{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T01:33:24Z","timestamp":1777253604322,"version":"3.51.4"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":3775,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0195941700080152_abs1\"><jats:title>Objective:<\/jats:title><jats:p>To determine the incidence, clinical characteristics, and risk factors associated with the first culture-proven episode of sepsis among neonates in a neonatal intensive care unit (NICU).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080152_abs2\"><jats:title>Setting:<\/jats:title><jats:p>Level-II NICU in the United Kingdom.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080152_abs3\"><jats:title>Patients:<\/jats:title><jats:p>Neonates with their first culture-proven sepsis between January 1, 1996, and December 31, 2000.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080152_abs4\"><jats:title>Methods:<\/jats:title><jats:p>Demographic data were obtained from the NICU database and chart review. Sepsis was considered early (EOS; &lt; 72 hours old) or late (LOS; &gt; 72 hours old). Data were also collected on potential risk factors.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080152_abs5\"><jats:title>Results:<\/jats:title><jats:p>Among 14,767 live births, 1,612 (11%) neonates were admitted to the NICU during the study period. Nine hundred eight were screened for sepsis. One hundred twenty-four had at least one positive culture (overall sepsis rate of 8.4 per 1,000 live births [1%] or 77 per 1,000 NICU admissions). Twenty-four neonates had EOS and 100 had LOS. Coagulase-negative staphylococci (CoNS) and group B <jats:italic>Streptococcus<\/jats:italic> were the most frequent organisms causing EOS, whereas CoNS and <jats:italic>Escherichia coli<\/jats:italic> most frequently caused LOS. Birth before 30 weeks' gestation and birth weight less than 1,500 g were risk factors for sepsis. Resuscitation at birth was the leading risk factor for EOS and respiratory support prior to sepsis, presence of a central or peripheral catheter, and total parenteral nutrition were leading risk factors for LOS.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700080152_abs6\"><jats:title>Conclusions:<\/jats:title><jats:p>A strong inverse relationship existed between gestational age of 30 weeks or younger and birth weight of 1,500 g or less and LOS. Resuscitation and indwelling intravenous catheters were also risk factors.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502473","type":"journal-article","created":{"date-parts":[[2006,4,14]],"date-time":"2006-04-14T17:50:53Z","timestamp":1145037053000},"page":"759-764","source":"Crossref","is-referenced-by-count":34,"title":["Pattern of Culture-Proven Neonatal Sepsis in a District General Hospital in the United Kingdom"],"prefix":"10.1017","volume":"25","author":[{"given":"Khalid N.","family":"Haque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Ajaz","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Kerry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gretta","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700080152_ref020","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1996.tb00967.x"},{"key":"S0195941700080152_ref019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.1995.tb00843.x"},{"key":"S0195941700080152_ref009","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"S0195941700080152_ref017","unstructured":"Brocklehurst P . 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