{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:23:48Z","timestamp":1773285828068,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1998,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A high incidence of herpes zoster was noticed among patients with AIDS, shortly after addition of a protease inhibitor to their baseline treatment with nucleoside analogue reverse-transcriptase inhibitors. Within a median follow-up of 64 weeks (range, 34\u2013103 weeks), 14 patients (7%) had a first episode or a recurrence of herpes zoster (6.2 episodes per 100 patient-years). No episodes of zoster were diagnosed before week 4. Twelve episodes (86%) occurred between weeks 4 and 16. The risk of zoster was independent of age, sex, type of protease inhibitor, and CD4+ lymphocyte count and viral load at baseline and month 1. A CD8+ lymphocyte proportion at baseline of &amp;gt;66% (hazard ratio [HR], 10.6; 95% confidence interval [CI], 3.4\u201333.1) and an increase in CD8+ lymphocyte proportion at month 1 of &amp;gt;5% (HR, 32; 95% CI, 8.1\u2013126.4) were independently associated with the risk of herpes zoster. These data might be clinically useful for determining transient prophylaxis for those patients at high risk.<\/jats:p>","DOI":"10.1086\/515019","type":"journal-article","created":{"date-parts":[[2007,12,4]],"date-time":"2007-12-04T20:07:35Z","timestamp":1196798855000},"page":"1510-1513","source":"Crossref","is-referenced-by-count":114,"title":["High Incidence of Herpes Zoster in Patients with AIDS Soon After Therapy with Protease Inhibitors"],"prefix":"10.1093","volume":"27","author":[{"given":"Esteban","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"From the Infectious Diseases Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Hospital Cl\u00ednic , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Gatell","sequence":"additional","affiliation":[{"name":"From the Infectious Diseases Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Hospital Cl\u00ednic , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Mor\u00e1n","sequence":"additional","affiliation":[{"name":"From the Infectious Diseases Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Hospital Cl\u00ednic , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Aznar","sequence":"additional","affiliation":[{"name":"From the Infectious Diseases Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Hospital Cl\u00ednic , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Buira","sequence":"additional","affiliation":[{"name":"From the Infectious Diseases Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Hospital Cl\u00ednic , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Guelar","sequence":"additional","affiliation":[{"name":"From the Infectious Diseases Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Hospital Cl\u00ednic , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Mallolas","sequence":"additional","affiliation":[{"name":"From the Infectious Diseases Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Hospital Cl\u00ednic , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eladio","family":"Soriano","sequence":"additional","affiliation":[{"name":"From the Infectious Diseases Unit, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer, Hospital Cl\u00ednic , Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1998,12,1]]},"container-title":["Clinical Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/27\/6\/1510\/67298087\/cid_27_6_1510.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cid\/article-pdf\/27\/6\/1510\/67298087\/cid_27_6_1510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:47:26Z","timestamp":1773229646000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cid\/article\/27\/6\/1510\/317896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1998,12,1]]},"published-print":{"date-parts":[[1998,12,1]]}},"URL":"https:\/\/doi.org\/10.1086\/515019","relation":{},"ISSN":["1537-6591","1058-4838"],"issn-type":[{"value":"1537-6591","type":"electronic"},{"value":"1058-4838","type":"print"}],"subject":[],"published-other":{"date-parts":[[1998,12]]},"published":{"date-parts":[[1998,12,1]]}}}