{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:35:03Z","timestamp":1785929703436,"version":"3.56.0"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":1493,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec id=\"S0195941700039369_abs1\"><jats:title>Background and Objective.<\/jats:title><jats:p>Carbapenem resistance among Enterobacteriaceae is of concern because of increasing prevalence and limited therapeutic options. Limited research has been focused on understanding ertapenem resistance as a more sensitive marker for resistance to other carbapenems. We sought to determine risk factors for acquisition of ertapenem-resistant, meropenem-susceptible, or intermediate Enterobacteriaceae and to assess associated patient outcomes.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039369_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective case-control study among adult hospitalized inpatients.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039369_abs3\"><jats:title>Setting.<\/jats:title><jats:p>A 902-bed quaternary care urban hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039369_abs4\"><jats:title>Results.<\/jats:title><jats:p>Sixty-two cases of ertapenem-resistant Enterobacteriaceae were identified from March 14, 2006, through October 31, 2007, and 62 unmatched control patients were randomly selected from other inpatients with cultures positive for ertapenem-susceptible Enterobacteriaceae. Thirty-seven (60%) of case patient isolates were <jats:italic>Enterobacter cloacae<\/jats:italic>, 20 (32%) were <jats:italic>Klebsiella pneumoniae<\/jats:italic>, and 5 (8%) were other species of Enterobacteriaceae. Risk factors for ertapenem-resistant Enterobacteriaceae infection included intensive care unit stay (odds ratio [OR], 4.6 [95% confidence interval {CI}, 2.0\u201310.3]), vancomycin-resistant <jats:italic>Enterococcus<\/jats:italic> colonization (OR, 7.1 [95% CI, 2.4\u201321.4]), prior central venous catheter use (OR, 10.0 [95% CI, 3.0\u201333.1]), prior receipt of mechanical ventilation (OR, 5.8 [95% CI, 2.1\u201316.2]), exposure to any antibiotic during the 30 days prior to a positive culture result (OR, 18.5 [95% CI, 4.9\u201369.9]), use of a \u03b2-lactam during the 30 days prior to a positive culture result (OR, 6.9 [95% CI, 3.0\u201316.0], and use of a carbapenem during the 30 days prior to a positive culture result (OR, 18.2 [95% CI, 2.6\u2013130.0]). For the 62 case patients, 30-day outcomes from the time of positive culture result were 24 discharges (39%), 10 deaths (16%), and 28 continued hospitalizations (44%). The final end point of the hospitalization was discharge for 44 patients (71%) and death for 18 patients (29%).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039369_abs5\"><jats:title>Conclusions.<\/jats:title><jats:p>Ertapenem-resistant Enterobacteriaceae are important nosocomial pathogens. Multiple mechanisms of resistance maybe in operation. Additional study of ertapenem resistance is needed.<\/jats:p><\/jats:sec>","DOI":"10.1086\/657138","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T20:33:40Z","timestamp":1288298020000},"page":"1242-1249","source":"Crossref","is-referenced-by-count":36,"title":["Ertapenem-Resistant Enterobacteriaceae Risk Factors for Acquisition and Outcomes"],"prefix":"10.1017","volume":"31","author":[{"given":"E. 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