{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T15:24:57Z","timestamp":1775921097243,"version":"3.50.1"},"reference-count":29,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"unspecified","delay-in-days":8299,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0899823X00092321_abs1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To evaluate measures intended to reduce\n                      <jats:italic>Legionella<\/jats:italic>\n                      infections in patients undergoing bone marrow transplantation (BMT).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00092321_abs2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      Ongoing clinical and microbiological surveillance for\n                      <jats:italic>Legionella<\/jats:italic>\n                      colonization or infection was undertaken. All neutropenic patients with pulmonary infiltrates and fever unresponsive to broad-spectrum antibiotics were tested for\n                      <jats:italic>Legionella<\/jats:italic>\n                      organisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00092321_abs3\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>A 505-bed medical-surgical hospital with a designated BMT unit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00092321_abs4\">\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>\n                      Two hundred twenty-five patients underwent BMT; 201 were treated on a new BMT unit. The incidence of\n                      <jats:italic>Legionella<\/jats:italic>\n                      infections was compared to that seen in an estimated 150 neutropenic patients treated on other units.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00092321_abs5\">\n                    <jats:title>Intervention:<\/jats:title>\n                    <jats:p>\n                      A combined approach to decontamination of a hospital water supply was assessed. This included heating, particulate filtration, ultraviolet sterilization, and monthly pulse hyperchlorination of water supplied to the BMT unit. The incidence of\n                      <jats:italic>Legionella<\/jats:italic>\n                      infections was assessed on the BMT unit and compared with the frequency elsewhere in the hospital.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00092321_abs6\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were only three cases of\n                      <jats:italic>Legionella<\/jats:italic>\n                      pneumonia among 201 patients undergoing transplantation on a new BMT unit. In contrast, 33 cases of\n                      <jats:italic>Legionella<\/jats:italic>\n                      infections were detected from approximately 150 patients treated on general medical floors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0899823X00092321_abs7\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      A multifaceted approach to decontamination of a hospital water system led to a marked reduction in\n                      <jats:italic>Legionella<\/jats:italic>\n                      infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1086\/646639","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T12:30:04Z","timestamp":1251808204000},"page":"571-575","source":"Crossref","is-referenced-by-count":25,"title":["Prevention of\n                    <i>Legionella<\/i>\n                    Infections in a Bone Marrow Transplant Unit: Multifaceted Approach to Decontamination of a Water System"],"prefix":"10.1017","volume":"14","author":[{"given":"Ursula","family":"Matulonis","sequence":"first","affiliation":[{"name":"Dana Farber Cancer Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig S.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"West Penn Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Shadduck","sequence":"additional","affiliation":[{"name":"West Penn 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