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Viral gene expression and viral particle production of glucose-6-phosphate dehydrogenase (G6PD)\u2013deficient and G6PD-knockdown cells were much higher than their counterparts when human coronavirus (HCoV) 229E was applied at 0.1 multiplicity of infection. These phenomena were correlated with increased oxidant production. Accordingly, ectopic expression of G6PD in G6PD-deficient cells or addition of antioxidant (such as \u03b1-lipoic acid) to G6PD-knockdown cells attenuated the increased susceptibility to HCoV 229E infection. All experimental data indicated that oxidative stress in host cells is an important factor in HCoV 229E infectivity<\/jats:p>","DOI":"10.1086\/528377","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T17:30:59Z","timestamp":1202837459000},"page":"812-816","source":"Crossref","is-referenced-by-count":106,"title":["Glucose-6-Phosphate Dehydrogenase Deficiency Enhances Human Coronavirus 229E Infection"],"prefix":"10.1093","volume":"197","author":[{"given":"Yi-Hsuan","family":"Wu","sequence":"first","affiliation":[{"name":"Graduate Institute of Basic Medical Sciences and Graduate Institute of Medical Biotechnology, Chang Gung University, and Department of Clinical Pathology, Chang Gung Memorial Hospital Kwei-Shan, Tao-Yuan, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Ping","family":"Tseng","sequence":"first","affiliation":[{"name":"Graduate Institute of Basic Medical Sciences and Graduate Institute of Medical 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