{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:32:51Z","timestamp":1791264771720,"version":"4.1.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"unspecified","delay-in-days":4038,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X00198447_abs1\"><jats:title>Background and Objective:<\/jats:title><jats:p>Coagulase-negative staphylococci are both an important cause of nosocomial bloodstream infections and the most common contaminants of blood cultures. Judging the clinical significance of coagulase-negative staphylococci is vital but often difficult and can have a profound impact on an institution's bloodstream infection rates. Our objective was to develop an algorithm to assist in determining the clinical significance of coagulase-negative staphylococci.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00198447_abs2\"><jats:title>Design:<\/jats:title><jats:p>A single experienced reviewer examined the medical records of 960 consecutive patients with positive blood cultures in a tertiary-care referral teaching hospital. Four hundred five of the cultures contained coagulase-negative staphylococci. A determination of clinical significance was made and the performances of various published algorithms that contained readily available clinical and laboratory data were compared.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00198447_abs3\"><jats:title>Results:<\/jats:title><jats:p>Eighty-nine (22%) of the episodes were considered significant, whereas 316 were contaminants. Patients with bacteremia were significantly more likely to be neutropenic and exhibit signs of sepsis syndrome. The algorithm with the best combined sensitivity (62%) and specificity (91%) for determining the clinical significance of coagulase-negative staphylococci was defined as at least two blood cultures positive for coagulase-negative staphylococci within 5 days, or one positive blood culture plus clinical evidence of infection, which includes abnormal white blood cell count and temperature or blood pressure.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00198447_abs4\"><jats:title>Conclusion:<\/jats:title><jats:p>Use of this algorithm could potentially reduce misclassification of nosocomial bloodstream infections and inappropriate use of vancomycin for positive blood cultures likely to represent contamination (<jats:italic>Infect Control Hosp Epidemiol<\/jats:italic>2005;26:559-566).<\/jats:p><\/jats:sec>","DOI":"10.1086\/502584","type":"journal-article","created":{"date-parts":[[2006,4,14]],"date-time":"2006-04-14T20:33:48Z","timestamp":1145046828000},"page":"559-566","source":"Crossref","is-referenced-by-count":152,"title":["Determining the Clinical Significance of Coagulase-Negative Staphylococci Isolated From Blood Cultures"],"prefix":"10.1017","volume":"26","author":[{"given":"Susan E.","family":"Beekmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Diekema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary V.","family":"Doern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"S0899823X00198447_ref022","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.1.495-497.2003"},{"key":"S0899823X00198447_ref010","doi-asserted-by":"publisher","DOI":"10.1086\/501747"},{"key":"S0899823X00198447_ref006","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1128\/JCM.36.7.1923-1926.1998","article-title":"Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients","volume":"36","author":"Souvenir","year":"1998","journal-title":"J Clin Microbiol"},{"key":"S0899823X00198447_ref020","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2002.118406"},{"key":"S0899823X00198447_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.1.14"},{"key":"S0899823X00198447_ref008","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.7.2437-2444.2002"},{"key":"S0899823X00198447_ref005","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460030071031"},{"key":"S0899823X00198447_ref023","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.3119-3125.2003"},{"key":"S0899823X00198447_ref003","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.8.3655-3660.2003"},{"key":"S0899823X00198447_ref002","doi-asserted-by":"publisher","DOI":"10.1086\/520192"},{"key":"S0899823X00198447_ref025","doi-asserted-by":"publisher","DOI":"10.1086\/320001"},{"key":"S0899823X00198447_ref024","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.9.3279-3281.2001"},{"key":"S0899823X00198447_ref019","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1972.03650010072013"},{"key":"S0899823X00198447_ref001","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/24.4.584"},{"key":"S0899823X00198447_ref014","first-page":"1","article-title":"Guidelines for the prevention of intravascular catheter-related infections","volume":"51","year":"2002","journal-title":"MMWR"},{"key":"S0899823X00198447_ref018","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-1-9"},{"key":"S0899823X00198447_ref016","doi-asserted-by":"publisher","DOI":"10.1017\/S0195941700063591"},{"key":"S0899823X00198447_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(98)90172-4"},{"key":"S0899823X00198447_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.3.520"},{"key":"S0899823X00198447_ref007","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.6.2275-2278.2003"},{"key":"S0899823X00198447_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00596-9"},{"key":"S0899823X00198447_ref009","doi-asserted-by":"publisher","DOI":"10.1086\/322673"},{"key":"S0899823X00198447_ref004","doi-asserted-by":"publisher","DOI":"10.2307\/30141785"},{"key":"S0899823X00198447_ref021","unstructured":"Beekmann SE , Diekema DJ , Munson EL , Doern GV . Specificity and positive predictive value of the NNIS definition of laboratory-confirmed bloodstream infection with common skin contaminants. Presented at the 12th Annual Meeting of the Society for Healthcare Epidemiology of America; April 6-9, 2002; Salt Lake City, UT."},{"key":"S0899823X00198447_ref015","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1128\/JCM.33.4.816-820.1995","article-title":"Coagulase-negative staphylococci in multiple blood cultures: strain relatedness and determinants of same-strain bacteremia","volume":"33","author":"Khatib","year":"1994","journal-title":"J Clin Microbiol"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X00198447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T20:47:05Z","timestamp":1586810825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X00198447\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["S0899823X00198447"],"URL":"https:\/\/doi.org\/10.1086\/502584","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,6]]}}}