{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:53:39Z","timestamp":1773827619419,"version":"3.50.1"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"unspecified","delay-in-days":4158,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X00197624_abs1\"><jats:title><jats:bold>Objective:<\/jats:bold><\/jats:title><jats:p>Comorbid conditions have complicated previous analyses of the consequences of methicillin resistance for costs and outcomes of<jats:italic>Staphylococcus aureus<\/jats:italic>bacteremia. We compared costs and outcomes of methicillin resistance in patients with<jats:italic>S. aureus<\/jats:italic>bacteremia and a single chronic condition.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00197624_abs2\"><jats:title><jats:bold>Design, Setting, and Patients:<\/jats:bold><\/jats:title><jats:p>We conducted a prospective cohort study of hemodialysis-dependent patients with end-stage renal disease and<jats:italic>S. aureus<\/jats:italic>bacteremia hospitalized between July 1996 and August 2001. We used propensity scores to reduce bias when comparing patients with methicillin-resistant (MRSA) and methicillin-susceptible (MSSA)<jats:italic>S. aureus<\/jats:italic>bacteremia. Outcome measures were resource use, direct medical costs, and clinical outcomes at 12 weeks after initial hospitalization.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00197624_abs3\"><jats:title><jats:bold>Results:<\/jats:bold><\/jats:title><jats:p>Fifty-four patients (37.8%) had MRSA and 89 patients (62.2%) had MSSA. Compared with patients with MSSA bacteremia, patients with MRSA bacteremia were more likely to have acquired the infection while hospitalized for another condition (27.8% vs 12.4%;<jats:italic>P<\/jats:italic>= .02). To attribute all inpatient costs to<jats:italic>S. aureus<\/jats:italic>bacteremia, we limited the analysis to 105 patients admitted for suspected<jats:italic>S. aureus<\/jats:italic>bacteremia from a community setting. Adjusted costs were higher for MRSA bacteremia for the initial hospitalization ($21,251 vs $13,978;<jats:italic>P<\/jats:italic>= .012) and after 12 weeks ($25,518 vs $17,354;<jats:italic>P<\/jats:italic>= .015). At 12 weeks, patients with MRSA bacteremia were more likely to die (adjusted odds ratio, 5.4; 95% confidence interval, 1.5 to 18.7) than were patients with MSSA bacteremia.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00197624_abs4\"><jats:title><jats:bold>Conclusions:<\/jats:bold><\/jats:title><jats:p>Community-dwelling, hemodialysis-dependent patients hospitalized with MRSA bacteremia face a higher mortality risk, longer hospital stays, and higher inpatient costs than do patients with MSSA bacteremia.<\/jats:p><\/jats:sec>","DOI":"10.1086\/502523","type":"journal-article","created":{"date-parts":[[2006,4,14]],"date-time":"2006-04-14T20:10:46Z","timestamp":1145045446000},"page":"175-183","source":"Crossref","is-referenced-by-count":157,"title":["Costs and Outcomes Among Hemodialysis-Dependent Patients With Methicillin-Resistant or Methicillin-Susceptible<i>Staphylococcus aureus<\/i>Bacteremia"],"prefix":"10.1017","volume":"26","author":[{"given":"Shelby D.","family":"Reed","sequence":"first","affiliation":[]},{"given":"Jo\u00eblle Y.","family":"Friedman","sequence":"additional","affiliation":[]},{"given":"John J.","family":"Engemann","sequence":"additional","affiliation":[]},{"given":"Robert I.","family":"Griffiths","sequence":"additional","affiliation":[]},{"given":"Kevin J.","family":"Anstrom","sequence":"additional","affiliation":[]},{"given":"Keith S.","family":"Kaye","sequence":"additional","affiliation":[]},{"given":"Martin E.","family":"Stryjewski","sequence":"additional","affiliation":[]},{"given":"Lynda A.","family":"Szczech","sequence":"additional","affiliation":[]},{"given":"L. Barth","family":"Reller","sequence":"additional","affiliation":[]},{"given":"G. Ralph","family":"Corey","sequence":"additional","affiliation":[]},{"given":"Kevin A.","family":"Schulman","sequence":"additional","affiliation":[]},{"suffix":"Jr","given":"Vance G.","family":"Fowler","sequence":"additional","affiliation":[]}],"member":"56","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"S0899823X00197624_ref032","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-8_Part_2-199710151-00064"},{"key":"S0899823X00197624_ref014","doi-asserted-by":"publisher","DOI":"10.1086\/501707"},{"key":"S0899823X00197624_ref005","unstructured":"Cosgrove SE , Qi Y , Kaye KS , Harbarth S , Karchmer AW , Carmeli Y . The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charge. Presented at the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy; December 16-19, 2001; Chicago, IL. 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