{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:50:25Z","timestamp":1790693425347,"version":"4.1.0"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T00:00:00Z","timestamp":1420156800000},"content-version":"unspecified","delay-in-days":611,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infect. Control Hosp. Epidemiol."],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:sec id=\"S0195941700032902_abs1\"><jats:title>Objective.<\/jats:title><jats:p>To quantify the association between admission to an intensive care unit (ICU) room most recently occupied by a patient positive for extended-spectrum<jats:italic>\u03b2<\/jats:italic>-lactamase (EBSL)-producing gram-negative bacteria and acquisition of infection or colonization with that pathogen.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700032902_abs2\"><jats:title>Design.<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700032902_abs3\"><jats:title>Setting and Patients.<\/jats:title><jats:p>The study included patients admitted to medical and surgical ICUs of an academic medical center between September 1, 2001, and June 30, 2009.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700032902_abs4\"><jats:title>Methods.<\/jats:title><jats:p>Perianal surveillance cultures were obtained at admission to the ICU, weekly, and at discharge from the ICU. Patients were included if they had culture results that were negative for ESBL-producing gram-negative bacteria at ICU admission and had an ICU length of stay longer than 48 hours. Pulsed-field gel electrophoresis (PFGE) was performed on ESBL-positive isolates from patients who acquired the same bacterial species (eg,<jats:italic>Klebsiella<\/jats:italic>species or<jats:italic>Escherichia coli<\/jats:italic>) as the previous room occupant.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700032902_abs5\"><jats:title>Results.<\/jats:title><jats:p>Among 9, 371 eligible admissions (7, 651 unique patients), 267 (3%) involved patients who acquired an ESBL-producing pathogen in the ICU; of these patients, 32 (12%) were hospitalized in a room in which the prior occupant had been positive for ESBL. Logistic regression results suggested that the prior occupant's ESBL status was not significantly associated with acquisition of an ESBL-producing pathogen (adjusted odds ratio, 1.39 [95% confidence interval, 0.94-2.08]) after adjusting for colonization pressure and antibiotic exposure in the ICU. PFGE results suggested that 6 (18%) of 32 patients acquired a bacterial strain that was the same as or closely related to the strain obtained from the prior occupant.<\/jats:p><\/jats:sec><jats:sec id=\"S0195941700032902_abs6\"><jats:title>Conclusions.<\/jats:title><jats:p>These data suggest that environmental contamination may not play a substantial role in the transmission of ESBL-producing pathogens among ICU patients. Intensifying environmental decontamination may be less effective than other interventions in preventing transmission of ESBL-producing pathogens.<\/jats:p><\/jats:sec>","DOI":"10.1086\/670216","type":"journal-article","created":{"date-parts":[[2013,4,9]],"date-time":"2013-04-09T14:07:17Z","timestamp":1365516437000},"page":"453-458","source":"Crossref","is-referenced-by-count":52,"title":["Risk of Acquiring Extended-Spectrum<i>\u03b2<\/i>-Lactamase\u2013Producing<i>Klebsiella<\/i>Species and<i>Escherichia coli<\/i>from Prior Room Occupants in the Intensive Care Unit"],"prefix":"10.1017","volume":"34","author":[{"given":"Adebola O.","family":"Ajao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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