{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T07:57:58Z","timestamp":1722067078813},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"unspecified","delay-in-days":4008,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0899823X00198605_abs1\"><jats:title>Background and Objective:<\/jats:title><jats:p>Nosocomial infections caused by methicillin-resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(MRSA) are increasing. Only a few studies of MRSA infective endocarditis have been conducted, and none have reported its risk factors. We sought to determine the host-related risk factors for infective endocarditis in patients with nosocomial MRSA bacteremia.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00198605_abs2\"><jats:title>Setting:<\/jats:title><jats:p>A 2,000-bed, university-affiliated, tertiary-care hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00198605_abs3\"><jats:title>Patients:<\/jats:title><jats:p>Thirty-one patients with nosocomial MRSA infective endocarditis between October 1996 and May 2003.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00198605_abs4\"><jats:title>Design:<\/jats:title><jats:p>A retrospective chart review was conducted. Data were compared with those from a control group of patients with nosocomial MRSA bacteremia. Logistic regression was used to identify independent risk factors for nosocomial infective endocarditis.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00198605_abs5\"><jats:title>Results:<\/jats:title><jats:p>Compared with patients who had nosocomial MRSA bacteremia and no infective endocarditis, patients who had infective endocarditis had a higher incidence of chronic liver disease and a lower incidence of immunodeficiency. The risk of developing infective endocarditis was approximately 10% for patients with nosocomial MRSA bacteremia.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00198605_abs6\"><jats:title>Conclusion:<\/jats:title><jats:p>Patients with MRSA bacteremia and underlying chronic liver disease were prone to infective endocarditis. 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