{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T05:34:41Z","timestamp":1767159281846,"version":"build-2238731810"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"unspecified","delay-in-days":9395,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A cross-sectional serological survey was undertaken in 82 randomly selected high-risk healthcare workers previously vaccinated with the hepatitis B vaccine. The study design allowed for the identification and testing for hepatitis B surface antibody in equal numbers of employees in six-month intervals up to five years after vaccination. The results showed a consistent decline in antibody level with time, and an increasing proportion of participants with antibody levels below the commonly accepted protective level of \u226510 S\/N (sample counts\/negative control counts) radioimmunoassay units. The percent of vaccinees whose S\/N ratio was greater than 10 fell from 10% at one year, to 25% at two years, to over 50% at four years. Based on these figures, as well as the financial costs of hepatitis B in employees and the predictability of booster immunization, it was possible to assess the cost benefit of a hospital policy for reimmunization. At our institution, a strategy of revaccination at fixed intervals could save up to $200,000 over a ten-year period if revaccination was not offered and vaccine efficacy declined. The information obtained should help determine the need for revaccination and the advantages and disadvantages of alternative revaccination strategies.<\/jats:p>","DOI":"10.1086\/646086","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T12:21:01Z","timestamp":1251807661000},"page":"525-530","source":"Crossref","is-referenced-by-count":11,"title":["Persistence of Antibody in Healthcare Workers Vaccinated Against Hepatitis B"],"prefix":"10.1017","volume":"11","author":[{"given":"Alan C.","family":"Street","sequence":"first","affiliation":[{"name":"Duke University Medical Center"},{"name":"Duke University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa Z.","family":"Weddle","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne R.","family":"Thomann","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen W.","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George W.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Duke University Medical Center"},{"name":"Duke University Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2016,6,21]]},"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0899823X00083999","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:36:07Z","timestamp":1762331767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0899823X00083999\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":0,"aliases":["10.2307\/30151320","10.2307\/30151320"],"journal-issue":{"issue":"10","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["S0899823X00083999"],"URL":"https:\/\/doi.org\/10.1086\/646086","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]}}}