{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T17:13:42Z","timestamp":1775150022410,"version":"3.50.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"unspecified","delay-in-days":3520,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec id=\"S0899823X00196850_abs1\"><jats:title>Objectives.<\/jats:title><jats:p>To determine the predictors of 7-day mortality in older adult patients with <jats:italic>Staphylococcus aureus<\/jats:italic> bacteremia after controlling for comorbidity using the Charlson weighted index of comorbidity (WIC) and to identify the risk factors associated with bacteremia due to methicillin-resistant <jats:italic>S. aureus<\/jats:italic> (MRSA).<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00196850_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective cohort study from January 2003 until December 2004.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00196850_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Two tertiary care, university-affiliated hospitals.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00196850_abs4\"><jats:title>Methods.<\/jats:title><jats:p>One hundred thirty-five hospitalized patients with <jats:italic>S. aureus<\/jats:italic> bacteremia were included in the study. All patients who were 60 years or older and had 1 or more blood cultures positive for <jats:italic>S. aureus<\/jats:italic> were included in the study. The primary outcome was death 7 days after the onset of <jats:italic>S. aureus<\/jats:italic> bacteremia.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00196850_abs5\"><jats:title>Results.<\/jats:title><jats:p>Twenty-one patients (15.6%) died within 7 days after the onset of <jats:italic>S. aureus<\/jats:italic> bacteremia. Seventy-four patients (56.1%) had MRSA bacteremia. Multivariate analysis identified 3 independent determinants of 7-day mortality: Charlson WIC score greater than 5 (odds ratio [OR], 3.6 [95% confidence interval {CI}, 1.1-11.2]; <jats:italic>P<\/jats:italic> = .03), previous hospitalization in the past 3 months (OR, 5.0 [95% CI, 1.1-25.1]; <jats:italic>P<\/jats:italic> = .04), and altered mental status at the onset of <jats:italic>S. aureus<\/jats:italic> bacteremia (OR, 13.6 [95% CI, 2.9-64.6]; P = .001). Multivariate analysis identified .previous hospitalization in the past 3 months (OR, 2.6 [95% CI, 1.1-5.9]; <jats:italic>P<\/jats:italic> = .02), residence in a long-term care facility (OR, 4.5 [95% CI, 1.7-12.3]; <jats:italic>P<\/jats:italic> = .003), and altered mental status at the onset of <jats:italic>S. aureus<\/jats:italic> bacteremia (OR, 2.5 [95% CI, 1.5-5.6]; <jats:italic>P<\/jats:italic> = .02) to be independently associated with the presence of MRSA.<\/jats:p><\/jats:sec><jats:sec id=\"S0899823X00196850_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>The Charlson WIC is significantly associated with increased mortality of <jats:italic>S. aureus<\/jats:italic> bacteremia in older adults. Previous hospitalization in the past 3 months, residence in a long-term care facility, and altered mental status should be used as a guidance for empirical vancomycin therapy and application of infection control measures in older adults with suspected <jats:italic>S. aureus<\/jats:italic> bacteremia.<\/jats:p><\/jats:sec>","DOI":"10.1086\/507924","type":"journal-article","created":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T16:44:35Z","timestamp":1161794675000},"page":"1219-1225","source":"Crossref","is-referenced-by-count":41,"title":["<i>Staphylococcus aureus<\/i> Bacteremia in Older Adults: Predictors of 7-Day Mortality and Infection With a Methicillin-Resistant Strain"],"prefix":"10.1017","volume":"27","author":[{"given":"Mazen S.","family":"Bader","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"S0899823X00196850_ref005","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.1.25"},{"key":"S0899823X00196850_ref018","doi-asserted-by":"publisher","DOI":"10.1086\/501718"},{"key":"S0899823X00196850_ref024","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh366"},{"key":"S0899823X00196850_ref012","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03510240069035"},{"key":"S0899823X00196850_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"S0899823X00196850_ref003","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50458.x"},{"key":"S0899823X00196850_ref021","doi-asserted-by":"publisher","DOI":"10.1086\/501567"},{"key":"S0899823X00196850_ref010","doi-asserted-by":"publisher","DOI":"10.1086\/501655"},{"key":"S0899823X00196850_ref023","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200203000-00001"},{"key":"S0899823X00196850_ref009","doi-asserted-by":"publisher","DOI":"10.3201\/eid1106.040831"},{"key":"S0899823X00196850_ref017","doi-asserted-by":"publisher","DOI":"10.1086\/320151"},{"key":"S0899823X00196850_ref022","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1083-3"},{"key":"S0899823X00196850_ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-005-1345-3"},{"key":"S0899823X00196850_ref008","doi-asserted-by":"publisher","DOI":"10.1086\/502156"},{"key":"S0899823X00196850_ref015","doi-asserted-by":"publisher","DOI":"10.1086\/501639"},{"key":"S0899823X00196850_ref013","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.6.1417"},{"key":"S0899823X00196850_ref006","doi-asserted-by":"publisher","DOI":"10.1086\/317421"},{"key":"S0899823X00196850_ref014","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1962.03620240029006"},{"key":"S0899823X00196850_ref004","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.11.1244"},{"key":"S0899823X00196850_ref016","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi068"},{"key":"S0899823X00196850_ref019","doi-asserted-by":"publisher","DOI":"10.1086\/323459"},{"key":"S0899823X00196850_ref001","first-page":"9","volume-title":"Primary Care Geriatrics","author":"Mitchell","year":"2002"},{"key":"S0899823X00196850_ref020","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-10-200211190-00007"},{"key":"S0899823X00196850_ref007","doi-asserted-by":"publisher","DOI":"10.1086\/313650"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X00196850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T06:20:41Z","timestamp":1614061241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X00196850\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0899823X00196850"],"URL":"https:\/\/doi.org\/10.1086\/507924","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}