{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:11:43Z","timestamp":1790079103343,"version":"4.0.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":2589,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:sec id=\"S0195941700026382_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To identify independent risk factors associated with isolation of linezolid-resistant, vancomycin-resistant <jats:italic>Enterococcus<\/jats:italic> (VRE).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700026382_abs2\"><jats:title>Design.<\/jats:title><jats:p>A retrospective, case-case-control study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700026382_abs3\"><jats:title>Setting.<\/jats:title><jats:p>A tertiary care, academic medical center.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700026382_abs4\"><jats:title>Methods.<\/jats:title><jats:p>VRE isolates from clinical cultures were retrospectively analyzed for linezolid resistance during our 18-month study period. Clinical data were obtained from electronic patient records, and the risk factors associated with isolation of linezolid-resistant VRE were determined by comparison of 2 case groups with a control group.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700026382_abs5\"><jats:title>Results.<\/jats:title><jats:p>A total of 20% of the VRE isolates analyzed during the study period were linezolid resistant, and resistant isolates were most commonly recovered from the urine (40% of resistant isolates). Risk factors found to be associated with isolation of linezolid-resistant VRE were peripheral vascular disease and\/or the receipt of a solid organ transplant, total parenteral nutrition, piperacillin-tazobactam, and\/or cefepime. Only 25% of patients from whom linezolid-resistant VRE was isolated had previous linezolid exposure, and in the multivariate model this was not found to be a risk factor associated with the isolation of linezolid-resistant VRE.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700026382_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>The results of this analysis suggest that there is horizontal transmission of linezolid-resistant VRE in our institution and highlight the need for improved infection control measures. Furthermore, the high incidence of linezolid-resistant VRE demands a reassessment of our empirical antibiotic selection for patients infected with VRE.<\/jats:p><\/jats:sec>","DOI":"10.1086\/523276","type":"journal-article","created":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T05:59:57Z","timestamp":1196834397000},"page":"1382-1388","source":"Crossref","is-referenced-by-count":50,"title":["Determination of Risk Factors Associated With Isolation of Linezolid-Resistant Strains of Vancomycin-Resistant <i>Enterococcus<\/i>"],"prefix":"10.1017","volume":"28","author":[{"given":"Jason M.","family":"Pogue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. William","family":"Pasculle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Potoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700026382_ref010","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-006-0100-8"},{"key":"S0195941700026382_ref007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200203143461121"},{"key":"S0195941700026382_ref011","doi-asserted-by":"publisher","DOI":"10.3201\/eid1307.070019"},{"key":"S0195941700026382_ref004","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1C437"},{"key":"S0195941700026382_ref021","doi-asserted-by":"publisher","DOI":"10.1086\/502548"},{"key":"S0195941700026382_ref008","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00850-06"},{"key":"S0195941700026382_ref006","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki318"},{"key":"S0195941700026382_ref018","doi-asserted-by":"publisher","DOI":"10.1086\/502550"},{"key":"S0195941700026382_ref017","doi-asserted-by":"publisher","DOI":"10.1086\/340533"},{"key":"S0195941700026382_ref013","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000217961.75225.E9"},{"key":"S0195941700026382_ref003","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.1153-1155.2006"},{"key":"S0195941700026382_ref025","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.5024-5032.2005"},{"key":"S0195941700026382_ref024","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.02.019"},{"key":"S0195941700026382_ref020","doi-asserted-by":"publisher","DOI":"10.1086\/338237"},{"key":"S0195941700026382_ref019","doi-asserted-by":"publisher","DOI":"10.1086\/340532"},{"key":"S0195941700026382_ref001","doi-asserted-by":"publisher","DOI":"10.1086\/344177"},{"key":"S0195941700026382_ref022","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00850-06"},{"key":"S0195941700026382_ref009","doi-asserted-by":"publisher","DOI":"10.1086\/374929"},{"key":"S0195941700026382_ref002","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2004.01036.x"},{"key":"S0195941700026382_ref014","doi-asserted-by":"publisher","DOI":"10.1086\/339211"},{"key":"S0195941700026382_ref015","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-145"},{"key":"S0195941700026382_ref016","first-page":"M100","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: 15th Informational Supplement","year":"2004"},{"key":"S0195941700026382_ref005","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.13.1225.38086"},{"key":"S0195941700026382_ref023","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki437"},{"key":"S0195941700026382_ref012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200203143461121"},{"key":"S0195941700026382_ref026","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00131-06"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700026382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T15:43:46Z","timestamp":1556725426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700026382\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S0195941700026382"],"URL":"https:\/\/doi.org\/10.1086\/523276","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}