{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T19:18:21Z","timestamp":1774725501916,"version":"3.50.1"},"reference-count":8,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":853,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec id=\"S0195941700031453_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To develop a modified surveillance definition of central line-associated bloodstream infection (mCLABSI) specific for our population of patients with hematologic malignancies to better support ongoing improvement efforts at our hospital.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031453_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031453_abs3\"><jats:title>Patients.<\/jats:title><jats:p>Hematologic malignancies population in a 1,200-bed tertiary care hospital on a 22-bed bone marrow transplant (BMT) unit and a 22-bed leukemia unit.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031453_abs4\"><jats:title>Methods.<\/jats:title><jats:p>An mCLABSI definition was developed, and pathogens and rates were compared against those determined using the National Healthcare Safety Network (NHSN) definition.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031453_abs5\"><jats:title>Results.<\/jats:title><jats:p>By the NHSN definition the CLABSI rate on the BMT unit was 6.0 per 1,000 central line-days, and by the mCLABSI definition the rate was 2.0 per 1,000 line-days (<jats:italic>P<\/jats:italic> &lt; .001). On the leukemia unit, the NHSN CLABSI rate was 14.4 per 1,000 line-days, and the mCLABSI rate was 8.2 per 1,000 line-days (<jats:italic>P<\/jats:italic> = .009). The top 3 CLABSI pathogens by the NHSN definition were <jats:italic>Enterococcus<\/jats:italic> species, <jats:italic>Klebsiella<\/jats:italic> species, and <jats:italic>Escherichia coli<\/jats:italic>. The top 3 CLABSI pathogens by the mCLABSI definition were coagulase-negative <jats:italic>Staphylococcus<\/jats:italic> (CONS), <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, and <jats:italic>Staphylococcus aureus<\/jats:italic>. The difference in the incidence of CONS as a cause of CLABSI under the 2 definitions was statistically significant (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031453_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>A modified surveillance definition of CLABSI was associated with an increase in the identification of staphylococci as the cause of CLABSIs, as opposed to enteric pathogens, and a decrease in CLABSI rates.<\/jats:p><\/jats:sec>","DOI":"10.1086\/667380","type":"journal-article","created":{"date-parts":[[2012,8,6]],"date-time":"2012-08-06T15:04:23Z","timestamp":1344265463000},"page":"865-868","source":"Crossref","is-referenced-by-count":26,"title":["Development of a Modified Surveillance Definition of Central Line\u2013Associated Bloodstream Infections for Patients with Hematologic Malignancies"],"prefix":"10.1017","volume":"33","author":[{"given":"Megan J.","family":"DiGiorgio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Fatica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Oden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Bolwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikkael","family":"Sekeres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Kalaycio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patti","family":"Akins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Shane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Bako","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven M.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700031453_ref008","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1637"},{"key":"S0195941700031453_ref007","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir138"},{"key":"S0195941700031453_ref004","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.112"},{"key":"S0195941700031453_ref005","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir200"},{"key":"S0195941700031453_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2008.03.002"},{"key":"S0195941700031453_ref003","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir073"},{"key":"S0195941700031453_ref006","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir523"},{"key":"S0195941700031453_ref002","doi-asserted-by":"publisher","DOI":"10.1086\/340402"}],"container-title":["Infection Control &amp; Hospital Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0195941700031453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T18:58:24Z","timestamp":1556132304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0195941700031453\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":8,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0195941700031453"],"URL":"https:\/\/doi.org\/10.1086\/667380","relation":{},"ISSN":["0899-823X","1559-6834"],"issn-type":[{"value":"0899-823X","type":"print"},{"value":"1559-6834","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}