{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:31:11Z","timestamp":1790465471795,"version":"4.1.0"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":2041,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:sec id=\"S0195941700037036_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To determine the rates of and risk factors for carriage and acquisition of extended-spectrum (\u03b2-lactamase (ESBL)-producing Enterobacteriaceae during hospitalization.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037036_abs2\"><jats:title>Design.<\/jats:title><jats:p>Cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037036_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Shaare Zedek Medical Center, a 550-bed teaching hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037036_abs4\"><jats:title>Methods.<\/jats:title><jats:p>During a 5-month period (February 1-June 30, 2004), 167 (8%) of 1,985 newly admitted general medical patients were enrolled in our study. Nasal, oropharyngeal, and rectal swab specimens were obtained at admission and every 2-3 days until hospital discharge or death. Enterobacteriaceae isolates were tested for ESBL, and<jats:italic>Staphylococcus aureus<\/jats:italic>isolates were tested for methicillin resistance.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037036_abs5\"><jats:title>Results.<\/jats:title><jats:p>Of the 167 patients enrolled in our study, 15 (9%) were identified as nasal carriers of methicillin-resistant<jats:italic>S. aureus<\/jats:italic>(MRSA) at admission, and 13 (8%) were rectal carriers of ESBL-producing Enterobacteriaceae at admission. Univariate risk factors for rectal carriage of ESBL-producing Enterobacteriaceae included female sex (odds ratio [OR], 11 [95% confidence interval {CI}, 1.4\u2014238];<jats:italic>P<\/jats:italic>&lt; .05), nursing home residence (OR, 6.9 [95% CI, 1.8-27];<jats:italic>P<\/jats:italic>&lt; .01), recent antibiotic treatment (OR, 9.8 [95% CI, 1.7-74];<jats:italic>P<\/jats:italic>&lt; .05), and concomitant nasal carriage of MRSA and\/or ESBL-producing Enterobacteriaceae (OR, 5.8 [95% CI, 1.2-26];<jats:italic>P<\/jats:italic>&lt; .01). Multivariate risk factors were female sex and recent antibiotic treatment. During hospitalization, 35 (21%) of 167 patients had acquired rectal carriage of ESBL-producing Enterobacteriaceae (<jats:italic>P<\/jats:italic>= .002, for trend analysis). Of the 12 patients who were still in the hospital 2 weeks after admission, 4 (33%) were carriers of ESBL-producing Enterobacteriaceae. Univariate risk factors for acquisition included an age of older than 65 years (<jats:italic>P<\/jats:italic>&lt; .005), nursing home residence (OR 2.6, [95% CI, 0.98-2.6]), impaired cognition (OR, 4.8 [95% CI, 1.9-12]), recent antibiotic treatment (OR, 2.7 [95% CI, 0.9-8.3]), respiratory assistance (OR, 4.2 [95% CI, 1.2-14]), and prolonged hospitalization. Multivariate risk factors were an age of older than 65 years and broad-spectrum antibiotic therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037036_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>Rectal carriage of ESBL-producing Enterobacteriaceae occurred in 13 (8%) of 167 patients at admission to the medical departments of our hospital and in 4 (33%) of 12 patients still remaining in our hospital after 2 weeks.<\/jats:p><\/jats:sec>","DOI":"10.1086\/597505","type":"journal-article","created":{"date-parts":[[2009,5,6]],"date-time":"2009-05-06T14:37:03Z","timestamp":1241620623000},"page":"534-542","source":"Crossref","is-referenced-by-count":104,"title":["Prospective Evaluation of Colonization with Extended-Spectrum \u03b2-Lactamase (ESBL)\u2013Producing Enterobacteriaceae Among Patients at Hospital Admission and of Subsequent Colonization with ESBL-Producing Enterobacteriaceae Among Patients During Hospitalization"],"prefix":"10.1017","volume":"30","author":[{"given":"Reuven","family":"Friedmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Raveh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Zartzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Rudensky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Broide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Attias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos M.","family":"Yinnon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700037036_ref001","doi-asserted-by":"publisher","DOI":"10.1086\/344654"},{"key":"S0195941700037036_ref026","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1128\/JCM.38.11.4228-4232.2000","article-title":"Detection of extended-spectrum \u03b2-lactamases in klebsiellae with the Oxoid combination disc method","volume":"38","author":"Carter","year":"2000","journal-title":"J Clin Microbiol"},{"key":"S0195941700037036_ref021","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-006-4114-z"},{"key":"S0195941700037036_ref012","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-1084-2"},{"key":"S0195941700037036_ref023","doi-asserted-by":"publisher","DOI":"10.1086\/501697"},{"key":"S0195941700037036_ref036","doi-asserted-by":"publisher","DOI":"10.1086\/319757"},{"key":"S0195941700037036_ref033","doi-asserted-by":"publisher","DOI":"10.1179\/joc.2003.15.6.568"},{"key":"S0195941700037036_ref025","volume-title":"Performance standards for antimicrobial susceptibility testing: 16th informational supplement","year":"2006"},{"key":"S0195941700037036_ref022","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcl050"},{"key":"S0195941700037036_ref011","doi-asserted-by":"publisher","DOI":"10.3201\/eid1307.070094"},{"key":"S0195941700037036_ref037","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.6.2206-2212.2001"},{"key":"S0195941700037036_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.07.007"},{"key":"S0195941700037036_ref029","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.10.4769-4775.2004"},{"key":"S0195941700037036_ref028","first-page":"847","article-title":"Methicillin-resistant Staphylococcus aureus nasal colonization in children in Jerusalem: community vs. chronic care institutions","volume":"5","author":"Schlesinger","year":"2003","journal-title":"Isr Med Assoc J"},{"key":"S0195941700037036_ref003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01857.x"},{"key":"S0195941700037036_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(97)90163-8"},{"key":"S0195941700037036_ref035","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01509-06"},{"key":"S0195941700037036_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(03)00286-X"},{"key":"S0195941700037036_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70041-0"},{"key":"S0195941700037036_ref015","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.00925.x"},{"key":"S0195941700037036_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(03)00053-1"},{"key":"S0195941700037036_ref013","first-page":"CR44","article-title":"Extended-spectrum \u03b2-lactamase-producing Enterobacteriaceae strains in community-acquired bacteremia in southern Israel","volume":"8","author":"Borer","year":"2002","journal-title":"Med Sci Monit"},{"key":"S0195941700037036_ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2753.2004.00492.x"},{"key":"S0195941700037036_ref008","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01866.x"},{"key":"S0195941700037036_ref024","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/94.3.141"},{"key":"S0195941700037036_ref002","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.4.657-686.2005"},{"key":"S0195941700037036_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01862.x"},{"key":"S0195941700037036_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.01.019"},{"key":"S0195941700037036_ref010","doi-asserted-by":"publisher","DOI":"10.1097\/IPC.0b013e31816613de"},{"key":"S0195941700037036_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(99)00062-0"},{"key":"S0195941700037036_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2008.02.003"},{"key":"S0195941700037036_ref018","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1007\/s10096-003-0905-7","article-title":"An improved, evidence-based method for empirical treatment of urinary tract infection","volume":"22","author":"Raveh","year":"2003","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"S0195941700037036_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70295-4"},{"key":"S0195941700037036_ref038","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/00365540151060806","article-title":"Clinical significance and impact on mortality of extended-spectrum \u03b2 lactamase-producing Enterobacteriaceae isolates in nosocomial bacteremia","volume":"33","author":"Menashe","year":"2001","journal-title":"Scand J Infect Dis"},{"key":"S0195941700037036_ref039","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01870.x"},{"key":"S0195941700037036_ref040","doi-asserted-by":"publisher","DOI":"10.1086\/521260"},{"key":"S0195941700037036_ref031","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2006.12.50"},{"key":"S0195941700037036_ref032","doi-asserted-by":"publisher","DOI":"10.1086\/502521"},{"key":"S0195941700037036_ref030","doi-asserted-by":"publisher","DOI":"10.1086\/522678"},{"key":"S0195941700037036_ref004","doi-asserted-by":"publisher","DOI":"10.1086\/505919"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700037036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T23:53:16Z","timestamp":1589759596000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700037036\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0195941700037036"],"URL":"https:\/\/doi.org\/10.1086\/597505","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}