{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:50:22Z","timestamp":1792119022253,"version":"4.4.0"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":2864,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:sec id=\"S0195941700050827_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To quantify the clinical impact of methicillin-resistance in <jats:italic>Staphylococcus aureus<\/jats:italic> causing infection complicated by bacteremia in adult patients, while controlling for the severity of patients' underlying illnesses.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050827_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective cohort study from October 1, 1995, through December 31, 2003.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050827_abs3\"><jats:title>Patients and Setting.<\/jats:title><jats:p>A total of 438 patients with <jats:italic>S. aureus<\/jats:italic> infection complicated by bacteremia from a single Veterans Affairs healthcare system.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050827_abs4\"><jats:title>Results.<\/jats:title><jats:p>We found that 193 (44%) of the 438 patients had methicillin-resistant <jats:italic>S. aureus<\/jats:italic> (MRSA) infection and 114 (26%) died of causes attributable to <jats:italic>S. aureus<\/jats:italic> infection within 90 days after the infection was identified. Patients with MRSA infection had a higher mortality risk, compared with patients with methicillin-susceptible <jats:italic>S. aureus<\/jats:italic> (MSSA) infections (relative risk, 1.7 [95% confidence interval, 1.3-2.4]; <jats:italic>P<\/jats:italic> &lt; .01), except for patients with pneumonia (relative risk, 0.7 [95% confidence interval, 0.4-1.3]). Patients with MRSA infections were significantly older (<jats:italic>P<\/jats:italic> &lt; .01), had more underlying diseases (<jats:italic>P<\/jats:italic> = .02), and were more likely to have severe sepsis in response to their infection (<jats:italic>P<\/jats:italic> &lt; .01) compared with patients with MSSA bacteremia. Patients who died within 90 days after <jats:italic>S. aureus<\/jats:italic> infection was identified were significantly older (<jats:italic>P<\/jats:italic> &lt; .01) and more likely to have severe sepsis (<jats:italic>P<\/jats:italic> &lt; .01) and pneumonia (<jats:italic>P<\/jats:italic> = .01), compared with patients who survived. After adjusting for age as a confounder, comorbidities, and pneumonia as an effect modifier, <jats:italic>S. aureus<\/jats:italic> infection-related mortality remained significantly higher in patients with MRSA infection than in those with MSSA infection, among those without pneumonia (hazard ratio, 1.8 [95% confidence interval, 1.2-3.0]); <jats:italic>P<\/jats:italic> &lt; .01.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050827_abs5\"><jats:title>Conclusions.<\/jats:title><jats:p>The results of this study suggest that patients with MRSA infections other than pneumonia have a higher mortality risk than patients with MSSA infections other than pneumonia, independent of the severity of patients' underlying illnesses.<\/jats:p><\/jats:sec>","DOI":"10.1086\/512627","type":"journal-article","created":{"date-parts":[[2007,2,28]],"date-time":"2007-02-28T16:33:38Z","timestamp":1172680418000},"page":"273-279","source":"Crossref","is-referenced-by-count":189,"title":["Comparison of Mortality Risk Associated With Bacteremia Due to Methicillin-Resistant and Methicillin-Susceptible <i>Staphylococcus aureus<\/i>"],"prefix":"10.1017","volume":"28","author":[{"given":"Simone","family":"Shurland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas D.","family":"Bradham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Claire","family":"Roghmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700050827_ref018","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.11.1244"},{"key":"S0195941700050827_ref021","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-005-3186-5"},{"key":"S0195941700050827_ref017","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/21.6.1417"},{"key":"S0195941700050827_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.02.007"},{"key":"S0195941700050827_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0196-6553(88)90053-3"},{"key":"S0195941700050827_ref004","doi-asserted-by":"publisher","DOI":"10.1086\/501707"},{"key":"S0195941700050827_ref029","doi-asserted-by":"publisher","DOI":"10.1086\/502522"},{"key":"S0195941700050827_ref026","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-9-674"},{"key":"S0195941700050827_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"S0195941700050827_ref009","doi-asserted-by":"publisher","DOI":"10.1086\/502156"},{"key":"S0195941700050827_ref031","doi-asserted-by":"publisher","DOI":"10.1086\/374621"},{"key":"S0195941700050827_ref013","volume-title":"Statistical Methods in Cancer Research, Volume I: The Analysis of Case-Control Studies","author":"Breslow","year":"1993"},{"key":"S0195941700050827_ref015","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.17.2066"},{"key":"S0195941700050827_ref020","doi-asserted-by":"publisher","DOI":"10.2307\/30141354"},{"key":"S0195941700050827_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(99)70031-3"},{"key":"S0195941700050827_ref014","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-3-199302010-00009"},{"key":"S0195941700050827_ref001","doi-asserted-by":"publisher","DOI":"10.1067\/mic.2000.110544"},{"key":"S0195941700050827_ref030","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/29.5.891"},{"key":"S0195941700050827_ref022","doi-asserted-by":"publisher","DOI":"10.1086\/496923"},{"key":"S0195941700050827_ref007","doi-asserted-by":"publisher","DOI":"10.1086\/377611"},{"key":"S0195941700050827_ref028","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198305000-00004"},{"key":"S0195941700050827_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(85)80011-0"},{"key":"S0195941700050827_ref025","doi-asserted-by":"publisher","DOI":"10.1086\/375057"},{"key":"S0195941700050827_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90143-0"},{"key":"S0195941700050827_ref010","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644"},{"key":"S0195941700050827_ref016","doi-asserted-by":"publisher","DOI":"10.1086\/377540"},{"key":"S0195941700050827_ref024","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-346OC"},{"key":"S0195941700050827_ref019","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.19.2229"},{"key":"S0195941700050827_ref006","doi-asserted-by":"publisher","DOI":"10.1086\/345476"},{"key":"S0195941700050827_ref027","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-4-496"},{"key":"S0195941700050827_ref023","doi-asserted-by":"publisher","DOI":"10.1086\/313440"}],"container-title":["Infection Control &amp; 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