{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:22:09Z","timestamp":1761578529248},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":2345,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:sec id=\"S0195941700048736_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To estimate the risk of bloodstream infection associated with catheter dwell time in infants.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700048736_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700048736_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Duke University Medical Center neonatal intensive care unit, an academic, level 3 nursery in Durham, North Carolina.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700048736_abs4\"><jats:title>Methods.<\/jats:title><jats:p>A case of catheter-associated bloodstream infection was defined as one that occurred in an infant whose culture-positive blood sample was collected more than 24 hours after catheter insertion or within 72 hours after catheter removal. We used multivariable logistic regression to control for the catheter's position and dwell time as well as the infant's sex, gestational age, age at time of catheter insertion, birth weight, and weight at time of catheter insertion.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700048736_abs5\"><jats:title>Results.<\/jats:title><jats:p>We identified 135 cases of catheter-associated bloodstream infection. The mean catheter dwell time was 12.2 days (range, 0\u2013113 days), and the mean time to bloodstream infection was 10.8 days (range, 1\u201357 days). An increase in catheter dwell time was associated with a lower risk of bloodstream infection (odds ratio, 0.975 [95% confidence interval, 0.954\u20130.996]; <jats:italic>P<\/jats:italic> = .02).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700048736_abs6\"><jats:title>Conclusion. No<\/jats:title><jats:p>increased risk of catheter-associated bloodstream infection was observed with increased catheter dwell time. This may have been due to the infant's improved nutrition, decreased need for other invasive devices, and maturing skin and immune system as catheter dwell time increased.<\/jats:p><\/jats:sec>","DOI":"10.1086\/589905","type":"journal-article","created":{"date-parts":[[2008,6,26]],"date-time":"2008-06-26T20:39:00Z","timestamp":1214512740000},"page":"749-753","source":"Crossref","is-referenced-by-count":24,"title":["Is an Increased Dwell Time of a Peripherally Inserted Catheter Associated With an Increased Risk of Bloodstream Infection in Infants?"],"prefix":"10.1017","volume":"29","author":[{"given":"P. Brian","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Daniel K.","family":"Benjamin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Michael","family":"Cotten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Nowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Laura","family":"Smithwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Courtney D.","family":"Thornburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700048736_ref005","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1990.02150350078030"},{"key":"S0195941700048736_ref007","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211655"},{"key":"S0195941700048736_ref011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199210083271505"},{"key":"S0195941700048736_ref003","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-1785"},{"key":"S0195941700048736_ref015","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2292"},{"key":"S0195941700048736_ref010","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211125"},{"key":"S0195941700048736_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(86)80201-9"},{"key":"S0195941700048736_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2004.10.001"},{"key":"S0195941700048736_ref014","first-page":"99","article-title":"Outcome of treatment of candidemia in children whose central catheters were removed or retained","volume":"8","author":"Eppes","year":"1989","journal-title":"Pediatr Infect Dis J"},{"key":"S0195941700048736_ref006","first-page":"1","article-title":"Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention","volume":"51","author":"O'Grady","year":"2002","journal-title":"MMWR Recomm Rep"},{"key":"S0195941700048736_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(98)90139-6"},{"key":"S0195941700048736_ref004","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.2.285"},{"key":"S0195941700048736_ref002","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200206000-00006"},{"key":"S0195941700048736_ref013","doi-asserted-by":"publisher","DOI":"10.1542\/peds.107.6.1272"},{"key":"S0195941700048736_ref012","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.5.e63"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700048736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T22:51:03Z","timestamp":1556664663000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700048736\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["S0195941700048736"],"URL":"https:\/\/doi.org\/10.1086\/589905","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]}}}