{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:55:57Z","timestamp":1774565757005,"version":"3.50.1"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":6210,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0195941700000114_abs1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To analyze risk factors for, and the role of methicillin resistance in, mortality in\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      bacteremia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0195941700000114_abs2\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>Nested case-control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0195941700000114_abs3\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>\n                      General teaching hospital with a high prevalence of methicillin-resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MRSA) strains, in S\u00e3o Paulo, Brazil.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0195941700000114_abs4\">\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>\n                      136 patients over 14 years old with documented\n                      <jats:italic>S aureus<\/jats:italic>\n                      bacteremia. Those who died were compared with those who survived at least 14 days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0195941700000114_abs5\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mortality within 14 days of bacteremia was 39% (53\/136). Mean age was 47 years. Hospital-acquired bacteremia represented 86% (117\/136) of episodes. In 26% (35\/136), infection was related to an intravascular catheter and in 13% (17\/136) to the respiratory tract. Septic shock occurred in 22% (30\/136) of cases. MRSA was isolated in 66% (90\/136). Multivariate analysis identified three variables that were significantly and independently associated with mortality: site of entry (lung, odds ratio [OR], 17.0; unknown, OR, 12.3; others, OR, 6.6); occurrence of shock (OR, 8.9), and resistance of\n                      <jats:italic>S aureus<\/jats:italic>\n                      to methicillin (OR, 4.2).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0195941700000114_abs6\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Our study shows that\n                      <jats:italic>S aureus<\/jats:italic>\n                      bacteremia has a high mortality, especially when the lung is the source of infection and when shock develops; resistance to methicillin may be another risk factor for poor outcome.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1086\/647704","type":"journal-article","created":{"date-parts":[[2009,9,16]],"date-time":"2009-09-16T14:13:07Z","timestamp":1253110387000},"page":"32-37","source":"Crossref","is-referenced-by-count":121,"title":["Risk Factors for Mortality in\n                    <i>Staphylococcus aureus<\/i>\n                    Bacteremia"],"prefix":"10.1017","volume":"19","author":[{"given":"Lucieni Oliveira","family":"Conterno","sequence":"first","affiliation":[{"name":"Infectious Diseases Division of Marilia Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio Barsanti","family":"Wey","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases of S\u00e3o Paulo Federal Medical School\u2013UNIFESP"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adauto","family":"Castelo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases of S\u00e3o Paulo Federal Medical School\u2013UNIFESP"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700000114_bib001","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/25.suppl_C.115"},{"key":"S0195941700000114_bib022","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM198709103171102","article-title":"Effect of high-dose glucorticoid therapy on mortality in patients with clinical signs of systemic sepsis","volume":"317","author":"Hinshaw","year":"1987","journal-title":"N Engl J Med"},{"key":"S0195941700000114_bib020","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/15.6.991"},{"key":"S0195941700000114_bib023","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/00365548709117196","article-title":"Bacteremic Staphylococcus aureus pneumonia","volume":"19","author":"Watanakunakorn","year":"1987","journal-title":"Scand J Infect Dis"},{"key":"S0195941700000114_bib009","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0002-9343(93)90063-U","article-title":"Methicillin-resistant Staphylococcus aureus: a consensus review of microbiology, pathogenesis, and epidemiology with implications for prevention and management","volume":"94","author":"Mulligan","year":"1993","journal-title":"Am J Med"},{"key":"S0195941700000114_bib016","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-6553(85)80011-0"},{"key":"S0195941700000114_bib017","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1001\/archsurg.1989.01410120106020","article-title":"What's in a name? 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