{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:26:53Z","timestamp":1776702413683,"version":"3.51.2"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":945,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:sec id=\"S0195941700031015_abs1\"><jats:title>Objective.<\/jats:title><jats:p>Bloodstream infections due to methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) have been associated with significant risk of in-hospital mortality. The acute physiology and chronic health evaluation (APACHE) II score was developed and validated for use among intensive care unit (ICU) patients, but its utility among non-ICU patients is unknown. The aim of this study was to determine the ability of APACHE II to predict death at multiple time points among ICU and non-ICU patients with MRSA bacteremia.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031015_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031015_abs3\"><jats:title>Participants.<\/jats:title><jats:p>Secondary analysis of data from 200 patients with MRSA bacteremia at 2 hospitals.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031015_abs4\"><jats:title>Methods.<\/jats:title><jats:p>Logistic regression models were constructed to predict overall in-hospital mortality and mortality at 48 hours, 7 days, 14 days, and 30 days using APACHE II scores separately in ICU and non-ICU patients. The performance of APACHE II scores was compared with age adjustment alone among all patients. Discriminatory ability was assessed using the c-statistic and was compared at each time point using X<jats:sup>2<\/jats:sup> tests. Model calibration was assessed using the Hosmer-Lemeshow goodness-of-fit test.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031015_abs5\"><jats:title>Results.<\/jats:title><jats:p>APACHE II was a significant predictor of death at all time points in both ICU and non-ICU patients. Discrimination was high in all models, with c-statistics ranging from 0.72 to 0.84, and was similar between ICU and non-ICU patients at all time points. APACHE II scores significantly improved the prediction of overall and 48-hour mortality compared with age adjustment alone.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031015_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>The APACHE II score may be a valid tool to control for confounding or for the prediction of death among ICU and non-ICU patients with MRSA bacteremia.<\/jats:p><\/jats:sec>","DOI":"10.1086\/665731","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T18:50:24Z","timestamp":1336157424000},"page":"558-564","source":"Crossref","is-referenced-by-count":24,"title":["The Utility of Acute Physiology and Chronic Health Evaluation II Scores for Prediction of Mortality among Intensive Care Unit (ICU) and Non-ICU Patients with Methicillin-Resistant <i>Staphylococcus aureus<\/i> 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