{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:33:41Z","timestamp":1790048021459,"version":"4.0.1"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"unspecified","delay-in-days":3704,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec id=\"S0899823X00195212_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To examine the hypothesis that results of the QuantiFERON-TB Gold assay (QFT-G), a whole-blood test for detection of tuberculosis infection, are more significantly related to known risk factors for tuberculosis infection in healthcare workers (HCWs) who have received bacille Calmette-Guerin vaccine than are results of the Mantoux tuberculin skin test (TST).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00195212_abs2\"><jats:title>Design.<\/jats:title><jats:p>All HCWs (approximately 510) from a 370-bed general hospital in Tokyo where patients with and patients without tuberculosis are treated were invited to participate in the study. All study participants completed a questionnaire about their <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection risk factors as HCWs at the general hospital. They were then tested for LTBI by means of the QFT-G, followed by the TST. Statistical analyses were performed to compare results of each test with <jats:italic>M. tuberculosis<\/jats:italic> infection risk factors (age, length of employment in the healthcare industry, history of working with tuberculosis-positive patients in a tuberculosis ward or in the outpatient department of the hospital's tuberculosis clinic for more than 1 year, chest radiograph evidence of healed tuberculosis, history of performing bronchoscope procedures, and job classification), and for TST-positive HCWs, to compare the QFT-G result with the TST induration diameter.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00195212_abs3\"><jats:title>Results.<\/jats:title><jats:p>A total of 332 HCWs (95% of whom had been vaccinated with BCG) participated in the study, and 33 had positive QFT-G results, suggesting a prevalence of LTBI of 9.9%. Of 304 HCWs who underwent TST, 283 (93.1%) had an induration diameter of 10 mm or more. Multiple logistic regression analysis revealed that positive QFT-G results were significantly associated with age and with a history of working in a tuberculosis ward or an outpatient department of a tuberculosis clinic. TST results were not correlated with any of the tuberculosis infection risk factors we evaluated.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00195212_abs4\"><jats:title>Conclusions.<\/jats:title><jats:p>Positive QFT-G results were closely associated with the presence of risk factors for LTBI in a hospital setting, suggesting that the QFT-G can detect LTBI in a population composed predominately of BCG vaccinees. Because most HCWs worldwide have been vaccinated with BCG, the QFT-G offers a significant improvement over the TST in tuberculosis screening programs and minimizes un-warranted use of tuberculosis prophylaxis.<\/jats:p><\/jats:sec>","DOI":"10.1086\/504358","type":"journal-article","created":{"date-parts":[[2006,5,2]],"date-time":"2006-05-02T21:02:01Z","timestamp":1146603721000},"page":"442-448","source":"Crossref","is-referenced-by-count":102,"title":["Screening for Tuberculosis Infection Using Whole-Blood Interferon-\u03b3 and Mantoux Testing Among Japanese Healthcare Workers"],"prefix":"10.1017","volume":"27","author":[{"given":"Nobuyuki","family":"Harada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutsuki","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazue","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukie","family":"Sekiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Rothel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"S0899823X00195212_ref024","doi-asserted-by":"publisher","DOI":"10.3201\/eid0606.000602"},{"key":"S0899823X00195212_ref002","first-page":"819","article-title":"Tuberculosis risk of female nurses based on the Tuberculosis Surveillance Data [in Japanese]","volume":"74","author":"Yamauchi","year":"1999","journal-title":"Kekkaku"},{"key":"S0899823X00195212_ref007","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-77-3-377"},{"key":"S0899823X00195212_ref020","first-page":"637","article-title":"Usefulness of a novel diagnostic method of tuberculosis infection, QuantiFERON-TB-2G, in an outbreak of tuberculosis [in Japanese, with an abstract and tables and figures in English]","volume":"79","author":"Harada","year":"2004","journal-title":"Kekkaku"},{"key":"S0899823X00195212_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90060-5"},{"key":"S0899823X00195212_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.6.968"},{"key":"S0899823X00195212_ref022","first-page":"563","article-title":"Further studies on the potency of purified protein derivatives of tuberculin (PPDs). 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