{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:37:16Z","timestamp":1789659436141,"version":"4.0.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":1919,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:sec id=\"S0195941700037784_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To compare the effects of different skin preparation solutions on surgical-site infection rates.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037784_abs2\"><jats:title>Design.<\/jats:title><jats:p>Three skin preparations were compared by means of a sequential implementation Design. Each agent was adopted as the preferred modality for a 6-month period for all general surgery cases. Period 1 used a povidone-iodine scrub-paint combination (Betadine) with an isopropyl alcohol application between these steps, period 2 used 2% Chlorhexidine and 70% isopropyl alcohol (ChloraPrep), and period 3 used iodine povacrylex in isopropyl alcohol (DuraPrep). Surgical-site infections were tracked for 30 days as part of ongoing data collection for the National Surgical Quality Improvement Project initiative. The primary outcome was the overall rate of surgical-site infection by 6-month period performed in an intent-to-treat manner.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037784_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Single large academic medical center.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037784_abs4\"><jats:title>Patients.<\/jats:title><jats:p>All adult general surgery patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037784_abs5\"><jats:title>Results.<\/jats:title><jats:p>The study comprised 3,209 operations. The lowest infection rate was seen in period 3, with iodine povacrylex in isopropyl alcohol as the preferred preparation method (3.9%, compared with 6.4% for period 1 and 7.1% for period 2;<jats:italic>P<\/jats:italic>= .002). In subgroup analysis, no difference in outcomes was seen between patients prepared with povidone-iodine scrub-paint and those prepared with iodine povacrylex in isopropyl alcohol, but patients in both these groups had significantly lower surgical-site infection rates, compared with rates for patients prepared with 2% Chlorhexidine and 70% isopropyl alcohol (4.8% vs 8.2%;<jats:italic>P<\/jats:italic>= .001).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700037784_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>Skin preparation solution is an important factor in the prevention of surgical-site infections. Iodophor-based compounds may be superior to Chlorhexidine for this purpose in general surgery patients.<\/jats:p><\/jats:sec>","DOI":"10.1086\/605926","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T16:51:58Z","timestamp":1252083118000},"page":"964-971","source":"Crossref","is-referenced-by-count":187,"title":["Effects of Preoperative Skin Preparation on Postoperative Wound Infection Rates A Prospective Study of 3 Skin Preparation Protocols"],"prefix":"10.1017","volume":"30","author":[{"given":"Brian R.","family":"Swenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traci L.","family":"Hedrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Metzger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Bonatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Pruett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Sawyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700037784_ref002","doi-asserted-by":"publisher","DOI":"10.1086\/501572"},{"key":"S0195941700037784_ref018","doi-asserted-by":"publisher","DOI":"10.1177\/107110070102200415"},{"key":"S0195941700037784_ref014","unstructured":"MedQIP-SCIP. 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