{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:28:33Z","timestamp":1761290913288},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":2161,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:sec id=\"S0195941700027673_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To describe the incidence of recovery of both vancomycin-resistant enterococci (VRE) and methicillin-resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(MRSA) from culture of a single clinical specimen, to describe the clinical characteristics of patients from whom these specimens were recovered, and to identify the risk factors of these patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027673_abs2\"><jats:title>Design.<\/jats:title><jats:p>A retrospective cohort and case-control study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027673_abs3\"><jats:title>Setting.<\/jats:title><jats:p>A tertiary care university hospital and referral center in Seoul, Korea.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027673_abs4\"><jats:title>Methods.<\/jats:title><jats:p>We identified 61 case patients for whom a single clinical specimen yielded both VRE and MRSA on culture, and 122 control patients for whom any clinical specimen yielded only VRE on culture. The control patients were selected by matching 2 :1 with the case patients for age, sex, and first date of sampling that led to isolation of VRE or both VRE and MRSA among 1,536 VRE-colonized patients from January 1, 2003, through December 31, 2006. To identify patient risk factors for the recovery of both VRE and MRSA in a single clinical specimen, we performed univariate comparisons between the 2 groups and then multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027673_abs5\"><jats:title>Results.<\/jats:title><jats:p>The incidence of recovery of both VRE and MRSA from culture of a single clinical specimen was 3.97% (for 61 of 1,536 VRE-colonized patients) over 4 years. Among these 82 single clinical specimens, the most common type was wound specimens (26.8%), followed by lower respiratory tract specimens (18.3%), urine specimens (17.1%), and catheter tips (15.9%). Of the 61 case patients, 14 (23.0%) had 2 or more single clinical specimens that yielded both VRE and MRSA on culture, and the longest interval from the first sampling that yielded both organisms to the last sampling that yielded both was 174 days. Independent patient risk factors for the presence of both VRE and MRSA in a single clinical specimen were chronic renal disease (odds ratio [OR], 7.00;<jats:italic>P<\/jats:italic>= .012), urinary catheterization (OR, 3.36;<jats:italic>P<\/jats:italic>= .026), and longer total cumulative duration of hospital stay within the previous year (OR, 1.03;<jats:italic>P<\/jats:italic>&lt; .001).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700027673_abs6\"><jats:title>Conclusion.<\/jats:title><jats:p>We confirmed that the recovery of VRE and MRSA from a single clinical specimen occurs continually. Because prolonged cell-to-cell contact can facilitate transfer of<jats:italic>vanA,<\/jats:italic>close observation and surveillance for vancomycin-resistant<jats:italic>S. aureus<\/jats:italic>, especially among patients with risk factors for the recovery of both VRE and MRSA from a single clinical specimen, should be continued.<\/jats:p><\/jats:sec>","DOI":"10.1086\/593957","type":"journal-article","created":{"date-parts":[[2009,1,7]],"date-time":"2009-01-07T22:55:06Z","timestamp":1231368906000},"page":"130-138","source":"Crossref","is-referenced-by-count":11,"title":["Recovery of Both Vancomycin-Resistant Enterococci and Methicillin-Resistant<i>Staphylococcus aureus<\/i>From Culture of a Single Clinical Specimen From Colonized or Infected Patients"],"prefix":"10.1017","volume":"30","author":[{"given":"Sang Hoon","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bum Sik","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Sung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su Jin","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Kyung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Oh","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongeun","family":"Yong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Yong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Goo","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Myung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700027673_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2004.10.001"},{"key":"S0195941700027673_ref009","doi-asserted-by":"publisher","DOI":"10.1086\/430909"},{"key":"S0195941700027673_ref010","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01344.x"},{"key":"S0195941700027673_ref008","doi-asserted-by":"publisher","DOI":"10.1086\/345476"},{"key":"S0195941700027673_ref020","article-title":"Methods used for the isolation, enumeration, characterisation and identification of Enterococcus spp. 1. 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