{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:52:15Z","timestamp":1791035535857,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J INFECT DIS"],"published-print":{"date-parts":[[2008,7,15]]},"DOI":"10.1086\/589515","type":"journal-article","created":{"date-parts":[[2008,5,20]],"date-time":"2008-05-20T19:48:49Z","timestamp":1211312929000},"page":"275-283","source":"Crossref","is-referenced-by-count":78,"title":["Metronidazole Lacks Activity against<i>Mycobacterium tuberculosis<\/i>in an In Vivo Hypoxic Granuloma Model of Latency"],"prefix":"10.1093","volume":"198","author":[{"given":"Lee\u00a0G.","family":"Klinkenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley\u00a0A.","family":"Sutherland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William\u00a0R.","family":"Bishai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros\u00a0C.","family":"Karakousis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"key":"rf1_195","first-page":"677","volume":"282","author":"Dye C","year":"1999","journal-title":"WHO Global Surveillance and Monitoring Project. JAMA"},{"key":"rf2_196","doi-asserted-by":"publisher","DOI":"10.1086\/338342"},{"key":"rf3_197","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00741-2"},{"key":"rf4_198","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-829504"},{"key":"rf5_199","first-page":"1","volume":"4","author":"Opie EL","year":"1927","journal-title":"Arch Pathol Lab Med"},{"key":"rf6_200","unstructured":"Adler JJ, Rose DN. Transmission and pathogenesis of tuberculosis. In: Rom WN, Garay SM, eds. Tuberculosis. 1st ed. Boston: Little, Brown & Company, 1996:1002."},{"key":"rf7_201","unstructured":"Canetti G. The tubercle bacillus in the pulmonary lesion of man: histobacteriology and its bearing on the therapy of pulmonary tuberculosis. American rev. ed. New York: Springer, 1955."},{"key":"rf8_202","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1128\/IAI.64.6.2062-2069.1996","volume":"64","author":"Wayne LG","year":"1996","journal-title":"Infect Immun"},{"key":"rf9_203","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1128\/IAI.17.3.528-530.1977","volume":"17","author":"Wayne LG","year":"1977","journal-title":"Infect Immun"},{"key":"rf10_204","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1128\/AAC.38.9.2054","volume":"38","author":"Wayne LG","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"rf11_205","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/31.1.9"},{"key":"rf12_206","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1128\/AAC.43.5.1285","volume":"43","author":"Brooks JV","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"rf13_207","first-page":"736","volume":"2","author":"Dhillon J","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"rf14_208","doi-asserted-by":"publisher","DOI":"10.1002\/path.2055"},{"key":"rf15_209","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00612.x"},{"key":"rf16_210","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040646"},{"key":"rf17_211","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030205"},{"key":"rf18_212","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1231432100"},{"key":"rf19_213","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.4.1645"},{"key":"rf20_214","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2003.12.006"},{"key":"rf21_215","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03474.x"},{"key":"rf22_216","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121172498"},{"key":"rf23_217","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2004.02.003"},{"key":"rf24_218","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.13.3485-3491.2002"},{"key":"rf25_219","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00254-4"},{"key":"rf26_220","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00713-6"},{"key":"rf27_221","unstructured":"Ausubel FM. Current protocols in molecular biology. New York: Greene Pub. Associates and Wiley-Interscience: J Wiley, 1991."},{"key":"rf28_222","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.4.2533-2540.2005"},{"key":"rf29_223","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.091062498"},{"key":"rf30_224","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/bjc.1995.429","volume":"72","author":"Arteel GE","year":"1995","journal-title":"Br J Cancer"},{"key":"rf31_225","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/bjc.1989.69","volume":"59","author":"MacManus MP","year":"1989","journal-title":"Br J Cancer"},{"key":"rf32_226","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1126"},{"key":"rf33_227","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00276-07"},{"key":"rf34_228","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.3.271"},{"key":"rf35_229","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.1996.d01-78.x"},{"key":"rf36_230","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1128\/AAC.37.3.407","volume":"37","author":"Lalande V","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"rf37_231","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm485"},{"key":"rf38_232","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.24.6760-6767.2002"},{"key":"rf39_233","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000238655","volume":"35","author":"Brook I","year":"1989","journal-title":"Chemotherapy"},{"key":"rf40_234","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/infdis\/143.3.487","volume":"143","author":"Joiner KA","year":"1981","journal-title":"J Infect Dis"}],"container-title":["The Journal of Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jid\/article-pdf\/198\/2\/275\/18054628\/198-2-275.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T21:34:32Z","timestamp":1588714472000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jid\/article-lookup\/doi\/10.1086\/589515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,15]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,7,15]]}},"alternative-id":["10.1086\/589515"],"URL":"https:\/\/doi.org\/10.1086\/589515","relation":{},"ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,15]]}}}