{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T07:03:39Z","timestamp":1769238219688,"version":"3.49.0"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":1493,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec id=\"S0195941700039412_abs1\"><jats:title>Objective.<\/jats:title><jats:p>The Center for Disease Control and Prevention recommends the use of QuantiFERON TB Gold test (QFTG; Cellestis) in all situations where the tuberculin skin test (TST) is used. In November 2007, our institution replaced its screening-tool TST with the QFTG in-tube assay (QFT-GIT) for annual screening of latent tuberculosis infection among healthcare workers (HCWs). This study evaluated the effectiveness of QFT-GIT test as screening tool in HCWs at our institution.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039412_abs2\"><jats:title>Methods.<\/jats:title><jats:p>This retrospective study reviewed medical records of all HCWs who underwent screening with QFT-GIT from January 2008 through December 2008.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039412_abs3\"><jats:title>Results.<\/jats:title><jats:p>Among the 6,530 HCWs screened with QFT-GIT from January through December 2008, 287 had a positive test result. Of the 287, 123 had positive TST results in the past, meaning that 164 HCWs had newly diagnosed latent tuberculosis infection by QFT-GIT. Of the 164 HCWs, 135 were retested by QFT-GIT and were simultaneously tested with TST within 4 weeks after the initial QFT-GIT. Of these 135 HCWs, 66 reverted to negative results and results remained positive for 69 with QFT-GIT. Only 2 HCWs had a positive TST result.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700039412_abs4\"><jats:title>Conclusions.<\/jats:title><jats:p>The disagreement between QFT-GIT and TST results and the high reversion rate with QFT-GIT raise concerns about the effectiveness of QFT-GIT as a sole screening test in HCWs.<\/jats:p><\/jats:sec>","DOI":"10.1086\/657336","type":"journal-article","created":{"date-parts":[[2010,10,27]],"date-time":"2010-10-27T17:55:14Z","timestamp":1288202114000},"page":"1279-1285","source":"Crossref","is-referenced-by-count":36,"title":["Questionable Effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a Screening Tool in Healthcare Workers"],"prefix":"10.1017","volume":"31","author":[{"given":"Sumanth","family":"Gandra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya","family":"Somaraju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Wilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Feigenbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700039412_ref001","doi-asserted-by":"publisher","DOI":"10.1086\/314075"},{"key":"S0195941700039412_ref003","unstructured":"Centers for Disease Control and Prevention. Tuberculosis (TB). September 29, 2010. http:\/\/www.cdc.gov\/tb\/publications\/factsheets\/testing\/QFT.htm\/. Accessed January 29, 2010."},{"key":"S0195941700039412_ref005","first-page":"49","article-title":"Division of Tuberculosis Elimination, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention (CDC). Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculosis infection, United States","volume":"54","author":"Mazurek","year":"2005","journal-title":"MMWR Recomm Rep"},{"key":"S0195941700039412_ref011","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040208"},{"key":"S0195941700039412_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02742-2"},{"key":"S0195941700039412_ref007","doi-asserted-by":"publisher","DOI":"10.1086\/504358"},{"key":"S0195941700039412_ref004","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00006"},{"key":"S0195941700039412_ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-007-0212-1"},{"key":"S0195941700039412_ref009","unstructured":"Diagnosis of Tuberculosis Infection and Disease. Canadian tuberculosis standards. 6th ed. 2007:83\u201384."},{"key":"S0195941700039412_ref010","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00398-07"},{"key":"S0195941700039412_ref012","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.524"},{"key":"S0195941700039412_ref013","first-page":"16","article-title":"Interferon-gamma release assays and TB screening in high-income countries: a cost-effectiveness analysis","volume":"11","author":"Oxlade","year":"2007","journal-title":"Int J Tuberc Lung Dis"},{"key":"S0195941700039412_ref008","doi-asserted-by":"publisher","DOI":"10.1086\/590262"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700039412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T16:47:16Z","timestamp":1556383636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700039412\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["S0195941700039412"],"URL":"https:\/\/doi.org\/10.1086\/657336","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}