{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:57:27Z","timestamp":1761418647963},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":1827,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec id=\"S0195941700028459_abs1\"><jats:title>Background.<\/jats:title><jats:p>Methicillin-resistant<jats:italic>Staphylococcus aureus<\/jats:italic>(MRSA) is an emerging concern in infectious disease practice. Although MRSA infections occur in a wide variety of anatomic sites, the majority of studies considering the risk factors for methicillin resistance among<jats:italic>S. aureus<\/jats:italic>infections have focused on MRSA bacteremia.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700028459_abs2\"><jats:title>Objective.<\/jats:title><jats:p>To describe risk factors associated with methicillin resistance among<jats:italic>S. aureus<\/jats:italic>infections at different anatomic sites.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700028459_abs3\"><jats:title>Methods.<\/jats:title><jats:p>We collected information on the demographic and clinical characteristics of patients examined at the Atlanta Veterans Affairs Medical Center with<jats:italic>S. aureus<\/jats:italic>infections during the period from June 2007 through May 2008. We used multivariate logistic regression to describe factors significantly associated with methicillin resistance.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700028459_abs4\"><jats:title>Results.<\/jats:title><jats:p>There were 568 cases of<jats:italic>S. aureus<\/jats:italic>infection among 528 patients. We identified 352 cases (62%) of MRSA infection and 216 cases (38%) of methicillin-sensitive<jats:italic>S. aureus<\/jats:italic>infection. The adjusted odds of methicillin resistance were higher among infections that occurred among patients who had a prior history of MRSA infection (odds ratio [OR], 3.9 [95% confidence interval {CI}, 2.3\u20136.4]) or resided in a long-term care facility during the past 12 months (OR, 2.0 [95% CI, 1.0-4.0]) but were lower for infections that occurred among patients who had undergone a biopsy procedure during the past 12 months (OR, 0.7 [95% CI, 0.6-0.9]). Most cases of infection were community-onset infections (523 [92%] of 568 cases), and about one-half (278 [49%]) were not healthcare associated.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700028459_abs5\"><jats:title>Conclusions.<\/jats:title><jats:p>Compared with previous studies of methicillin resistance among patients with<jats:italic>S. aureus<\/jats:italic>bacteremia, we found similar factors to be associated with methicillin resistance among<jats:italic>S. aureus<\/jats:italic>isolates recovered from more diverse anatomic sites of infection. Of note, nearly one-half of our cases of MRSA infection were not healthcare associated.<\/jats:p><\/jats:sec>","DOI":"10.1086\/649017","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T21:18:37Z","timestamp":1259097517000},"page":"36-41","source":"Crossref","is-referenced-by-count":5,"title":["Risk Factors Associated with Methicillin Resistance among<i>Staphylococcus aureus<\/i>Infections in Veterans"],"prefix":"10.1017","volume":"31","author":[{"given":"Natalie L.","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick 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