{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:58:33Z","timestamp":1790974713499,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":2544,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA78224"],"award-info":[{"award-number":["CA78224"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA51001"],"award-info":[{"award-number":["CA51001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM61393"],"award-info":[{"award-number":["GM61393"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA36401"],"award-info":[{"award-number":["CA36401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA21765"],"award-info":[{"award-number":["CA21765"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01"],"award-info":[{"award-number":["U01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["CA78224"],"award-info":[{"award-number":["CA78224"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["CA51001"],"award-info":[{"award-number":["CA51001"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["GM61393"],"award-info":[{"award-number":["GM61393"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["CA36401"],"award-info":[{"award-number":["CA36401"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["CA21765"],"award-info":[{"award-number":["CA21765"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","award":["U01"],"award-info":[{"award-number":["U01"]}],"id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["CA78224"],"award-info":[{"award-number":["CA78224"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["CA51001"],"award-info":[{"award-number":["CA51001"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["GM61393"],"award-info":[{"award-number":["GM61393"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["CA36401"],"award-info":[{"award-number":["CA36401"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["CA21765"],"award-info":[{"award-number":["CA21765"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["U01"],"award-info":[{"award-number":["U01"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1086\/505645","type":"journal-article","created":{"date-parts":[[2006,7,5]],"date-time":"2006-07-05T20:43:05Z","timestamp":1152132185000},"page":"264-274","source":"Crossref","is-referenced-by-count":30,"title":["Epigenetic Regulation of Human \u03b3-Glutamyl Hydrolase Activity in Acute Lymphoblastic Leukemia Cells"],"prefix":"10.1016","volume":"79","author":[{"given":"Qing","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine R.","family":"Crews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul C.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hon","family":"Pui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary V.","family":"Relling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/505645_bib4","doi-asserted-by":"crossref","first-page":"7431","DOI":"10.1038\/sj.onc.1206946","article-title":"Resistance to antifolates","volume":"22","author":"Zhao","year":"2003","journal-title":"Oncogene"},{"key":"10.1086\/505645_bib5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.taap.2003.12.032","article-title":"Causes of childhood leukaemia and lymphoma","volume":"199","author":"Lightfoot","year":"2004","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1086\/505645_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0163-7258(99)00063-7","article-title":"Glutamyl hydrolase: pharmacological role and enzymatic characterization","volume":"85","author":"Galivan","year":"2000","journal-title":"Pharmacol Ther"},{"key":"10.1086\/505645_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1056\/NEJMra052603","article-title":"Treatment of acute lymphoblastic leukemia","volume":"354","author":"Pui","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1086\/505645_bib8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1172\/JCI118409","article-title":"Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo: a rationale for high-dose methotrexate","volume":"97","author":"Masson","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1086\/505645_bib9","first-page":"33","article-title":"Glutamyl hydrolase: properties and pharmacologic impact","volume":"26","author":"Galivan","year":"1999","journal-title":"Semin Oncol"},{"key":"10.1086\/505645_bib10","first-page":"2423","article-title":"Methotrexate intracellular disposition in acute lymphoblastic leukemia: a mathematical model of \u03b3-glutamyl hydrolase activity","volume":"8","author":"Panetta","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1086\/505645_bib11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/01.fpc.0000114761.78957.7e","article-title":"A substrate specific functional polymorphism of human \u03b3-glutamyl hydrolase alters catalytic activity and methotrexate polyglutamate accumulation in acute lymphoblastic leukaemia cells","volume":"14","author":"Cheng","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1086\/505645_bib12","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/ng1612","article-title":"Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes","volume":"37","author":"Cheng","year":"2005","journal-title":"Nat Genet"},{"key":"10.1086\/505645_bib13","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/hmg\/11.20.2479","article-title":"Cancer epigenomics","volume":"11","author":"Plass","year":"2002","journal-title":"Hum Mol Genet"},{"key":"10.1086\/505645_bib14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/321209a0","article-title":"CpG-rich islands and the function of DNA methylation","volume":"321","author":"Bird","year":"1986","journal-title":"Nature"},{"key":"10.1086\/505645_bib15","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/nrc1507","article-title":"CpG island methylator phenotype in cancer","volume":"4","author":"Issa","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1086\/505645_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg816","article-title":"The fundamental role of epigenetic events in cancer","volume":"3","author":"Jones","year":"2002","journal-title":"Nat Rev Genet"},{"key":"10.1086\/505645_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1535-6108(02)00032-6","article-title":"Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling","volume":"1","author":"Yeoh","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1086\/505645_bib18","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1200\/JCO.2002.10.006","article-title":"Interim comparison of a continuous infusion versus a short daily infusion of cytarabine given in combination with cladribine for pediatric acute myeloid leukemia","volume":"20","author":"Crews","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1086\/505645_bib19","series-title":"ISCN 1995: an international system for human cytogenetic nomenclature","year":"1995"},{"key":"10.1086\/505645_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/ng1151","article-title":"Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells","volume":"34","author":"Cheok","year":"2003","journal-title":"Nat Genet"},{"key":"10.1086\/505645_bib21","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/bioinformatics\/18.11.1427","article-title":"MethPrimer: designing primers for methylation PCRs","volume":"18","author":"Li","year":"2002","journal-title":"Bioinformatics"},{"key":"10.1086\/505645_bib22","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1172\/JCI22477","article-title":"Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics","volume":"115","author":"Kager","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1086\/505645_bib23","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1182\/blood.V93.5.1677","article-title":"Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia","volume":"93","author":"Rots","year":"1999","journal-title":"Blood"},{"key":"10.1086\/505645_bib24","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0378-1119(99)00362-5","article-title":"Structural organization of the human \u03b3-glutamyl hydrolase gene","volume":"238","author":"Yin","year":"1999","journal-title":"Gene"},{"key":"10.1086\/505645_bib25","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJMra023001","article-title":"Acute lymphoblastic leukemia","volume":"350","author":"Pui","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1086\/505645_bib26","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.V76.1.44.44","article-title":"Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis","volume":"76","author":"Whitehead","year":"1990","journal-title":"Blood"},{"key":"10.1086\/505645_bib27","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1172\/JCI117552","article-title":"Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia","volume":"94","author":"Synold","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1086\/505645_bib28","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.leu.2402165","article-title":"The association of the TEL-AML1 chromosomal translocation with the accumulation of methotrexate polyglutamates in lymphoblasts and with ploidy in childhood B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group study","volume":"15","author":"Whitehead","year":"2001","journal-title":"Leukemia"},{"key":"10.1086\/505645_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1101\/gad.947102","article-title":"DNA methylation patterns and epigenetic memory","volume":"16","author":"Bird","year":"2002","journal-title":"Genes Dev"},{"key":"10.1086\/505645_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/35047554","article-title":"Genomic imprinting: parental influence on the genome","volume":"2","author":"Reik","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1086\/505645_bib31","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","article-title":"Targeted mutation of the DNA methyltransferase gene results in embryonic lethality","volume":"69","author":"Li","year":"1992","journal-title":"Cell"},{"issue":"Spec No 1","key":"10.1086\/505645_bib32","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1093\/hmg\/ddi113","article-title":"Cancer epigenetics","volume":"14","author":"Laird","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1086\/505645_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrc1279","article-title":"The history of cancer epigenetics","volume":"4","author":"Feinberg","year":"2004","journal-title":"Nat Rev Cancer"},{"key":"10.1086\/505645_bib34","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1056\/NEJMra023075","article-title":"Gene silencing in cancer in association with promoter hypermethylation","volume":"349","author":"Herman","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1086\/505645_bib35","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrg1655","article-title":"DNA methylation and human disease","volume":"6","author":"Robertson","year":"2005","journal-title":"Nat Rev Genet"},{"key":"10.1086\/505645_bib36","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/ng0394-236","article-title":"Purification of CpG islands using a methylated DNA binding column","volume":"6","author":"Cross","year":"1994","journal-title":"Nat Genet"},{"key":"10.1086\/505645_bib37","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/hmg\/8.3.459","article-title":"Methylation profiling of CpG islands in human breast cancer cells","volume":"8","author":"Huang","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1086\/505645_bib38","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/hmg\/10.9.903","article-title":"The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells","volume":"10","author":"Pao","year":"2001","journal-title":"Hum Mol Genet"},{"key":"10.1086\/505645_bib39","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1073\/pnas.94.6.2103","article-title":"Altered DNA methylation and genome instability: a new pathway to cancer?","volume":"94","author":"Jones","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1086\/505645_bib40","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/72785","article-title":"Aberrant CpG-island methylation has non-random and tumour-type-specific patterns","volume":"24","author":"Costello","year":"2000","journal-title":"Nat Genet"},{"key":"10.1086\/505645_bib41","doi-asserted-by":"crossref","first-page":"5619","DOI":"10.1038\/sj.onc.1208722","article-title":"Distinct CpG methylation profiles characterize different clinical groups of neuroblastic tumors","volume":"24","author":"Banelli","year":"2005","journal-title":"Oncogene"},{"key":"10.1086\/505645_bib42","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/ng1598","article-title":"Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells","volume":"37","author":"Weber","year":"2005","journal-title":"Nat Genet"},{"key":"10.1086\/505645_bib43","doi-asserted-by":"crossref","first-page":"7421","DOI":"10.1128\/MCB.14.11.7421","article-title":"Comparison of DNA methylation patterns among mouse cell lines by restriction landmark genomic scanning","volume":"14","author":"Kawai","year":"1994","journal-title":"Mol Cell Biol"},{"key":"10.1086\/505645_bib44","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.1093\/nar\/gnh057","article-title":"Attachment of oligonucleotide probes to poly carbodiimide-coated glass for microarray applications","volume":"32","author":"Kimura","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1086\/505645_bib45","doi-asserted-by":"crossref","first-page":"2952","DOI":"10.1093\/nar\/gki582","article-title":"CpG island microarray probe sequences derived from a physical library are representative of CpG islands annotated on the human genome","volume":"33","author":"Heisler","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.1086\/505645_bib46","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/371435a0","article-title":"Sp1 elements protect a CpG island from de novo methylation","volume":"371","author":"Brandeis","year":"1994","journal-title":"Nature"},{"key":"10.1086\/505645_bib47","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1093\/nar\/26.22.5163","article-title":"The primary function of a redundant Sp1 binding site in the mouse aprt gene promoter is to block epigenetic gene inactivation","volume":"26","author":"Mummaneni","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1086\/505645_bib48","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/sj.leu.2401401","article-title":"Cancer-specific region of hypermethylation identified within the HIC1 putative tumour suppressor gene in acute myeloid leukaemia","volume":"13","author":"Melki","year":"1999","journal-title":"Leukemia"},{"key":"10.1086\/505645_bib49","doi-asserted-by":"crossref","first-page":"24893","DOI":"10.1074\/jbc.M906538199","article-title":"A distinct sequence (ATAAA)n separates methylated and unmethylated domains at the 5\u2032-end of the GSTP1 CpG island","volume":"275","author":"Millar","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1086\/505645_bib50","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1126\/science.1101372","article-title":"Small interfering RNA-induced transcriptional gene silencing in human cells","volume":"305","author":"Morris","year":"2004","journal-title":"Science"},{"key":"10.1086\/505645_bib51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nature02889","article-title":"Induction of DNA methylation and gene silencing by short interfering RNAs in human cells","volume":"431","author":"Kawasaki","year":"2004","journal-title":"Nature"},{"key":"10.1086\/505645_bib52","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.4161\/cc.4.11.2160","article-title":"Cancer pharmacogenomics may require both qualitative and quantitative approaches","volume":"4","author":"Cheng","year":"2005","journal-title":"Cell Cycle"},{"key":"10.1086\/505645_bib53","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.humpath.2004.06.014","article-title":"Identification of carboxypeptidase E and \u03b3-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray","volume":"35","author":"He","year":"2004","journal-title":"Hum Pathol"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707631346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707631346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T07:19:38Z","timestamp":1616224778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707631346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0002929707631346"],"URL":"https:\/\/doi.org\/10.1086\/505645","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}