{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:21:38Z","timestamp":1773858098899,"version":"3.50.1"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":1858,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:sec id=\"S0195941700038078_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To investigate the annual rate of tuberculosis (TB) infection among newly employed nurses using both tuberculin skin test (TST) and QuantiFERON-TB Gold (QFT-G; Cellestis Limited) assay.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700038078_abs2\"><jats:title>Design.<\/jats:title><jats:p>A prospective cohort study involving newly employed nurses.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700038078_abs3\"><jats:title>Setting.<\/jats:title><jats:p>A tertiary care university hospital in South Korea.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700038078_abs4\"><jats:title>Methods.<\/jats:title><jats:p>All participants (<jats:italic>n<\/jats:italic> = 196) were tested with the TST and QFT-G assay at baseline. After 1 year, the TST and QFT-G assay were reperformed for subjects who had negative TST results at baseline and for all subjects, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700038078_abs5\"><jats:title>Results.<\/jats:title><jats:p>The baseline TST and QFT-G assays were positive for 101 subjects (51.5%) and 28 subjects (14.3%), respectively; 22 subjects (11.2%) had positive results of both tests. Although the overall between-test agreement was 54.9% (\u03ba = 0.151 [95% confidence interval, 0.047\u20130.245]), agreement improved to 78.5% (\u03ba = 0.462 [95% confidence interval, 0.007\u20130.917]) for subjects who had not received bacille Calmette-Gu\u00e9rin vaccination. After 1 year, the TST yielded positive results for 16 (21.3%) of 75 nurses with negative baseline results, and the QFT-G assay yielded positive results for 21 (14.4%) of 146 subjects with negative baseline Results. Collectively, 5 subjects (3.0%) experienced conversion to positive results with both tests, and 32 subjects (18.9%) experienced conversion to positive results with one of the tests. Neither the employing hospital department nor exposure to patients with TB affected test conversion status.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700038078_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>The poor overall agreement between TST and QFT-G results may have been caused by the confounding effect of bacille Calmette-Gu\u00e9rin vaccination. The annual risk of TB infection among newly employed nurses was at least 3% on the basis of results of both the TST and QFT-G test. Stricter preventive strategies against TB spread should be implemented in our hospital.<\/jats:p><\/jats:sec>","DOI":"10.1086\/648082","type":"journal-article","created":{"date-parts":[[2009,10,22]],"date-time":"2009-10-22T21:12:51Z","timestamp":1256245971000},"page":"1218-1222","source":"Crossref","is-referenced-by-count":35,"title":["Annual Incidence of Latent Tuberculosis Infection among Newly Employed Nurses at a Tertiary Care University Hospital"],"prefix":"10.1017","volume":"30","author":[{"given":"Kwangha","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyoung","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Ran","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Min","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeon-Mok","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Do","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Soon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Hee","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Sun","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700038078_ref010","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5419.1520"},{"key":"S0195941700038078_ref024","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-232OC"},{"key":"S0195941700038078_ref008","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/145.3.621"},{"key":"S0195941700038078_ref030","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-472OC"},{"key":"S0195941700038078_ref012","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00006"},{"key":"S0195941700038078_ref028","first-page":"1","article-title":"Guidelines for preventing the transmission of Mycobacterium tuberculosis in health-care settings, 2005","volume":"54","author":"Jensen","year":"2005","journal-title":"MMWR Recomm Rep"},{"key":"S0195941700038078_ref014","first-page":"27","article-title":"The seventh nationwide tuberculosis prevalence survey in Korea, 1995","volume":"2","author":"Hong","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"S0195941700038078_ref006","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.9.804"},{"key":"S0195941700038078_ref016","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.22.2756"},{"key":"S0195941700038078_ref009","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.1.214-220.2000"},{"key":"S0195941700038078_ref004","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.1.9801120"},{"key":"S0195941700038078_ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-007-0212-1"},{"key":"S0195941700038078_ref032","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200811-1704OC"},{"key":"S0195941700038078_ref026","first-page":"49","article-title":"Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States","volume":"54","author":"Mazurek","year":"2005","journal-title":"MMWR Recomm Rep"},{"key":"S0195941700038078_ref025","doi-asserted-by":"publisher","DOI":"10.1086\/590262"},{"key":"S0195941700038078_ref031","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0001850"},{"key":"S0195941700038078_ref027","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040208"},{"key":"S0195941700038078_ref007","first-page":"15","article-title":"Guidelines for using the QuantiFERON-TB test for diagnosing latent Mycobacterium tuberculosis infection. 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