{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:43:01Z","timestamp":1780591381106,"version":"3.54.1"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":2192,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:sec id=\"S0195941700027351_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To evaluate the prevalence, epidemiologic features, and molecular characteristics of colonization with community-associated methicillin-resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(CA-MRSA) among hospitalized dialysis patients and their healthcare workers (HCWs).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027351_abs2\"><jats:title>Design.<\/jats:title><jats:p>Prospective observational clinical and laboratory study of nasal colonization.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027351_abs3\"><jats:title>Setting.<\/jats:title><jats:p>A 600-bed urban academic medical center.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027351_abs4\"><jats:title>Subjects.<\/jats:title><jats:p>One hundred twenty hospitalized dialysis inpatients and 100 HCWs.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027351_abs5\"><jats:title>Results.<\/jats:title><jats:p>Of 120 patients, 40 (33%) were colonized with<jats:italic>S. aureus<\/jats:italic>; 26 (65%) of these 40 were colonized with MRSA. Among the 26 MRSA isolates, 10 (38.5%) carried staphylococcal cassette chromosome (SCC)<jats:italic>mec<\/jats:italic>type IV (ie, CA-MRSA), and 7 of these 10 carried the genes for the Panton-Valentine leukocidin (PVL) toxin. Patients colonized with healthcare-associated MRSA strains and those colonized with CA-MRSA strains were similar, except for a higher frequency of a history of congestive heart failure among those with healthcare-associated MRSA strains (<jats:italic>P<\/jats:italic>= .014). Among 10 patients who presented with or developed an<jats:italic>S. aureus<\/jats:italic>infection while hospitalized, 8 were colonized with<jats:italic>S. aureus<\/jats:italic>, 7 with MRSA, and 3 with SCC<jats:italic>mec<\/jats:italic>type IV strains. Among 100 HCWs, 31 were colonized with<jats:italic>S. aureus<\/jats:italic>, including 6 with MRSA; 2 of the MRSA isolates belonged to CA-MRSA strains, and soft-tissue infections were reported in one of the HCWs and in the family member of the other HCW colonized with these strains.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027351_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>There is a high rate of colonization with MRSA and CA-MRSA among hospitalized dialysis patients and their HCWs. As other studies have found, it appears that individuals are being colonized with both CA-MRSA strains and healthcare-associated MRSA strains.<\/jats:p><\/jats:sec>","DOI":"10.1086\/592983","type":"journal-article","created":{"date-parts":[[2008,12,2]],"date-time":"2008-12-02T00:22:18Z","timestamp":1228177338000},"page":"4-8","source":"Crossref","is-referenced-by-count":50,"title":["Prevalence of Colonization With Community-Associated Methicillin-Resistant<i>Staphylococcus aureus<\/i>Among End-Stage Renal Disease Patients and Healthcare Workers"],"prefix":"10.1017","volume":"30","author":[{"given":"Leonard B.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinson","family":"Jose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Yousif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Pawlak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis D.","family":"Saravolatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700027351_ref004","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-5-200603070-00005"},{"key":"S0195941700027351_ref002","doi-asserted-by":"publisher","DOI":"10.1086\/502231"},{"key":"S0195941700027351_ref007","doi-asserted-by":"publisher","DOI":"10.1086\/507923"},{"key":"S0195941700027351_ref027","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00880-06"},{"key":"S0195941700027351_ref023","doi-asserted-by":"publisher","DOI":"10.1086\/528716"},{"key":"S0195941700027351_ref006","doi-asserted-by":"publisher","DOI":"10.1086\/499815"},{"key":"S0195941700027351_ref003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055356"},{"key":"S0195941700027351_ref013","doi-asserted-by":"publisher","DOI":"10.1086\/507970"},{"key":"S0195941700027351_ref010","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.11.5113-5120.2003"},{"key":"S0195941700027351_ref012","doi-asserted-by":"publisher","DOI":"10.1086\/423965"},{"key":"S0195941700027351_ref005","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-3-325"},{"key":"S0195941700027351_ref018","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.11.5113-5120.2003"},{"key":"S0195941700027351_ref009","first-page":"197","article-title":"Centers for Disease Control and Prevention. 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