{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:21:23Z","timestamp":1788225683148,"version":"build-2803163510"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":1493,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec id=\"S0195941700039357_abs1\"><jats:title>Objectives.<\/jats:title><jats:p>To describe vaporized hydrogen peroxide (VHP) as an adjuvant in the control of multidrug-resistant (MDR)<jats:italic>Acinetobacter baumannii<\/jats:italic>infection in a long-term acute care hospital (LTACH) and to describe the risk factors for acquisition of MDR<jats:italic>A. baumannii<\/jats:italic>infection in the LTACH population.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039357_abs2\"><jats:title>Design.<\/jats:title><jats:p>Outbreak investigation, case-control study, and before-after intervention trial.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039357_abs3\"><jats:title>Setting.<\/jats:title><jats:p>A 54-bed LTACH affiliated with a tertiary care center in northeastern Ohio.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039357_abs4\"><jats:title>Methods.<\/jats:title><jats:p>Investigation of outbreak with clinical and environmental cultures, antimicrobial susceptibility testing, polymerase chain reaction assay of repetitive chromosomal elements to type strains, and case-control study; and intervention consisting of comprehensive infection control measures and VHP environmental decontamination.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039357_abs5\"><jats:title>Results.<\/jats:title><jats:p>Thirteen patients infected or colonized with MDR<jats:italic>A. baumannii<\/jats:italic>were identified from January 2008 through June 2008. By susceptibility testing, 10 (77%) of the 13 isolates were carbapenem-resistant. MDR<jats:italic>A. baumannii<\/jats:italic>was found in wound samples, blood, sputum, and urine. Wounds were identified as a risk factor for MDR<jats:italic>A. baumannii<\/jats:italic>colonization. Ventilator-associated pneumonia was the most common clinical syndrome caused by the pathogen, and the associated mortality was 14% (2 of the 13 case patients died). MDR<jats:italic>A. baumannii<\/jats:italic>was found in 8 of 93 environmental samples, including patient rooms and a wound care cart; environmental and clinical cultures were genetically related. Environmental cultures were negative immediately after VHP decontamination and both 24 hours and 1 week after VHP decontamination. Nosocomial acquisition of the pathogen in the LTACH ceased after VHP Intervention. When patients colonized with MDR<jats:italic>A. baumannii<\/jats:italic>reoccupied rooms, environmental contamination recurred.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039357_abs6\"><jats:title>Conclusion.<\/jats:title><jats:p>Environmental decontamination using VHP combined with comprehensive infection control measures interrupted nosocomial transmission of MDR<jats:italic>A. baumannii<\/jats:italic>in an LTACH. The application of this novel approach to halt the transmission of MDR<jats:italic>A. baumannii<\/jats:italic>warrants further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1086\/657139","type":"journal-article","created":{"date-parts":[[2010,10,25]],"date-time":"2010-10-25T20:42:36Z","timestamp":1288039356000},"page":"1236-1241","source":"Crossref","is-referenced-by-count":55,"title":["Use of Vaporized Hydrogen Peroxide Decontamination during an Outbreak of Multidrug-Resistant<i>Acinetobacter baumannii<\/i>Infection at a Long-Term Acute Care Hospital"],"prefix":"10.1017","volume":"31","author":[{"given":"Amy","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Beltramini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Jakubowycz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Dimick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Bonomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Salata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700039357_ref019","unstructured":"Medicare Payment Advisory Commission. 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