{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:28:23Z","timestamp":1793089703069,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,19]],"date-time":"2013-07-19T00:00:00Z","timestamp":1374192000000},"content-version":"vor","delay-in-days":2148,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The American Journal of Human Genetics"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1086\/520960","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T16:44:42Z","timestamp":1186591482000},"page":"467-474","source":"Crossref","is-referenced-by-count":217,"title":["Physical Exercise\u2013Induced Hypoglycemia Caused by Failed Silencing of Monocarboxylate Transporter 1 in Pancreatic \u03b2 Cells"],"prefix":"10.1016","volume":"81","author":[{"given":"Timo","family":"Otonkoski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kaminen-Ahola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Tapia-Paez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Parton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Schuit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel","family":"Quintens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Sipil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ertan","family":"Mayatepek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Meissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Halestrap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy A.","family":"Rutter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Kere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1086\/520960_bib3","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1007\/s00125-004-1541-1","article-title":"Visualising insulin secretion: the Minkowski Lecture 2004","volume":"47","author":"Rutter","year":"2004","journal-title":"Diabetologia"},{"key":"10.1086\/520960_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0092-8674(88)90051-7","article-title":"Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and \u03b2-pancreatic islet cells","volume":"55","author":"Thorens","year":"1988","journal-title":"Cell"},{"key":"10.1086\/520960_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2930001","article-title":"Mammalian glucokinase and its gene","volume":"293","author":"Iynedjian","year":"1993","journal-title":"Biochem J"},{"key":"10.1086\/520960_bib6","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1016\/S0021-9258(17)37629-9","article-title":"Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing","volume":"269","author":"Sekine","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1086\/520960_bib7","first-page":"E846","article-title":"Glucose metabolism and insulin release in mouse beta HC9 cells, as model for wild-type pancreatic beta-cells","volume":"270","author":"Liang","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1086\/520960_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0014-5793(98)00600-0","article-title":"Overexpression of lactate dehydrogenase A attenuates glucose-induced insulin secretion in stable MIN-6 beta-cell lines","volume":"430","author":"Zhao","year":"1998","journal-title":"FEBS Lett"},{"key":"10.1086\/520960_bib9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj3290321","article-title":"Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past","volume":"329","author":"Price","year":"1998","journal-title":"Biochem J"},{"key":"10.1086\/520960_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2337\/diabetes.50.2.361","article-title":"Expression and distribution of lactate\/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas","volume":"50","author":"Zhao","year":"2001","journal-title":"Diabetes"},{"key":"10.1086\/520960_bib11","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1172\/JCI7515","article-title":"Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells","volume":"104","author":"Ishihara","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1086\/520960_bib12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/adc.84.3.254","article-title":"Exercise induced hypoglycaemic hyperinsulinism","volume":"84","author":"Meissner","year":"2001","journal-title":"Arch Dis Child"},{"key":"10.1086\/520960_bib13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2337\/diabetes.52.1.199","article-title":"Physical exercise-induced hyperinsulinemic hypoglycemia is an autosomal-dominant trait characterized by abnormal pyruvate-induced insulin release","volume":"52","author":"Otonkoski","year":"2003","journal-title":"Diabetes"},{"key":"10.1086\/520960_bib14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1055\/s-2005-870583","article-title":"Massive insulin secretion in response to anaerobic exercise in exercise-induced hyperinsulinism","volume":"37","author":"Meissner","year":"2005","journal-title":"Horm Metab Res"},{"key":"10.1086\/520960_bib15","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: a unified multipoint approach","volume":"58","author":"Kruglyak","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1086\/520960_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF02900361","article-title":"The Staden sequence analysis package","volume":"5","author":"Staden","year":"1996","journal-title":"Mol Biotechnol"},{"key":"10.1086\/520960_bib17","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.2337\/db06-0774","article-title":"Probe-independent and direct quantification of insulin mRNA and growth hormone mRNA in enriched cell preparations","volume":"55","author":"Van Lommel","year":"2006","journal-title":"Diabetes"},{"key":"10.1086\/520960_bib18","doi-asserted-by":"crossref","first-page":"E390","DOI":"10.1152\/ajpendo.00016.2004","article-title":"Impact of PPAR\u03b3 overexpression and activation on pancreatic islet gene expression profile analyzed with oligonucleotide microarrays","volume":"287","author":"Parton","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1086\/520960_bib19","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1006\/bbrc.2002.6763","article-title":"The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis","volume":"292","author":"Cuff","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1086\/520960_bib20","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1074\/jbc.M511397200","article-title":"The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1\u03b1-dependent mechanism","volume":"281","author":"Ullah","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1086\/520960_bib21","series-title":"Gel retardation assays for DNA-binding proteins: molecular cloning","first-page":"17.13","author":"Sambrook","year":"2001"},{"key":"10.1086\/520960_bib22","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1093\/emboj\/19.15.3896","article-title":"CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression","volume":"19","author":"Kirk","year":"2000","journal-title":"EMBO J"},{"key":"10.1086\/520960_bib23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1042\/bj3430281","article-title":"The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation","volume":"343","author":"Halestrap","year":"1999","journal-title":"Biochem J"},{"key":"10.1086\/520960_bib24","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00424-003-1067-2","article-title":"The SLC16 gene family\u2014from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond","volume":"447","author":"Halestrap","year":"2004","journal-title":"Pflugers Arch"},{"key":"10.1086\/520960_bib25","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.2174\/1381612054546879","article-title":"Insulin secretagogues, sulfonylurea receptors and K(ATP) channels","volume":"11","author":"Bryan","year":"2005","journal-title":"Curr Pharm Des"},{"key":"10.1086\/520960_bib26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1042\/bj3350533","article-title":"AMP-activated protein kinase is activated by low glucose in cell lines derived from pancreatic beta cells, and may regulate insulin release","volume":"335","author":"Salt","year":"1998","journal-title":"Biochem J"}],"container-title":["The American Journal of Human Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707613445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002929707613445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T07:45:23Z","timestamp":1629531923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002929707613445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0002929707613445"],"URL":"https:\/\/doi.org\/10.1086\/520960","relation":{},"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}