{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:04:46Z","timestamp":1782781486518,"version":"3.54.5"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":731,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec id=\"S0195941700031933_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To determine relative rates of blood culture contamination for 3 skin antisepsis interventions\u201410% povidone iodine aqueous solution (PI), 2% iodine tincture (IT), and 2% Chlorhexidine gluconate in 70% isopropyl alcohol (CHG)\u2014when used by dedicated phlebotomy teams to obtain peripheral blood cultures.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031933_abs2\"><jats:title>Design.<\/jats:title><jats:p>Randomized crossover trial with hospital floor as the unit of randomization.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031933_abs3\"><jats:title>Setting.<\/jats:title><jats:p>Teaching hospital with 885 beds.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031933_abs4\"><jats:title>Patients.<\/jats:title><jats:p>All adult patients undergoing peripheral blood culture collection on 3 medical-surgical floors from May 2009 through September 2009.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031933_abs5\"><jats:title>Intervention.<\/jats:title><jats:p>Each antisepsis intervention was used for 5 months on each study floor, with random crossover after a 1-month washout period. Phlebotomy teams collected all peripheral blood cultures. Each positive blood culture was adjudicated by physicians blinded to the intervention and scored as a true positive or contaminated blood culture. The primary outcome was the rate of blood culture contamination for each antisepsis agent.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031933_abs6\"><jats:title>Results.<\/jats:title><jats:p>In total, 12,904 peripheral blood culture sets were evaluated, of which 735 (5.7%) were positive. There were 98 contaminated cultures, representing 13.3% of all positive cultures. The overall blood culture contamination rate for the study population was 0.76%. Intent-to-treat rates of contaminated blood cultures were not significantly different among the 3 antiseptics (<jats:italic>P<\/jats:italic>= .18), yielding 0.58% with PI (95% confidence interval [CI], 0.38%-0.86%), 0.76% with IT (95% CI, 0.52%-1.07%), and 0.93% with CHG (95% CI, 0.67%-1.27%).<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031933_abs7\"><jats:title>Conclusion.<\/jats:title><jats:p>Choice of antiseptic agent does not impact contamination rates when blood cultures are obtained by a phlebotomy team and should, therefore, be based on costs or preference.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700031933_abs8\"><jats:title>Trial Registration.<\/jats:title><jats:p>ClinicalTrials.gov identifier: NCT01216761.<\/jats:p><\/jats:sec>","DOI":"10.1086\/668777","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T22:33:17Z","timestamp":1353969197000},"page":"15-21","source":"Crossref","is-referenced-by-count":47,"title":["Blood Culture Contamination A Randomized Trial Evaluating the Comparative Effectiveness of 3 Skin Antiseptic Interventions"],"prefix":"10.1017","volume":"34","author":[{"given":"Laraine L.","family":"Washer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Chenoweth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A. 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