{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:59:39Z","timestamp":1775077179647,"version":"3.50.1"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":1554,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec id=\"S0195941700039114_abs1\">\n\t    <jats:title>Objective.<\/jats:title>\n\t    <jats:p>To determine whether an earlier determination of staphylococcal species and their antibiotic susceptibility decreases unnecessary antistaphylococcal treatment and\/or facilitates earlier appropriate treatment.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0195941700039114_abs2\">\n\t    <jats:title>Methods.<\/jats:title>\n\t    <jats:p>We used the Xpert MRSA\/SA BC system (Cepheid) for immediate determination of species and their drug susceptibility in patients whose blood cultures revealed gram-positive cocci in clusters. We compared the treatment of patients whose physicians received early notification of these results (group 1) with the treatment of patients in a historical cohort with delayed reporting after traditional microbiological studies (group 2). Outcomes were analyzed according to whether blood culture was positive for <jats:italic>Staphylococcus<\/jats:italic> species other than <jats:italic>S. aureus,<\/jats:italic> methicillin-susceptible <jats:italic>S. aureus<\/jats:italic> (MSSA), or methicillin-resistant <jats:italic>S. aureus<\/jats:italic> (MRSA) and whether the drugs used were appropriate for methicillin-susceptible or methicillin-resistant staphylococci (hereafter referred to as \u201cMSS drug\u201d or \u201cMRS drug\u201d therapy, respectively).<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0195941700039114_abs3\">\n\t    <jats:title>Results.<\/jats:title>\n\t    <jats:p>There were 44 (76%) of 58 patients with bacteremia due to <jats:italic>Staphylococcus<\/jats:italic> species other than <jats:italic>S. aureus<\/jats:italic> in group 1 and 58 (55%) of 106 patients with bacteremia due to <jats:italic>Staphylococcus<\/jats:italic> species other than <jats:italic>S. aureus<\/jats:italic> in group 2 who received no antistaphylococcal antibiotics (<jats:italic>P<\/jats:italic> &lt;.01). Five (6%) of 89 patients in group 1 and 31 (25%) of 123 patients in group 2 received 0-168 hours (0-7 days) of MRS drug therapy (<jats:italic>P<\/jats:italic> &lt; .01). Among patients with MSSA bacteremia, the mean time to initiation of appropriate therapy was 5.2 hours in group 1 and 49.8 hours in group 2 (<jats:italic>P<\/jats:italic> &lt; = .007). Excluding patients who received MRS drug therapy for unrelated conditions, the mean duration of treatment was 19.7 hours in group 1 and 80.7 hours in group 2 (<jats:italic>P<\/jats:italic> = .003). Six (50%) of the 12 patients in group 1 and 39 (81%) of the 48 patients in group 2 received MRS drug therapy for MSSA bacteremia (<jats:italic>P<\/jats:italic> = .025). Time to initiation of therapy for MRSA bacteremia did not differ between groups.<\/jats:p>\n\t  <\/jats:sec>\n\t  <jats:sec id=\"S0195941700039114_abs4\">\n\t    <jats:title>Conclusions.<\/jats:title>\n\t    <jats:p>The use of an assay with rapid results reduced the use of antistaphylococcal therapy among patients who did not have <jats:italic>S. aureus<\/jats:italic> bacteremia; it also decreased the use of MRS drug therapy and led to earlier appropriate therapy among patients with MSSA bacteremia.<\/jats:p>\n\t  <\/jats:sec>","DOI":"10.1086\/656248","type":"journal-article","created":{"date-parts":[[2010,8,23]],"date-time":"2010-08-23T20:48:34Z","timestamp":1282596514000},"page":"1043-1048","source":"Crossref","is-referenced-by-count":81,"title":["Impact of an Assay That Enables Rapid Determination of <i>Staphylococcus<\/i> Species and Their Drug Susceptibility on the Treatment of Patients with Positive Blood Culture Results"],"prefix":"10.1017","volume":"31","author":[{"given":"Mark","family":"Parta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Goebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimmy","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Matloobi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Stager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Musher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700039114_manual_ref-4","volume-title":"Instruction manual","year":"2008"},{"key":"S0195941700039114_manual_ref-9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jac\/dkh366","article-title":"Outcome of inappropriate initial antimicrobial treatment in patients with methicillin-resistant Staphylococcus aureus bacteraemia","volume":"54","author":"Kim","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"S0195941700039114_manual_ref-8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10096-007-0272-x","article-title":"Predictors of mortality in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia: the role of empiric antibiotic therapy","volume":"26","author":"Gomez","year":"2007","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"S0195941700039114_manual_ref-13","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1086\/513203","article-title":"The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus","volume":"44","author":"Tenover","year":"2007","journal-title":"Clin Infect Dis"},{"key":"S0195941700039114_manual_ref-6","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00700-07"},{"key":"S0195941700039114_manual_ref-2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.amjsurg.2009.07.010","article-title":"Implementation of a methicillin-resistant Staphylococcus aureus (MRSA) prevention bundle results in decreased MRSA surgical site infections","volume":"198","author":"Awad","year":"2009","journal-title":"Am J Surg"},{"key":"S0195941700039114_manual_ref-12","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00407-09"},{"key":"S0195941700039114_manual_ref-14","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/jac\/dkn246","article-title":"Vancomycin MICs did not creep in Staphylococcus aureus isolates from 2002 to 2006 in a setting with low vancomycin usage","volume":"62","author":"Alos","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"S0195941700039114_manual_ref-7","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl006"},{"key":"S0195941700039114_manual_ref-3","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00351-09"},{"key":"S0195941700039114_manual_ref-10","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1097\/01.CCM.0000227655.41566.3E","article-title":"Methicillin-resistant Staphylococcus aureus sterile-site infection: the importance of appropriate initial antimicrobial treatment","volume":"34","author":"Schramm","year":"2006","journal-title":"Crit Care Med"},{"key":"S0195941700039114_manual_ref-5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/01.md.0000091184.93122.09","article-title":"Staphylococcus aureus bacteremia: recurrence and the impact of antibiotic treatment in a prospective multicenter study","volume":"82","author":"Chang","year":"2003","journal-title":"Medicine (Baltimore)"},{"key":"S0195941700039114_manual_ref-11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1469-0691.2005.01294.x","article-title":"Outcome of inappropriate empirical antibiotic therapy in patients with Staphylococcus aureus bacteraemia: analytical strategy using propensity scores","volume":"12","author":"Kim","year":"2006","journal-title":"Clin Microbiol Infect"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700039114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T07:36:11Z","timestamp":1750491371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700039114\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":13,"aliases":["10.1086\/653027"],"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0195941700039114"],"URL":"https:\/\/doi.org\/10.1086\/656248","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}