{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:58:30Z","timestamp":1793019510413,"version":"4.5.0"},"reference-count":405,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic ehrlichiosis), and babesiosis were prepared by an expert panel of the Infectious Diseases Society of America. These updated guidelines replace the previous treatment guidelines published in 2000 (Clin Infect Dis 2000; 31[Suppl 1]:1\u201314). The guidelines are intended for use by health care providers who care for patients who either have these infections or may be at risk for them. For each of these Ixodes tickborne infections, information is provided about prevention, epidemiology, clinical manifestations, diagnosis, and treatment. Tables list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided. A definition of post\u2013Lyme disease syndrome is proposed.<\/jats:p>","DOI":"10.1086\/508667","type":"journal-article","created":{"date-parts":[[2006,10,6]],"date-time":"2006-10-06T16:23:47Z","timestamp":1160151827000},"page":"1089-1134","source":"Crossref","is-referenced-by-count":1670,"title":["The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America"],"prefix":"10.1093","volume":"43","author":[{"given":"Gary P.","family":"Wormser","sequence":"first","affiliation":[{"name":"\u00a0Divisions of Infectious Diseases and New York University School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond J.","family":"Dattwyler","sequence":"additional","affiliation":[{"name":"\u00a0Divisions of Allergy, Immunology, and Rheumatology, Department of Medicine, New York Medical College, Valhalla, and New York University School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene D.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"\u00a0Departments of Pediatrics and Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford"},{"name":"\u00a0Departments of Epidemiology and Public Health and Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Halperin","sequence":"additional","affiliation":[{"name":"\u00a0Divisions of New York University School of Medicine, New York, New York"},{"name":"\u00a0Divisions of Atlantic Neuroscience Institute, Summit, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen C.","family":"Steere","sequence":"additional","affiliation":[{"name":"\u00a0Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, and Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Klempner","sequence":"additional","affiliation":[{"name":"\u00a0Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Krause","sequence":"additional","affiliation":[{"name":"\u00a0Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan S.","family":"Bakken","sequence":"additional","affiliation":[{"name":"\u00a0Section of Infectious Diseases, St. Luke's Hospital, Duluth, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc","family":"Strle","sequence":"additional","affiliation":[{"name":"\u00a0Department of Infectious Diseases, University Medical Center, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerold","family":"Stanek","sequence":"additional","affiliation":[{"name":"\u00a0Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Bockenstedt","sequence":"additional","affiliation":[{"name":"\u00a0Departments of Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, and Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durland","family":"Fish","sequence":"additional","affiliation":[{"name":"\u00a0Departments of Epidemiology and Public Health and Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children's Medical Center, Hartford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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