{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T12:11:49Z","timestamp":1776341509753,"version":"3.51.2"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":6363,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[1997,8]]},"abstract":"Abstract<\/jats:title>\n \n Objectives:<\/jats:title>\n We sought to define the prevalence of tuberculin skin test (TST) positivity in a group of newly hospitalized patients, to identify risk factors for positive tests, and to examine the impact of testing on infection control practices.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Unblinded cohort study over 5 days in July 1992.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n A 1,000-bed university-affiliated hospital.<\/jats:p>\n <\/jats:sec>\n \n Patients:<\/jats:title>\n \n All patients admitted (excluding obstetric patients and newborns) were interviewed. Patients without a history of tuberculosis (TB) or a positive TST were offered a TST with\n Candida<\/jats:italic>\n and tetanus controls.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of 346 patients offered the test, 21 (6%) had a prior history of TB or a positive TST, and 36 (10%) declined to participate; 279 of the remaining 289 completed the study. Anergy was demonstrated in 94 (33.7%) of 279 patients. New positive TSTs were identified in 19 (10.3%) of 185 nonanergic patients. Of the 19 TST-positive patients, 6 (32%) had infiltrates on chest radiographs and were evaluated for active TB. One patient was treated empirically for active TB, and five received isoniazid prophylaxis. Risk factors for a new positive TST included age (odds ratio [OR], 1.56 per decade of life;\n P<\/jats:italic>\n =.021), African American race (OR, 4.81;\n P<\/jats:italic>\n =.008), alcohol abuse (OR, 5.53;\n P<\/jats:italic>\n =.005), and peptic ulcer disease (OR, 4.53;\n P<\/jats:italic>\n =.017). Risk factors for anergy included admission to a surgical service (OR, 2.1;\n P<\/jats:italic>\n =.006), current use of steroids (OR, 2.65;\n P<\/jats:italic>\n =.005), and human immunodeficiency virus (HIV) infection (OR, undefined;\n P<\/jats:italic>\n =.034).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Despite a high rate of anergy, routine tuberculin skin testing identified a substantial number of patients with TB infection who might otherwise have gone unrecognized.<\/jats:p>\n <\/jats:sec>","DOI":"10.1086\/647672","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T14:11:02Z","timestamp":1253110262000},"page":"561-565","source":"Crossref","is-referenced-by-count":11,"title":["Tuberculin Skin Testing of Hospitalized Patients"],"prefix":"10.1017","volume":"18","author":[{"given":"Keith F.","family":"Woeltje","sequence":"first","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles M.","family":"Kilo","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Johnson","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathon","family":"Primack","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria J.","family":"Fraser","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700092651_bib012","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0002-9343(97)89457-0","article-title":"Tuberculin skin test reactivity, anergy, and HIV infection in hospitalized patients","volume":"100","author":"Janis","year":"1996","journal-title":"Am J Med"},{"key":"S0195941700092651_bib005","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480190074035"},{"key":"S0195941700092651_bib004","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1164\/ajrccm\/144.4.741","article-title":"The U-shaped curve of concern","volume":"144","author":"Reichman","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"S0195941700092651_bib018","first-page":"59","article-title":"Selection of skin test antigens to evaluate PPD anergy","volume":"41","author":"Wright","year":"1995","journal-title":"J Fam Pract"},{"key":"S0195941700092651_bib002","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/146.6.1623"},{"key":"S0195941700092651_bib011","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1001\/archsurg.1995.01430110081015","article-title":"Tuberculin screening of trauma admissions at a university hospital. 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