{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:42:32Z","timestamp":1780378952547,"version":"3.54.1"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":884,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec id=\"S0195941700031295_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To determine the proportion of methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) detections identified by nasal swabbing using agar culture in comparison with multiple body site testing using agar and nutrient broth culture.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031295_abs2\"><jats:title>Design.<\/jats:title><jats:p>Cross-sectional study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031295_abs3\"><jats:title>Patients.<\/jats:title><jats:p>Adult patients admitted to 36 general specialty wards of 2 large hospitals in Scotland.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031295_abs4\"><jats:title>Methods.<\/jats:title><jats:p>Patients were screened for MRSA via multiple body site swabs (nasal, throat, axillary, perineal, and wound\/invasive device sites) cultured individually on chromogenic agar and pooled in nutrient broth. Combined results from all sites and cultures provided a gold-standard estimate of true MRSA prevalence.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031295_abs5\"><jats:title>Results.<\/jats:title><jats:p>This study found that nasal screening performed better than throat, axillary, or perineal screening but at best identified only 66% of true MRSA carriers against the gold standard at an overall prevalence of 2.9%. Axillary screening performed least well. Combining nasal and perineal swabs gave the best 2-site combination (82%). When combined with realistic screening compliance rates of 80%\u201390%, nasal swabbing alone probably detects just over half of true colonization in practice. Swabbing of clinically relevant sites (wounds, indwelling devices, etc) is important for a small but high-prevalence group.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031295_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>Nasal swabbing is the standard method in many locations for MRSA screening. Its diagnostic efficiency in practice appears to be limited, however, and the resource implications of multiple body site screening have to be balanced against a potential clinical benefit whose magnitude and nature remains unclear.<\/jats:p><\/jats:sec>","DOI":"10.1086\/666639","type":"journal-article","created":{"date-parts":[[2012,7,3]],"date-time":"2012-07-03T12:49:39Z","timestamp":1341319779000},"page":"803-808","source":"Crossref","is-referenced-by-count":53,"title":["Nasal Swab Screening for Methicillin-Resistant <i>Staphylococcus aureus<\/i>\u2014How Well Does It Perform? A Cross-Sectional Study"],"prefix":"10.1017","volume":"33","author":[{"given":"Ann","family":"Matheson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Christie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Traiani","family":"Stari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Kavanagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M.","family":"Gould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Masterton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqui S.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700031295_ref015","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0869-3"},{"key":"S0195941700031295_ref021","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1153-1"},{"key":"S0195941700031295_ref017","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02121-06"},{"key":"S0195941700031295_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.09.001"},{"key":"S0195941700031295_ref006","doi-asserted-by":"publisher","DOI":"10.1086\/520743"},{"key":"S0195941700031295_ref013","volume-title":"The Clinical and Cost Effectiveness of Screening for Meticillin-Resistant Staphylococcus aureus (MRSA)","author":"Ritchie","year":"2007"},{"key":"S0195941700031295_ref014","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-008-0602-7"},{"key":"S0195941700031295_ref022","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00315-07"},{"key":"S0195941700031295_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.07.011"},{"key":"S0195941700031295_ref023","volume-title":"Adults with Incapacity (Scotland) Act 2000","year":"2000"},{"key":"S0195941700031295_ref030","unstructured":"Health Protection Scotland. 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Final Report Volume 1: An Investigation of the Clinical Effectiveness of MRSA Screening. Glasgow: Health Protection Scotland, 2009. http:\/\/www.documents.hps.scot.nhs.uk\/hai\/mrsa-screening\/pathfinder-programme\/mrsa-pathfinder-voll-2011-02-23.pdf. Accessed May 1, 2012."},{"key":"S0195941700031295_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-6701(97)90071-2"},{"key":"S0195941700031295_ref018","doi-asserted-by":"publisher","DOI":"10.1086\/596045"},{"key":"S0195941700031295_ref019","doi-asserted-by":"publisher","DOI":"10.1086\/652778"},{"key":"S0195941700031295_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.06.005"},{"key":"S0195941700031295_ref025","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2005.01.032"},{"key":"S0195941700031295_ref028","doi-asserted-by":"publisher","DOI":"10.1086\/652524"},{"key":"S0195941700031295_ref029","unstructured":"Health Protection Scotland. 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