseases. Rubella vaccine coverage in Japan [in Japanese]","volume":"24","year":"2003","journal-title":"Infectious Agents Surveillance Report"},{"key":"S0195941700077249_ref016","first-page":"664","article-title":"National, state, and urban area vaccination coverage levels among children aged 19-35 months: United States, 2001","volume":"51","year":"2002","journal-title":"MMWR"},{"key":"S0195941700077249_ref018","doi-asserted-by":"crossref","first-page":"478","DOI":"10.5694\/j.1326-5377.1994.tb138311.x","article-title":"Cost effectiveness of prevaccination screening of health care workers for immunity to measles, rubella and mumps","volume":"160","author":"Ferson","year":"1994","journal-title":"Med J Aust"},{"key":"S0195941700077249_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92311-X"},{"key":"S0195941700077249_ref010","first-page":"1","article-title":"Prevention of varicella: update recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"45","year":"1996","journal-title":"MMWR Recomm Rep"},{"key":"S0195941700077249_ref008","first-page":"1","article-title":"Immunization of healthcare workers: recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Hospital Infection Control Practices Advisory Committee (HICPAC)","volume":"46","year":"1997","journal-title":"MMWR Recomm Rep"},{"key":"S0195941700077249_ref007","doi-asserted-by":"publisher","DOI":"10.1007\/s10156-002-0206-6"},{"key":"S0195941700077249_ref001","first-page":"101","article-title":"Development of vaccination policy in Japan: current issues and policy directions","volume":"55","author":"Nakatani","year":"2002","journal-title":"Jpn J Infect Dis"},{"key":"S0195941700077249_ref009","first-page":"1","article-title":"Measles, mumps, and rubella-vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"47","year":"1998","journal-title":"MMWR Recomm Rep"},{"key":"S0195941700077249_ref011","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1128\/JCM.22.2.296-298.1985","article-title":"Comparison of measles antihemolysin test, enzyme-linked immunosorbent assay, and hemagglutination inhibition test with neutralization test for determination of immune status","volume":"22","author":"Neumann","year":"1985","journal-title":"J Clin Microbiol"},{"key":"S0195941700077249_ref012","first-page":"391","article-title":"Evaluation of enzyme immunosorbent rubella assays","volume":"109","author":"Skendzel","year":"1985","journal-title":"Arch Pathol Lab Med"},{"key":"S0195941700077249_ref005","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199103000-00007"},{"key":"S0195941700077249_ref021","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-12-982"},{"key":"S0195941700077249_ref020","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/163.4.876"},{"key":"S0195941700077249_ref013","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890080202"},{"key":"S0195941700077249_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02325-4"},{"key":"S0195941700077249_ref019","first-page":"275","article-title":"Infectious Diseases Surveillance Center of the National Institute of Infectious Diseases. Measles antibody prevalence and vaccine coverage in Japan, 2000: National Epidemiological Surveillance of Vaccine-Preventable Diseases [in Japanese]","volume":"22","year":"2001","journal-title":"Infectious Agents Surveillance Report"},{"key":"S0195941700077249_ref004","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199103000-00008"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700077249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T08:34:43Z","timestamp":1722242083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700077249\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0195941700077249"],"URL":"https:\/\/doi.org\/10.1086\/502444","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}