{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:47:42Z","timestamp":1781585262179,"version":"3.54.5"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":762,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect Control Hosp Epidemiol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec id=\"S0195941700050505_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To determine whether transfer from a long-term care facility (LTCF) is a risk factor for colonization with <jats:italic>Klebsiella pneumoniae<\/jats:italic> carbapenemase (KPC)\u2013producing <jats:italic>Enterobacteriaceae<\/jats:italic> upon acute care hospital admission.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050505_abs2\"><jats:title>Design.<\/jats:title><jats:p>Microbiologic survey and nested case-control study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050505_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Four hospitals in a metropolitan area (Chicago) with an early KPC epidemic.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050505_abs4\"><jats:title>Patients.<\/jats:title><jats:p>Hospitalized adults.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050505_abs5\"><jats:title>Methods.<\/jats:title><jats:p>Patients transferred from LTCFs were matched 1 : 1 to patients admitted from the community by age (\u00b1 10 years), admitting clinical service, and admission date (\u00b1 2 weeks). Rectal swab specimens were collected within 3 days after admission and tested for KPC-producing <jats:italic>Enterobacteriaceae<\/jats:italic>. Demographic and clinical information was extracted from medical records.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050505_abs6\"><jats:title>Results.<\/jats:title><jats:p>One hundred eighty patients from LTCFs were matched to 180 community patients. KPC-producing <jats:italic>Enterobacteriaceae<\/jats:italic> colonization was detected in 15 (8.3%) of the LTCF patients and 0 (0%) of the community patients (<jats:italic>P<\/jats:italic>&lt;.001). Prevalence of carriage differed by LTCF subtype: 2 of 135 (1.5%) patients from skilled nursing facilities without ventilator care (SNFs) were colonized upon admission, compared to 9 of 33 (27.3%) patients from skilled nursing facilities with ventilator care (VSNFs) and 4 of 12 (33.3%) patients from long-term acute care hospitals (LTACHs; <jats:italic>P<\/jats:italic>&lt;.001). In a multivariable logistic regression model adjusted for a propensity score that predicted LTCF subtype, patients admitted from VSNFs or LTACHs had 7.0-fold greater odds of colonization (ie, odds ratio; 95% confidence interval, 1.3\u201342; <jats:italic>P<\/jats:italic> = .022) with KPC-producing <jats:italic>Enterobacteriaceae<\/jats:italic> than patients from an SNF.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700050505_abs7\"><jats:title>Conclusions.<\/jats:title><jats:p>Patients admitted to acute care hospitals from high-acuity LTCFs (ie, VSNFs and LTACHs) were more likely to be colonized with KPC-producing <jats:italic>Enterobacteriaceae<\/jats:italic> than were patients admitted from the community. Identification of healthcare facilities with a high prevalence of colonized patients presents an opportunity for focused interventions that may aid regional control efforts.<\/jats:p><\/jats:sec>","DOI":"10.1086\/668435","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T18:29:33Z","timestamp":1351189773000},"page":"1193-1199","source":"Crossref","is-referenced-by-count":87,"title":["Transfer from High-Acuity Long-Term Care Facilities Is Associated with Carriage of <i>Klebsiella pneumoniae<\/i> Carbapenemase\u2013Producing <i>Enterobacteriaceae<\/i>: A Multihospital Study"],"prefix":"10.1017","volume":"33","author":[{"given":"Kavitha","family":"Prabaker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"McNally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartikeya","family":"Cherabuddi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Lolans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruba","family":"Odeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Chundi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Centers for Disease Control and Prevention (CDC) Prevention Epicenters Program","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,2]]},"reference":[{"key":"S0195941700050505_ref009","first-page":"1418","article-title":"Centers for Disease Control and Prevention (CDC). 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